Non-Cochrane · aetiology · PM42471777
Inflammation, Hypoxia, and Periodontal Breakdown: The Association Between Obstructive Sleep Apnea and Periodontitis; Results From a Systematic Review With Meta-Analysis.
Esperouz Fariba, Lorusso Mauro, Giannini Giuseppina Raffaella, et al. · Clinical and experimental dental research · 2026 · PubMed · doi:10.1002/cre2.70401
Findings
Population Human adults assessed for both OSA and periodontal status
2 findings
| Obstructive sleep apnea (presence or risk, by PSG, home test or validated questionnaire) | Participants without OSA or with subclinical apnea | Periodontitis (occurrence or prevalence) | OR 2.22 [1.78, 2.77] GRADE not reported 18 studies |
| Obstructive sleep apnea (presence or risk, by PSG, home test or validated questionnaire) | Participants without OSA or with subclinical apnea | Periodontal disease severity (Spearman correlation with OSA) | Correlation coefficient (r) 0.39 [0.17, 0.58] GRADE not reported 5 studies |
Included primary studies 23
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Ahmad 2013 Obstructive sleep apnea in association with periodontitis: a case-control study. PMID:23986412 | 2013 | this review only | Periodontitis (occurrence or prevalence) | not extracted yet |
| Al-Habashneh 2016 DOI:10.3290/j.ohpd.a35002 | NR | this review only | Periodontitis (occurrence or prevalence) | not extracted yet |
| Ashraf 2022 Oral findings as predictors of obstructive sleep apnea- A case-control study. PMID:36505666 | 2022 | this review only | Periodontitis (occurrence or prevalence) | not extracted yet |
| Chen 2021 Analysis of Salivary Microbiome and Its Association With Periodontitis in Patients With Obstructive Sleep Apnea. PMID:34950605 | 2021 | this review only | Periodontitis (occurrence or prevalence) | not extracted yet |
| Chen 2023 Association between obstructive sleep apnea and periodontitis in Chinese male adults: A cross-sectional study DOI:10.1016/j.prosdent.2021.11.001 | 2023 | this review only | Periodontitis (occurrence or prevalence) | not extracted yet |
| Florian-Tirado 2024 Periodontitis associated with risk of obstructive sleep apnea in Peruvian adult patients: A cross-sectional study. PMID:38794941 | 2024 | this review only | Periodontal disease severity (Spearman correlation with OSA) | not extracted yet |
| Gamsiz-Isik 2017 Does Obstructive Sleep Apnea Increase the Risk for Periodontal Disease? A Case‐Control Study DOI:10.1902/jop.2016.160365 | 2017 | this review only | Periodontitis (occurrence or prevalence) | not extracted yet |
| Kale 2018 Assessment of oral findings of dental patients who screen high and no risk for obstructive sleep apnea (OSA) reporting to a dental college… PMID:30083299 | 2018 | this review only | Periodontitis (occurrence or prevalence) | not extracted yet |
| Keller 2013 Association between obstructive sleep apnoea and chronic periodontitis: a population‐based study DOI:10.1111/jcpe.12036 | 2012 | this review only | Periodontitis (occurrence or prevalence) | not extracted yet |
| Latorre 2018 Association between obstructive sleep apnea and comorbidities with periodontal disease in adults. PMID:29962700 | 2018 | this review only | Periodontitis (occurrence or prevalence) | not extracted yet |
| Loke 2015 Investigating the Association Between Obstructive Sleep Apnea and Periodontitis DOI:10.1902/jop.2014.140229 | 2015 | this review only | Periodontitis (occurrence or prevalence) | not extracted yet |
| Mukherjee 2021 Obstructive Sleep Apnea and Periodontitis DOI:10.4103/ijdr.ijdr_534_19 | 2021 | this review only | Periodontal disease severity (Spearman correlation with OSA) | not extracted yet |
| Nizam 2016 Is there an association between obstructive sleep apnea syndrome and periodontal inflammation? DOI:10.1007/s00784-015-1544-y | 2015 | this review only | Periodontal disease severity (Spearman correlation with OSA) | not extracted yet |
| Pico-Orozco 2021 Influence of body mass index and obesity upon the association between periodontitis and sleep apnea-hypopnea syndrome DOI:10.1007/s00784-020-03722-6 | 2021 | this review only | Periodontitis (occurrence or prevalence) | not extracted yet |
| Sales-Peres 2016 Periodontal Status in Morbidly Obese Patients With and Without Obstructive Sleep Apnea Syndrome Risk: A Cross‐Sectional Study DOI:10.1902/jop.2016.150587 | 2016 | this review only | Periodontitis (occurrence or prevalence) | not extracted yet |
| Sanders 2015 Periodontitis and Sleep Disordered Breathing in the Hispanic Community Health Study/Study of Latinos. PMID:25669183 | 2015 | this review only | Periodontitis (occurrence or prevalence) | not extracted yet |
| Seo 2013 The association between periodontitis and obstructive sleep apnea: a preliminary study DOI:10.1111/jre.12032 | 2012 | this review only | Periodontitis (occurrence or prevalence) | not extracted yet |
| Stazic 2022 Periodontitis severity in obstructive sleep apnea patients DOI:10.1007/s00784-021-04012-5 | 2021 | this review only | Periodontal disease severity (Spearman correlation with OSA) | not extracted yet |
| Tellez Corral 2023 Cryptic Oral Microbiota: What Is Its Role as Obstructive Sleep Apnea-Related Periodontal Pathogens? PMID:36767109 | 2023 | this review only | Periodontitis (occurrence or prevalence) | not extracted yet |
| Tellez-Corral 2022 Patients with obstructive sleep apnea can favor the predisposing factors of periodontitis by the presence of P. melaninogenica and C.… PMID:36189359 | 2022 | this review only | Periodontitis (occurrence or prevalence) | not extracted yet |
| Tranfic Duplancic 2022 Salivary parameters and periodontal inflammation in obstructive sleep apnoea patients DOI:10.1038/s41598-022-23957-5 | 2022 | this review only | Periodontal disease severity (Spearman correlation with OSA) | not extracted yet |
| Verhelst 2022 Screening for the Risk of OSA in Periodontitis Patients. A Pilot Study. PMID:35695694 | 2022 | this review only | Periodontitis (occurrence or prevalence) | not extracted yet |
| Ytzhaik 2023 Obstructive Sleep Apnea, Metabolic Dysfunction, and Periodontitis-Machine Learning and Statistical Analyses of the Dental, Oral, Medical… PMID:37233636 | 2023 | this review only | Periodontitis (occurrence or prevalence) | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Human adults aged 18 years or older in whom both OSA and periodontal status were assessed | Adults; sample sizes 52 to 132,354; 23 studies from 14 countries (n=23) |
| Intervention | Exposure: presence or severity of OSA by polysomnography, home sleep or cardiorespiratory monitoring with AHI, or validated questionnaires (STOP-BANG, Berlin) | OSA assessed by PSG, portable polygraphy, STOP, STOP-Bang, Berlin or Philips questionnaires (n=23) |
| Comparison | Participants without OSA or with subclinical apnea according to study thresholds | Non-OSA or low-risk participants (n=23) |
| Outcomes | Occurrence or prevalence of periodontitis; periodontal measures (PPD, CAL, BOP, alveolar bone loss); associations as OR, RR or Spearman/Pearson correlation | Periodontitis: pooled OR 2.22 (95% CI 1.78 to 2.77), 18 studies; Spearman correlation with periodontal severity r 0.39 (95% CI 0.17 to 0.58), 5 studies |
| Study designs | Observational studies (cross-sectional, case-control, cohort, longitudinal), English language | Cross-sectional (n=17) and case-control (n=6) studies |
| Timing | Not specified | Not specified |