Non-Cochrane · aetiology · PM42506083
Salivary Oxidative Stress Biomarkers in Temporomandibular Disorders: A Systematic Review and Meta-Analysis.
Chauca Bajaña Luis, Cruz Moreno Tatiana, Quiguango Farias Diego, et al. · Journal of personalized medicine · 2026 · PubMed · doi:10.3390/jpm16070357
Findings
3 findings
| Population | ||||
|---|---|---|---|---|
| Patients with temporomandibular disorders (TMD) | TMD (exposure: TMD-associated oxidative stress) | Healthy controls without TMD | Salivary total antioxidant capacity (TAC) Cross-sectional · Unstimulated saliva, morning collection | SMD -0.22 [-0.58, 0.14] GRADE not reported 2 studies · 116 participants |
| Patients with temporomandibular disorders (TMD) | TMD (exposure: TMD-associated oxidative stress) | Healthy controls without TMD | Salivary malondialdehyde (MDA) Cross-sectional · Unstimulated saliva, morning collection | SMD 0.92 [0.37, 1.48] GRADE not reported 1 study · 60 participants |
| Female patients with temporomandibular disorders (TMD) | Occlusal splint therapy | Baseline (before therapy) | Salivary afternoon malondialdehyde (MDA) 1 month and 3 months (pooled) · Unstimulated saliva | MD -0.45 [-0.69, -0.20] GRADE not reported 1 study · 12 participants |
Included primary studies 5
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Klepzig 2024 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| Klepzig 2024 Pain and salivary biomarkers of stress in temperomandibular disorders were affected by maxillary splints. PMID:38475974 | 2024 | this review only | not stated | not extracted yet |
| Lawaf 2015 Comparison of Serum and Salivary Antioxidants in Patients with Temporomandibular Joint Disorders and Healthy Subjects. PMID:26622281 | 2015 | this review only | Salivary total antioxidant capacity (TAC) | not extracted yet |
| Omidpanah 2020 Total Antioxidant Capacity, Catalase Activity and Salivary Oxidative Parameters in Patients with Temporomandibular Disorders. PMID:33615292 | 2020 | this review only | Salivary malondialdehyde (MDA); Salivary total antioxidant capacity (TAC) | not extracted yet |
| Vrbanovic 2019 Changes in salivary oxidative status, salivary cortisol, and clinical symptoms in female patients with temporomandibular disorders during… PMID:31170954 | 2019 | this review only | Salivary afternoon malondialdehyde (MDA) | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
| Review | Shared studies | Jaccard |
|---|---|---|
| Bias, Study Quality, and Confounding in Temporomandibular Disorder Research Compared to General Orthodontic Studies: A Systematic Review… (2025) | 1 | 0.00 |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients diagnosed with temporomandibular disorders (TMD) | Patients with TMD (n=4 studies; 20 to 180 participants per study) |
| Intervention | Presence of TMD-associated oxidative stress (exposure) | Presence of TMD; occlusal splint therapy (before-after comparison) |
| Comparison | Healthy individuals without TMD | Healthy controls (n=3 studies); baseline before splint therapy |
| Outcomes | Quantitative salivary oxidative stress biomarker levels (MDA, TAC, catalase) | Salivary MDA (1 study), TAC (2 studies), catalase, SOD, cortisol, alpha-amylase (narrative) |
| Study designs | Observational studies (cross-sectional, case-control, cohort) or clinical trials | Case-control, cross-sectional, longitudinal prospective and randomized delayed-start trial designs (n=4) |
| Timing | Not specified | Splint therapy follow-up at 1 and 3 months |