Studies
Primary studies
26,293 studies included by 1,022 non-Cochrane dental reviews extracted from full text, one record per study, so a study included by several reviews is counted once. Most are randomized trials; etiology and diagnostic reviews also include observational and accuracy studies. Cochrane reviews and reviews with only their headline outcomes do not list their included studies here yet.
ReviewStudies included by Advanced, pharmacological and complementary interventions for chronic or recurrent orofacial pain conditions: a systematic evidence map…. Show all studies
| Study | Year | Reviews | Review outcomes linked | Trial data |
|---|---|---|---|---|
| Long-term efficacy of photobiomodulation in burning mouth syndrome: A secondary analysis of a randomized controlled trial Lu 2026 · Lu Chenghui, Zhang Xinyu, et al. · Journal of Dentistry DOI:10.1016/j.jdent.2025.106275 | 2026 | 1 | none stated | not extracted yet |
| Clinical Efficacy of Acupuncture Combined With Manual Therapy in the Treatment of Temporomandibular Disorders Myalgia and Observation of the Changes… Yu 2025 · Yu Jing, Zhang Yuxin, et al. · Journal of oral rehabilitation PMID:41116718 | 2026 | 1 | none stated | not extracted yet |
| Long-term efficacy of photobiomodulation in burning mouth syndrome: A secondary analysis of a randomized controlled trial. Lu 2026 · Lu Chenghui, Zhang Xinyu, et al. · Journal of dentistry PMID:41338367 | 2026 | 1 | none stated | not extracted yet |
| Piano level laser therapy versus epidermal growth factor injection for painful myogenic temporomandibular disorder (a randomized clinical trial) Qataya 2025 · Qataya Passant Osama, Zaki Azza Mohamed, et al. · Clinical Oral Investigations DOI:10.1007/s00784-025-06189-5 | 2025 | 1 | none stated | not extracted yet |
| Adjunctive 810 nm photobiomodulation with pharmacotherapy for trigeminal neuralgia: A randomized controlled trial in a tertiary care centre Shukla 2025 · Shukla Saumya, Srivastava Adit, et al. · Journal of Photochemistry and Photobiology B: Biology DOI:10.1016/j.jphotobiol.2025.113249 | 2025 | 1 | none stated | not extracted yet |
| Clinical Efficacy of Acupuncture Combined With Manual Therapy in the Treatment of Temporomandibular Disorders Myalgia and Observation of the Changes… Yu 2025 · Yu Jing, Zhang Yuxin, et al. · Journal of Oral Rehabilitation DOI:10.1111/joor.70090 | 2025 | 1 | 2 | not extracted yet |
| Effect of Nd‐ <scp>YAG</scp> Laser Versus Epidermal Growth Factor Injection on Salivary Pain Mediators in Myogenic Temporomandibular Disorders (A… Qataya 2025 · Qataya Passant Osama, Zaki Azza Mohamed, et al. · Journal of Oral Pathology & Medicine DOI:10.1111/jop.70053 | 2025 | 1 | 1 | not extracted yet |
| Efficacy and safety of photobiomodulation combined with oral cryotherapy on oral mucosa pain in patients with burning mouth syndrome: a… Lu 2025 · Lu Chenghui, Zhou Xuan, et al. · BMC Medicine DOI:10.1186/s12916-025-04015-z | 2025 | 1 | none stated | not extracted yet |
| Evaluating the Efficacy of a Digital Therapeutic Intervention for Temporomandibular Disorders: Multicenter, Randomized, Sham-Controlled Trial Park 2025 · Park Sang-Yoon, On Sung-Woon, et al. · Journal of Medical Internet Research DOI:10.2196/83545 | 2025 | 1 | none stated | not extracted yet |
| Effectiveness of continuous and pulse mode of ultrasound therapy in temporomandibular disorders associated myalgia—a randomized controlled study Saini 2025 · Journal of Oral & Facial Pain and Headache DOI:10.22514/jofph.2025.007 | 2025 | 1 | none stated | not extracted yet |
| Safety and efficacy of percutaneous radiofrequency thermocoagulation with varying puncture trajectories for recurrent maxillary trigeminal… Du 2025 · Du Yuanyuan, Liu Xiaohui, et al. · Frontiers in Neurology DOI:10.3389/fneur.2025.1577399 | 2025 | 1 | none stated | not extracted yet |
| Patient satisfaction and pain relief following radiofrequency rhizotomy for trigeminal neuralgia: a prospective cohort study Faizo 2025 · Faizo Eyad, Kurdi Maher, et al. · Frontiers in Pain Research DOI:10.3389/fpain.2025.1639140 | 2025 | 1 | none stated | not extracted yet |
| Single intra-articular administration of injectable platelet-rich fibrin (I-PRF) in alleviating temporomandibular joint pain: A pilot clinical trial. Sielski 2025 · Sielski Marcin, Chęcińska Kamila, et al. · Dental and medical problems PMID:40043084 | 2025 | 1 | none stated | not extracted yet |
| Effectiveness of continuous and pulse mode of ultrasound therapy in temporomandibular disorders associated myalgia-a randomized controlled study. Saini 2025 · Saini Bhawna, Gupta Ambika, et al. · Journal of oral & facial pain and headache PMID:40129425 | 2025 | 1 | none stated | not extracted yet |
| Efficacy and safety of photobiomodulation combined with oral cryotherapy on oral mucosa pain in patients with burning mouth syndrome: a… Lu 2025 · Lu Chenghui, Zhou Xuan, et al. · BMC medicine PMID:40189502 | 2025 | 1 | none stated | not extracted yet |
| Comparison of the Effect of 810 nm Diode Laser and Transcranial Direct Current Stimulation on Relieving Symptoms of Patients With Temporomandibular… Yassaei 2025 · Yassaei Soghra, Mohsenzade Parisa, et al. · Journal of lasers in medical sciences PMID:40330508 | 2025 | 1 | none stated | not extracted yet |
| Safety and efficacy of percutaneous radiofrequency thermocoagulation with varying puncture trajectories for recurrent maxillary trigeminal… Du 2025 · Du Yuanyuan, Liu Xiaohui, et al. · Frontiers in neurology PMID:40697569 | 2025 | 1 | none stated | not extracted yet |
| Effect of Nd-YAG Laser Versus Epidermal Growth Factor Injection on Salivary Pain Mediators in Myogenic Temporomandibular Disorders (A Randomized… Qataya 2025 · Qataya Passant Osama, Zaki Azza Mohamed, et al. · Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology PMID:40891771 | 2025 | 1 | none stated | not extracted yet |
| Adjunctive 810 nm photobiomodulation with pharmacotherapy for trigeminal neuralgia: A randomized controlled trial in a tertiary care centre. Shukla 2025 · Shukla Saumya, Srivastava Adit, et al. · Journal of photochemistry and photobiology. B, Biology PMID:40907240 | 2025 | 1 | none stated | not extracted yet |
| Patient satisfaction and pain relief following radiofrequency rhizotomy for trigeminal neuralgia: a prospective cohort study. Faizo 2025 · Faizo Eyad, Kurdi Maher, et al. · Frontiers in pain research (Lausanne, Switzerland) PMID:40958819 | 2025 | 1 | none stated | not extracted yet |
| Evaluating the Efficacy of a Digital Therapeutic Intervention for Temporomandibular Disorders: Multicenter, Randomized, Sham-Controlled Trial. Park 2025 · Park Sang-Yoon, On Sung-Woon, et al. · Journal of medical Internet research PMID:41135079 | 2025 | 1 | none stated | not extracted yet |
| Patient-Reported Outcome Measures After Botulinum Toxin for Temporomandibular-Related Myalgia: A Prospective Study. van Soest 2025 · van Soest Martijn, Remijn Lianne, et al. · Journal of clinical medicine PMID:41226892 | 2025 | 1 | none stated | not extracted yet |
| Ultrasound‐Guided Vs Non‐Guided Prolotherapy for Internal Derangement of Temporomandibular Joint. A Randomized Clinical Trial Kheder 2024 · Alhaj Kheder Mohammad Badr, Kandil Nour Mohamed, et al. · Journal of Ultrasound in Medicine DOI:10.1002/jum.16462 | 2024 | 1 | 1 | not extracted yet |
| Electroacupuncture and carbamazepine for patients with trigeminal neuralgia: a randomized, controlled, 2 × 2 factorial trial Li 2024 · Li Rongrong, Sun Jing, et al. · Journal of Neurology DOI:10.1007/s00415-024-12433-x | 2024 | 1 | none stated | not extracted yet |
| Manual therapy and dry needling improve mobility, pain and reduce fear of COVID-19 in temporomandibular disorder patients: Randomized controlled trial Ferreira 2024 · Ferreira Caio César Quintiliano, Lima Karen Rodrigues, et al. · Journal of Bodywork and Movement Therapies DOI:10.1016/j.jbmt.2024.05.015 | 2024 | 1 | 2 | not extracted yet |
| Low-intensity pulsed ultrasound in the treatment of masticatory myositis and temporomandibular joint synovitis: A clinical trial Zhang 2024 · Zhang Xiaoqing, Gao Wentong, et al. · Journal of Stomatology, Oral and Maxillofacial Surgery DOI:10.1016/j.jormas.2023.101632 | 2024 | 1 | none stated | not extracted yet |
| Exploring HD-tDCS Effect on μ-opioid Receptor and Pain Sensitivity in Temporomandibular Disorder: A Pilot Randomized Clinical Trial Study Kim 2024 · Kim Dajung J., Nascimento Thiago D., et al. · The Journal of Pain DOI:10.1016/j.jpain.2023.11.001 | 2024 | 1 | none stated | not extracted yet |
| Efficacy of 660 nm Photobiomodulation in Burning Mouth Syndrome Management: A Single-Blind Quasi-Experimental Controlled Clinical Trial Marotta 2024 · Marotta Bruno Munhoz, Sugaya Norberto Nobuo, et al. · Photobiomodulation, Photomedicine, and Laser Surgery DOI:10.1089/photob.2023.0158 | 2024 | 1 | none stated | not extracted yet |
| Effect of acupuncture for temporomandibular disorders: a randomized clinical trial Liu 2024 · Liu Lu, Chen Qiuyi, et al. · QJM: An International Journal of Medicine DOI:10.1093/qjmed/hcae094 | 2024 | 1 | none stated | not extracted yet |
| One session of repetitive transcranial magnetic stimulation induces mild and transient analgesic effects among female individuals with painful… Herrero Babiloni 2024 · Herrero Babiloni Alberto, Provost Catherine, et al. · Journal of Oral Rehabilitation DOI:10.1111/joor.13655 | 2024 | 1 | none stated | not extracted yet |
| Clinical benefit of botulinum toxin for treatment of persistent <scp>TMD</scp>‐related myofascial pain: A randomized, placebo‐controlled, cross‐over… Sitnikova 2024 · Sitnikova V., Kämppi A., et al. · Pain Practice DOI:10.1111/papr.13396 | 2024 | 1 | none stated | not extracted yet |
| Efficacy and safety profile of Onabotulinum toxin-A injection at sphenopalatine ganglion in trigeminal neuralgia: a prospective observational study Thepsoparn 2024 · Thepsoparn Marvin, Anukoolwittaya Prakit, et al. · The Journal of Headache and Pain DOI:10.1186/s10194-024-01926-9 | 2024 | 1 | none stated | not extracted yet |
| Effects of adding electro-massage to manual therapy for the treatment of individuals with myofascial temporomandibular pain: a randomized controlled… Espejo-Antúnez 2024 · ESPEJO-ANTÚNEZ Luis, CARDERO-DURÁN María de los Ángeles, et al. · Journal of Applied Oral Science DOI:10.1590/1678-7757-2024-0109 | 2024 | 1 | none stated | not extracted yet |
| Efficacy of cranial electrotherapy stimulation in patients with burning mouth syndrome: a randomized, controlled, double-blind pilot study Palmer 2024 · Palmer Annalena, Hamann Till, et al. · Frontiers in Neurology DOI:10.3389/fneur.2024.1343093 | 2024 | 1 | none stated | not extracted yet |
| Burning Mouth Syndrome Treated with Low-Level Laser and Clonazepam: A Randomized, Single-Blind Clinical Trial Garcia Martinez 2024 · Garcia Martinez Ana, Lopez-Jornet Pia, et al. · Biomedicines DOI:10.3390/biomedicines12051048 | 2024 | 1 | 2 | not extracted yet |
| Long-Term Benefits of Photobiomodulation Therapy on Health-Related Quality of Life in Burning Mouth Syndrome Patients: A Prospective Study de Abreu 2024 · de Abreu João Mendes, Nunes Tiago, et al. · Journal of Clinical Medicine DOI:10.3390/jcm13144272 | 2024 | 1 | none stated | not extracted yet |
| Clinical Efficacy of Two Different Low-Level Laser Therapies for the Treatment of Trigeminal Neuralgia: A Randomized, Placebo-Controlled Trial Karagözoğlu 2024 · Karagözoğlu İrem, Demirkol Nermin, et al. · Journal of Clinical Medicine DOI:10.3390/jcm13226890 | 2024 | 1 | none stated | not extracted yet |
| Dry needling and upper cervical spinal manipulation in patients with temporomandibular disorder: A multi-center randomized clinical trial. Dunning 2024 · Dunning James, Butts Raymond, et al. · Cranio : the journal of craniomandibular practice PMID:35412448 | 2024 | 1 | none stated | not extracted yet |
| Low-intensity pulsed ultrasound in the treatment of masticatory myositis and temporomandibular joint synovitis: A clinical trial. Zhang 2024 · Zhang Xiaoqing, Gao Wentong, et al. · Journal of stomatology, oral and maxillofacial surgery PMID:37703917 | 2024 | 1 | none stated | not extracted yet |
| Exploring HD-tDCS Effect on μ-opioid Receptor and Pain Sensitivity in Temporomandibular Disorder: A Pilot Randomized Clinical Trial Study. Kim 2024 · Kim Dajung J, Nascimento Thiago D, et al. · The journal of pain PMID:37956741 | 2024 | 1 | none stated | not extracted yet |
| Comparison of low-level laser therapy and standard treatment for temporomandibular disorders: An assessment of therapeutic and placebo effects. Chamani 2024 · Chamani Goli, Zarei Mohammad Reza, et al. · Journal of oral rehabilitation PMID:38012102 | 2024 | 1 | none stated | not extracted yet |
| One session of repetitive transcranial magnetic stimulation induces mild and transient analgesic effects among female individuals with painful… Herrero Babiloni 2024 · Herrero Babiloni Alberto, Provost Catherine, et al. · Journal of oral rehabilitation PMID:38225806 | 2024 | 1 | none stated | not extracted yet |
| Efficacy of 660 nm Photobiomodulation in Burning Mouth Syndrome Management: A Single-Blind Quasi-Experimental Controlled Clinical Trial. Marotta 2024 · Marotta Bruno Munhoz, Sugaya Norberto Nobuo, et al. · Photobiomodulation, photomedicine, and laser surgery PMID:38407832 | 2024 | 1 | none stated | not extracted yet |
| Efficacy of cranial electrotherapy stimulation in patients with burning mouth syndrome: a randomized, controlled, double-blind pilot study. Palmer 2024 · Palmer Annalena, Hamann Till, et al. · Frontiers in neurology PMID:38419716 | 2024 | 1 | none stated | not extracted yet |
| Burning Mouth Syndrome Treated with Low-Level Laser and Clonazepam: A Randomized, Single-Blind Clinical Trial. Garcia Martinez 2024 · Garcia Martinez Ana, Lopez-Jornet Pia, et al. · Biomedicines PMID:38791010 | 2024 | 1 | none stated | not extracted yet |
| A Comparison Between the Efficacy of Trigeminal Ganglion Radiofrequency Thermocoagulation and Ultrasound-Guided Maxillary-Mandibular Nerve Pulsed… Yildiz 2024 · Yildiz Gokhan, Akkaya Omer Taylan · Cureus PMID:38962582 | 2024 | 1 | none stated | not extracted yet |
| Clinical benefit of botulinum toxin for treatment of persistent TMD-related myofascial pain: A randomized, placebo-controlled, cross-over trial. Sitnikova 2024 · Sitnikova V, Kämppi A, et al. · Pain practice : the official journal of World Institute of Pain PMID:38963228 | 2024 | 1 | none stated | not extracted yet |
| Long-Term Benefits of Photobiomodulation Therapy on Health-Related Quality of Life in Burning Mouth Syndrome Patients: A Prospective Study. de Abreu 2024 · de Abreu João Mendes, Nunes Tiago, et al. · Journal of clinical medicine PMID:39064312 | 2024 | 1 | none stated | not extracted yet |
| Efficacy and safety profile of Onabotulinum toxin-A injection at sphenopalatine ganglion in trigeminal neuralgia: a prospective observational study. Thepsoparn 2024 · Thepsoparn Marvin, Anukoolwittaya Prakit, et al. · The journal of headache and pain PMID:39623300 | 2024 | 1 | none stated | not extracted yet |
| Effectiveness of double-puncture temporomandibular joint arthrocentesis with viscosupplementation in different categories of severity – a… Ângelo 2023 · Ângelo David Faustino, Sanz David, et al. · Journal of Cranio-Maxillofacial Surgery DOI:10.1016/j.jcms.2023.09.010 | 2023 | 1 | none stated | not extracted yet |