Trials
Trials and primary studies
Every primary study the non-Cochrane dental caries reviews include, resolved to one record per study so a trial included by several reviews is counted once. Most are randomized trials; aetiology and diagnostic reviews also include observational and accuracy studies.
Primary studies
5,083
2,113 PMID · 1,332 DOI · 1,638 author and year
In two or more reviews
277
overlap between reviews
Trial PICO extracted
0
extraction not run yet
Per-trial results
0
extraction not run yet
ReviewStudies included by Clinical Effects of Sugar Substitutes on Cariogenic Bacteria: A Systematic Review and Meta-Analysis.. Show all studies
49 studies, most shared first
| Study | Year | Reviews | Outcome links | Trial PICO |
|---|---|---|---|---|
| The Effect of Chlorhexidine/Xylitol Chewing-Gum on Cariogenic Salivary Microflora: A Clinical Trial in Elderly Patients Simons 1997 · Simons D., Kidd E.A.M., et al. · Caries Research DOI:10.1159/000262382 | 2009 | 2 | none stated | not extracted yet |
| Long-Term Effect of Xylitol Gum Use on Mutans Streptococci in Adults Haresaku 2007 · Haresaku S., Hanioka T., et al. · Caries Research DOI:10.1159/000099318 | 2007 | 2 | 2 | not extracted yet |
| Wang 2006 matched by author and year (probable) | NR | 2 | 2 | not extracted yet |
| A Comparative Evaluation of Xylitol Chewing Gum and a Combination of IgY + Xylitol Chewable Tablet on Salivary Streptococcus mutans Count in… Jain et al. 2022 · Jain Rashi L, Tandon Sandeep, et al. · International journal of clinical pediatric dentistry PMID:35645521 | 2022 | 1 | 1 | not extracted yet |
| Impact of polyols on Oral microbiome of Estonian schoolchildren. Stsepetova et al. 2019 · Štšepetova Jelena, Truu Jaak, et al. · BMC oral health PMID:30999906 | 2019 | 1 | none stated | not extracted yet |
| Effect of a Daily Dose of Snacks Containing Maltitol or Stevia rebaudiana as Sweeteners in High Caries Risk Schoolchildren. A Double-blind RCT Study. Cocco 2019 · Cocco Fabio, Cagetti Maria Grazia, et al. · Oral health & preventive dentistry PMID:31641701 | 2019 | 1 | none stated | not extracted yet |
| Effectiveness of xylitol and polyol chewing gum on salivary streptococcus mutans in children: A randomized controlled trial Aluckal et al. 2018 · Aluckal Eby, Ankola AnilV · Indian Journal of Dental Research DOI:10.4103/ijdr.ijdr_307_16 | 2018 | 1 | 1 | not extracted yet |
| Effectiveness of xylitol and polyol chewing gum on salivary streptococcus mutans in children: A randomized controlled trial. Aluckal 2018 · Aluckal Eby, Ankola Anil V · Indian journal of dental research : official publication of Indian Society for Dental Research PMID:30127194 | 2018 | 1 | none stated | not extracted yet |
| Milk Sweetened with Xylitol: A Proof-of-Principle Caries Prevention Randomized Clinical Trial. Chi et al. 2016 · Chi Donald L, Zegarra Graciela, et al. · Journal of dentistry for children (Chicago, Ill.) PMID:28327266 | 2016 | 1 | 1 | not extracted yet |
| Effects of short-term xylitol gum chewing on the oral microbiome. Soderling 2015 · Söderling Eva, ElSalhy Mohamed, et al. · Clinical oral investigations PMID:24663814 | 2015 | 1 | none stated | not extracted yet |
| The effect of two types chewing gum containing casein phosphopeptide-amorphous calcium phosphate and xylitol on salivary Streptococcus mutans. Emamieh et al. 2015 · Emamieh Shila, Khaterizadeh Yosra, et al. · Journal of conservative dentistry : JCD PMID:26069402 | 2015 | 1 | none stated | not extracted yet |
| Effects of short-term xylitol gum chewing on the oral microbiome Soderling et al. 2015 · Söderling Eva, ElSalhy Mohamed, et al. · Clinical Oral Investigations DOI:10.1007/s00784-014-1229-y | 2014 | 1 | 1 | not extracted yet |
| Early prevention of childhood caries with maternal xylitol consumption. Alamoudi et al. 2014 · Alamoudi Najlaa M, Hanno Azza G, et al. · Saudi medical journal PMID:24888659 | 2014 | 1 | none stated | not extracted yet |
| <i>Bifidobacterium</i><i>animalis</i> subsp. <i>lactis</i> BB-12 Administration in Early Childhood: A Randomized… Taipale et al. 2012 · Taipale T., Pienihäkkinen K., et al. · Caries Research DOI:10.1159/000335567 | 2012 | 1 | none stated | not extracted yet |
| Impact of Maternal Xylitol Consumption on Mutans Streptococci, Plaque and Caries Levels in Children Alamoudi et al. 2012 (J Clin Pediatr Dent) · Alamoudi N M, Hanno A G, et al. · Journal of Clinical Pediatric Dentistry DOI:10.17796/jcpd.37.2.261782tq73k4414x | 2012 | 1 | none stated | not extracted yet |
| Bifidobacterium animalis subsp. lactis BB-12 administration in early childhood: a randomized clinical trial of effects on oral colonization by… Taipale 2012 · Taipale T, Pienihäkkinen K, et al. · Caries research PMID:22327347 | 2012 | 1 | none stated | not extracted yet |
| Effects of xylitol on salivary mutans streptococcus, plaque level, and caries activity in a group of Saudi mother-child pairs. An 18-month clinical… Alamoudi et al. 2012 (Saudi Med J) · Alamoudi Najlaa M, Hanno Azza G, et al. · Saudi medical journal PMID:22327761 | 2012 | 1 | none stated | not extracted yet |
| Impact of maternal xylitol consumption on mutans streptococci, plaque and caries levels in children. Alamoudi 2012 · Alamoudi Najlaa M, Hanno Azza G, et al. · The Journal of clinical pediatric dentistry PMID:23534323 | 2012 | 1 | none stated | not extracted yet |
| Effect of xylitol gum on the level of oral mutans streptococci of preschoolers: block-randomised trial. Seki et al. 2011 · Seki Mitsuko, Karakama Fumiyuki, et al. · International dental journal PMID:21995376 | 2011 | 1 | none stated | not extracted yet |
| Xylitol gum and maternal transmission of mutans streptococci. Nakai 2010 · Nakai Y, Shinga-Ishihara C, et al. · Journal of dental research PMID:19948944 | 2010 | 1 | none stated | not extracted yet |
| Xylitol Gum and Maternal Transmission of Mutans Streptococci Nakai et al. 2010 · Nakai Y., Shinga-Ishihara C., et al. · Journal of Dental Research DOI:10.1177/0022034509352958 | 2009 | 1 | none stated | not extracted yet |
| Morphological changes in Streptococcus mutans after chewing gum containing xylitol for twelve months. Lee 2009 · Lee Young-Eun, Choi Youn-Hee, et al. · Current microbiology PMID:19085034 | 2009 | 1 | none stated | not extracted yet |
| Xylitol: effects on the acquisition of cariogenic species in infants. Fontana et al. 2009 · Fontana Margherita, Catt Diana, et al. · Pediatric dentistry PMID:19552232 | 2009 | 1 | none stated | not extracted yet |
| Morphological Changes in Streptococcus mutans After Chewing Gum Containing Xylitol for Twelve Months Lee et al. 2009 · Lee Young-Eun, Choi Youn-Hee, et al. · Current Microbiology DOI:10.1007/s00284-008-9332-4 | 2008 | 1 | 1 | not extracted yet |
| Thirty-nine-month xylitol chewing-gum programme in initially 8-year-old school children: a feasibility study focusing on mutans streptococci and… Makinen et al. 2008 · Mäkinen Kauko K., Alanen Pentti, et al. · International Dental Journal DOI:10.1111/j.1875-595x.2008.tb00175.x | 2008 | 1 | none stated | not extracted yet |
| Thirty-nine-month xylitol chewing-gum programme in initially 8-year-old school children: a feasibility study focusing on mutans streptococci and… Makinen 2008 · Mäkinen Kauko K, Alanen Pentti, et al. · International dental journal PMID:18350853 | 2008 | 1 | none stated | not extracted yet |
| Xylitol gummy bear snacks: a school-based randomized clinical trial. Ly et al. 2008 · Ly Kiet A, Riedy Christine A, et al. · BMC oral health PMID:18657266 | 2008 | 1 | none stated | not extracted yet |
| Effect of chewing gums containing xylitol or probiotic bacteria on salivary mutans streptococci and lactobacilli Caglar et al. 2007 · Çaglar E., Kavaloglu S. C., et al. · Clinical Oral Investigations DOI:10.1007/s00784-007-0129-9 | 2007 | 1 | none stated | not extracted yet |
| Dental plaque formation and salivary mutans streptococci in schoolchildren after use of xylitol-containing chewing gum. Holgerson 2007 · Holgerson Pernilla Lif, Sjöström Inger, et al. · International journal of paediatric dentistry PMID:17263856 | 2007 | 1 | none stated | not extracted yet |
| Long-term effect of xylitol gum use on mutans streptococci in adults. Haresaku 2007 · Haresaku S, Hanioka T, et al. · Caries research PMID:17426399 | 2007 | 1 | none stated | not extracted yet |
| Effect of chewing gums containing xylitol or probiotic bacteria on salivary mutans streptococci and lactobacilli. Caglar 2007 · Caglar E, Kavaloglu S C, et al. · Clinical oral investigations PMID:17574481 | 2007 | 1 | none stated | not extracted yet |
| Dental plaque formation and salivary mutans streptococci in schoolchildren after use of xylitol‐containing chewing gum Holgerson et al. 2006 · HOLGERSON PERNILLA LIF, SJÖSTRÖM INGER, et al. · International Journal of Paediatric Dentistry DOI:10.1111/j.1365-263x.2006.00808.x | 2006 | 1 | 1 | not extracted yet |
| Mutans streptococci dose response to xylitol chewing gum. Milgrom et al. 2006 · Milgrom P, Ly K A, et al. · Journal of dental research PMID:16434738 | 2006 | 1 | 1 | not extracted yet |
| Linear response of mutans streptococci to increasing frequency of xylitol chewing gum use: a randomized controlled trial [ISRCTN43479664]. Ly et al. 2006 · Ly Kiet A, Milgrom Peter, et al. · BMC oral health PMID:16556326 | 2006 | 1 | none stated | not extracted yet |
| Six-month polyol chewing-gum programme in kindergarten-age children: a feasibility study focusing on mutans streptococci and dental plaque Makinen et al. 2005 · Mäkinen Kauko K., Isotupa Kauko P., et al. · International Dental Journal DOI:10.1111/j.1875-595x.2005.tb00038.x | 2005 | 1 | none stated | not extracted yet |
| Six-month polyol chewing-gum programme in kindergarten-age children: a feasibility study focusing on mutans streptococci and dental plaque. Mäkinen 2005 · Mäkinen Kauko K, Isotupa Kauko P, et al. · International dental journal PMID:15880962 | 2005 | 1 | none stated | not extracted yet |
| Salivary mutans streptococci and dental caries in three-year-old children after maternal exposure to chewing gums containing combinations of… Thorild et al. 2004 · Thorild Ingrid, Lindau Britt, et al. · Acta Odontologica Scandinavica DOI:10.1080/00016350410001676 | 2004 | 1 | none stated | not extracted yet |
| Salivary mutans streptococci and dental caries in three-year-old children after maternal exposure to chewing gums containing combinations of… Thorild 2004 · Thorild Ingrid, Lindau Britt, et al. · Acta odontologica Scandinavica PMID:15841810 | 2004 | 1 | none stated | not extracted yet |
| The effect of xylitol chewing gum on mutans streptococci in saliva and dental plaque. Thaweboon et al. 2004 · Thaweboon Sroisiri, Thaweboon Boonyanit, et al. · The Southeast Asian journal of tropical medicine and public health PMID:15916109 | 2004 | 1 | 1 | not extracted yet |
| Effect of xylitol chewing gum on salivary Streptococcus mutans in preschool children. Autio et al. 2002 · Autio Jaana T · ASDC journal of dentistry for children PMID:12119821 | 2002 | 1 | none stated | not extracted yet |
| Influence of Maternal Xylitol Consumption on Acquisition of Mutans Streptococci by Infants Soderling et al. 2000 · Soderling E., Isokangas P., et al. · Journal of Dental Research DOI:10.1177/00220345000790031601 | 2000 | 1 | none stated | not extracted yet |
| Influence of maternal xylitol consumption on acquisition of mutans streptococci by infants. Söderling 2000 · Söderling E, Isokangas P, et al. · Journal of dental research PMID:10765964 | 2000 | 1 | none stated | not extracted yet |
| The effect of chlorhexidine/xylitol chewing-gum on cariogenic salivary microflora: a clinical trial in elderly patients. Simons 1997 · Simons D, Kidd E A, et al. · Caries research PMID:9118190 | 1997 | 1 | none stated | not extracted yet |
| Effect of polyol gums on dental plaque in orthodontic patients Isotupa et al. 1995 · Isotupa K.P., Gunn S., et al. · American Journal of Orthodontics and Dentofacial Orthopedics DOI:10.1016/s0889-5406(95)70117-6 | 1995 | 1 | 1 | not extracted yet |
| Effect of polyol gums on dental plaque in orthodontic patients. Isotupa 1995 · Isotupa K P, Gunn S, et al. · American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics PMID:7733059 | 1995 | 1 | none stated | not extracted yet |
| The effect of chewing xylitol gum on the plaque and saliva levels of Streptococcus mutans Loesche et al. 1984 · Loesche Walter J., Grossman Natalie S., et al. · The Journal of the American Dental Association DOI:10.14219/jada.archive.1984.0390 | 1984 | 1 | none stated | not extracted yet |
| The effect of chewing xylitol gum on the plaque and saliva levels of Streptococcus mutans. Loesche 1984 · Loesche W J, Grossman N S, et al. · Journal of the American Dental Association (1939) PMID:6427315 | 1984 | 1 | none stated | not extracted yet |
| Cocco et al. 2019 DOI:10.3290/j.ohpd.a43329 | NR | 1 | 1 | not extracted yet |
| Wang et al. 2014 matched by author and year (probable) | NR | 1 | 1 | not extracted yet |