Non-Cochrane · prognostic · PM41976368
Prognostic Factors and Survival Outcomes in Parotid Gland Mucoepidermoid Carcinoma: A Systematic Review with Meta-Analysis and Workflow Proposal.
Salzano Giovanni, Scocca Veronica, Vaira Luigi Angelo, et al. · Cancers · 2026 · PubMed · doi:10.3390/cancers18071146
Findings
Population Patients with primary parotid gland mucoepidermoid carcinoma
52 findings
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | 5-year overall survival 5 years · Not specified · Sensitivity analysis: leave-one-out, omitting Chan SA 2021 | Proportion 0.8 [0.8, 0.9] GRADE not reported 9 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | 10-year overall survival 10 years · Not specified · Sensitivity analysis: leave-one-out, omitting Chan SA 2021 | Proportion 0.7 [0.7, 0.7] GRADE not reported 5 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | 10-year disease-specific survival 10 years · Not specified · Sensitivity analysis: leave-one-out, omitting Fang Q 2019 | Proportion 0.9 [0.8, 0.9] GRADE not reported 4 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | 10-year overall survival 10 years · Not specified · Sensitivity analysis: leave-one-out, omitting Kokemueller H 2005 | Proportion 0.7 [0.7, 0.7] GRADE not reported 5 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | Regional recurrence Not specified · Not specified · Sensitivity analysis: leave-one-out, omitting Boahene DKO 2004 | Proportion 0 [0, 0.1] GRADE not reported 7 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | 1-year overall survival 1 year · Not specified | Proportion 1.0 [1.0, 1.0] GRADE not reported 3 studies · 1377 participants |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | Distant recurrence Not specified · Not specified · Sensitivity analysis: leave-one-out, omitting Boahene DKO 2004 | Proportion 0.1 [0, 0.1] GRADE not reported 5 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | Regional recurrence Not specified · Not specified · Sensitivity analysis: leave-one-out, omitting Niu X 2019 | Proportion 0 [0, 0] GRADE not reported 7 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | Distant recurrence Not specified · Not specified · Sensitivity analysis: leave-one-out, omitting Grasl S 2022 | Proportion 0.1 [0.1, 0.2] GRADE not reported 5 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | Regional recurrence Not specified · Not specified · Sensitivity analysis: leave-one-out, omitting Laudadio P 1987 | Proportion 0 [0, 0.1] GRADE not reported 7 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | 10-year disease-specific survival 10 years · Not specified · Sensitivity analysis: leave-one-out, omitting Chan SA 2021 | Proportion 0.9 [0.8, 0.9] GRADE not reported 4 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | Distant recurrence Not specified · Not specified · Sensitivity analysis: leave-one-out, omitting Rapidis AD 2007 | Proportion 0 [0, 0.1] GRADE not reported 5 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | Local recurrence Not specified · Not specified · Sensitivity analysis: leave-one-out, omitting Niu X 2019 | Proportion 0.1 [0.1, 0.1] GRADE not reported 8 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | Local recurrence Not specified · Not specified · Sensitivity analysis: leave-one-out, omitting Chen AM 2013 | Proportion 0.1 [0.1, 0.1] GRADE not reported 8 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | 5-year overall survival 5 years · Not specified · Sensitivity analysis: leave-one-out, omitting Grasl S 2022 | Proportion 0.8 [0.8, 0.9] GRADE not reported 9 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | 10-year disease-specific survival 10 years · Not specified | Proportion 0.9 [0.7, 1.0] GRADE not reported 5 studies · 1594 participants |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | Regional recurrence Not specified · Not specified · Sensitivity analysis: leave-one-out, omitting Kokemueller H 2005 | Proportion 0 [0, 0.1] GRADE not reported 7 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | 5-year overall survival 5 years · Not specified · Sensitivity analysis: leave-one-out, omitting Janz TA 2018 | Proportion 0.8 [0.8, 0.9] GRADE not reported 9 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | 5-year overall survival 5 years · Not specified | Proportion 0.9 [0.8, 0.9] GRADE not reported 10 studies · 2341 participants |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | Local recurrence Not specified · Not specified · Sensitivity analysis: leave-one-out, omitting Laudadio P 1987 | Proportion 0.1 [0.1, 0.1] GRADE not reported 8 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | 10-year overall survival 10 years · Not specified · Sensitivity analysis: leave-one-out, omitting Boahene DKO 2004 | Proportion 0.7 [0.7, 0.7] GRADE not reported 5 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | Regional recurrence Not specified · Not specified · Sensitivity analysis: leave-one-out, omitting Emerick KS 2007 | Proportion 0 [0, 0.1] GRADE not reported 7 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | 5-year overall survival 5 years · Not specified · Sensitivity analysis: leave-one-out, omitting Chen AM 2013 | Proportion 0.8 [0.8, 0.9] GRADE not reported 9 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | 5-year overall survival 5 years · Not specified · Sensitivity analysis: leave-one-out, omitting Bhattacharyya N 2005 | Proportion 0.9 [0.8, 0.9] GRADE not reported 9 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | 10-year overall survival 10 years · Not specified · Sensitivity analysis: leave-one-out, omitting Suzuki M 1998 | Proportion 0.7 [0.7, 0.7] GRADE not reported 5 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | 10-year disease-specific survival 10 years · Not specified · Sensitivity analysis: leave-one-out, omitting Sun J 2019 | Proportion 0.9 [0.8, 0.9] GRADE not reported 4 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | 5-year overall survival 5 years · Not specified · Sensitivity analysis: leave-one-out, omitting Boahene DKO 2004 | Proportion 0.8 [0.8, 0.9] GRADE not reported 9 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | 10-year disease-specific survival 10 years · Not specified · Sensitivity analysis: leave-one-out, omitting Boahene DKO 2004 | Proportion 0.9 [0.8, 0.9] GRADE not reported 4 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | Regional recurrence Not specified · Not specified | Proportion 0.0 [0.0, 0.1] GRADE not reported 8 studies · 584 participants |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | 10-year overall survival 10 years · Not specified · Sensitivity analysis: leave-one-out, omitting Bhattacharyya N 2005 | Proportion 0.7 [0.7, 0.8] GRADE not reported 5 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | Regional recurrence Not specified · Not specified · Sensitivity analysis: leave-one-out, omitting Suzuki M 1998 | Proportion 0 [0, 0.1] GRADE not reported 7 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | Local recurrence Not specified · Not specified · Sensitivity analysis: leave-one-out, omitting Emerick KS 2007 | Proportion 0.1 [0.1, 0.1] GRADE not reported 8 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | 5-year overall survival 5 years · Not specified · Sensitivity analysis: leave-one-out, omitting Mao M 2017 | Proportion 0.8 [0.8, 0.9] GRADE not reported 9 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | Distant recurrence Not specified · Not specified · Sensitivity analysis: leave-one-out, omitting Laudadio P 1987 | Proportion 0.1 [0, 0.1] GRADE not reported 5 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | 5-year overall survival 5 years · Not specified · Sensitivity analysis: leave-one-out, omitting Sun J 2019 | Proportion 0.9 [0.8, 0.9] GRADE not reported 9 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | 10-year disease-specific survival 10 years · Not specified · Sensitivity analysis: leave-one-out, omitting Kawata R 2023 | Proportion 0.9 [0.9, 0.9] GRADE not reported 4 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | Local recurrence Not specified · Not specified · Sensitivity analysis: leave-one-out, omitting Kokemueller H 2005 | Proportion 0.1 [0.1, 0.1] GRADE not reported 8 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | 5-year disease-specific survival 5 years · Not specified | Proportion 1.0 [0.2, 1.0] GRADE not reported 4 studies · 1465 participants |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | Local recurrence Not specified · Not specified · Sensitivity analysis: leave-one-out, omitting Suzuki M 1998 | Proportion 0.1 [0.1, 0.1] GRADE not reported 8 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | 5-year overall survival 5 years · Not specified · Sensitivity analysis: leave-one-out, omitting Kokemueller H 2005 | Proportion 0.9 [0.8, 0.9] GRADE not reported 9 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | Regional recurrence Not specified · Not specified · Sensitivity analysis: leave-one-out, omitting Rapidis AD 2007 | Proportion 0 [0, 0.1] GRADE not reported 7 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | Distant recurrence Not specified · Not specified · Sensitivity analysis: leave-one-out, omitting Suzuki M 1998 | Proportion 0 [0, 0.1] GRADE not reported 5 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | 5-year overall survival 5 years · Not specified · Sensitivity analysis: leave-one-out, omitting Suzuki M 1998 | Proportion 0.8 [0.8, 0.9] GRADE not reported 9 studies |
| Any surgical or non-surgical treatment (single-arm; mostly parotidectomy with or without neck dissection and postoperative radiotherapy) | None (single-arm) | Distant recurrence Follow-up of included studies (mean 72.6 months overall) | Pooled proportion (%) 10 [0, 40] GRADE not reported 6 studies · 352 participants |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | Local recurrence Not specified · Not specified · Sensitivity analysis: leave-one-out, omitting Rapidis AD 2007 | Proportion 0.1 [0.1, 0.1] GRADE not reported 8 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | Local recurrence Not specified · Not specified · Sensitivity analysis: leave-one-out, omitting Grasl S 2022 | Proportion 0.1 [0.1, 0.1] GRADE not reported 8 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | Distant recurrence Not specified · Not specified · Sensitivity analysis: leave-one-out, omitting Emerick KS 2007 | Proportion 0 [0, 0.1] GRADE not reported 5 studies |
| Any surgical or non-surgical treatment (single-arm; mostly parotidectomy with or without neck dissection and postoperative radiotherapy) | None (single-arm) | 10-year overall survival 10 years | Pooled proportion (%) 70 [40, 80] GRADE not reported 6 studies · 1875 participants |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | Local recurrence Not specified · Not specified · Sensitivity analysis: leave-one-out, omitting Boahene DKO 2004 | Proportion 0.1 [0.1, 0.1] GRADE not reported 8 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | Regional recurrence Not specified · Not specified · Sensitivity analysis: leave-one-out, omitting Grasl S 2022 | Proportion 0 [0, 0.1] GRADE not reported 7 studies |
| Any treatment (mainly parotidectomy with or without neck dissection and postoperative radiotherapy); single-arm | None (single-arm pooled proportion) | 10-year overall survival 10 years · Not specified · Sensitivity analysis: leave-one-out, omitting Sun J 2019 | Proportion 0.7 [0.6, 0.7] GRADE not reported 5 studies |
| Any surgical or non-surgical treatment (single-arm; mostly parotidectomy with or without neck dissection and postoperative radiotherapy) | None (single-arm) | Local recurrence Follow-up of included studies (mean 72.6 months overall) | Pooled proportion (%) 10 [0, 20] GRADE not reported 9 studies · 645 participants |
Included primary studies 21
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Al-Qurayshi 2022 Presentation and outcomes of patients with clinically T1-2, N0 parotid mucoepidermoid carcinoma: The roles of elective neck dissection and… PMID:35731030 | 2022 | this review only | not stated | not extracted yet |
| Bhattacharyya 2005 Determinants of survival in parotid gland carcinoma: a population-based study. PMID:15635580 | 2005 | this review only | 5-year overall survival; 10-year overall survival | not extracted yet |
| Boahene 2004 Mucoepidermoid carcinoma of the parotid gland: the Mayo clinic experience. PMID:15262762 | 2004 | this review only | 5-year overall survival; 10-year overall survival; 5-year disease-specific survival; 10-year disease-specific survival; Local recurrence; Regional recurrence; Distant recurrence | not extracted yet |
| Chan 2021 Mucoepidermoid carcinoma of the parotid gland: Twenty-year experience in treatment and outcomes. PMID:33931913 | 2021 | this review only | 1-year overall survival; 5-year overall survival; 10-year overall survival; 5-year disease-specific survival; 10-year disease-specific survival | not extracted yet |
| Chen AM 2013 Mucoepidermoid carcinoma of the parotid gland treated by surgery and postoperative radiation therapy: clinicopathologic correlates of… PMID:23754320 | 2013 | this review only | 5-year overall survival; Local recurrence | not extracted yet |
| Chen MM 2014 Histologic grade as prognostic indicator for mucoepidermoid carcinoma: a population-level analysis of 2400 patients. PMID:23765800 | 2014 | this review only | not stated | not extracted yet |
| Emerick 2007 Clinical presentation, management, and outcome of high-grade mucoepidermoid carcinoma of the parotid gland. PMID:17478216 | 2007 | this review only | 5-year disease-specific survival; Local recurrence; Regional recurrence; Distant recurrence | not extracted yet |
| Fang 2019 Oncologic outcome of parotid mucoepidermoid carcinoma in pediatric patients. PMID:30774436 | 2019 | this review only | 10-year disease-specific survival | not extracted yet |
| Grasl 2022 Influence of Grading on Management and Outcome in Mucoepidermoid Carcinoma of the Parotid-A Multi-institutional Analysis. PMID:35475580 | 2023 | this review only | 5-year overall survival; Local recurrence; Regional recurrence; Distant recurrence | not extracted yet |
| Janz 2018 Has the management of pediatric mucoepidermoid carcinoma of the parotid gland changed? PMID:29658113 | 2018 | this review only | 5-year overall survival | not extracted yet |
| Kawata 2023 Clinicopathological characteristics of four major histological types of high-grade parotid carcinoma. PMID:37831230 | 2023 | this review only | 10-year disease-specific survival | not extracted yet |
| Kokemueller 2005 Mucoepidermoid carcinoma of the salivary glands--clinical review of 42 cases. PMID:15598579 | 2005 | this review only | 5-year overall survival; 10-year overall survival; Local recurrence; Regional recurrence | not extracted yet |
| Laudadio 1987 Mucoepidermoid tumour of the parotid gland: a very difficult prognostic evaluation. PMID:3608208 | 1987 | this review only | Local recurrence; Regional recurrence; Distant recurrence | not extracted yet |
| Li 2023 Number of positive lymph nodes is superior to neck stage of the 8th AJCC in predicting prognosis in parotid mucoepidermoid carcinoma. PMID:37594176 | 2023 | this review only | not stated | not extracted yet |
| Mao 2017 Surgery combined with postoperative 125 I seed brachytherapy for the treatment of mucoepidermoid carcinoma of the parotid gland in… PMID:27576792 | 2017 | this review only | 5-year overall survival | not extracted yet |
| Niu 2019 Role of intraparotid node metastasis in mucoepidermoid carcinoma of the parotid gland. PMID:31053107 | 2019 | this review only | Local recurrence; Regional recurrence | not extracted yet |
| Rahbar 2006 Mucoepidermoid carcinoma of the parotid gland in children: A 10-year experience. PMID:16618905 | 2006 | this review only | not stated | not extracted yet |
| Rapidis 2007 Mucoepidermoid carcinoma of the salivary glands. Review of the literature and clinicopathological analysis of 18 patients. PMID:16857410 | 2007 | this review only | Local recurrence; Regional recurrence; Distant recurrence | not extracted yet |
| Shang 2019 Deep Parotid Lymph Node Metastasis Is Associated With Recurrence in High-Grade Mucoepidermoid Carcinoma of the Parotid Gland. PMID:30794816 | 2019 | this review only | not stated | not extracted yet |
| Sun 2019 Nomogram to predict the prognosis of parotid gland mucoepidermoid carcinoma: a population-based study of 1306 cases. PMID:31304070 | 2019 | this review only | 1-year overall survival; 5-year overall survival; 10-year overall survival; 5-year disease-specific survival; 10-year disease-specific survival | not extracted yet |
| Suzuki 1998 Histological features and prognosis of patients with mucoepidermoid carcinoma of the parotid gland. PMID:10211217 | 1998 | this review only | 1-year overall survival; 5-year overall survival; 10-year overall survival; Local recurrence; Regional recurrence; Distant recurrence | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients with primary parotid gland mucoepidermoid carcinoma | 7192 patients with primary parotid MEC (n=7192) |
| Intervention | Any surgical or non-surgical intervention (parotidectomy, neck dissection, radiotherapy, chemoradiotherapy, targeted therapies) | Total parotidectomy (n=2606), superficial parotidectomy (n=1642), neck dissection (n=1744), postoperative radiotherapy (n=3413) |
| Comparison | None | None |
| Outcomes | 1, 5 and 10-year OS and DFS; local, regional and distant recurrence; prognostic factors; treatment strategies | 1, 5 and 10-year OS; 5 and 10-year DSS; local, regional and distant recurrence |
| Study designs | Retrospective and prospective cohort, case-control and cross-sectional studies and RCTs | 21 retrospective studies |
| Timing | Not specified | Mean follow-up 72.6 months |