Non-Cochrane · aetiology · PM41862530
Assessment of genetic susceptibility in patients with oral squamous cell carcinoma: a systematic review and meta-analysis.
Jadhav Kiran, Pateel Deepak G S, Grover Sonal, et al. · Communications medicine · 2026 · PubMed · doi:10.1038/s43856-026-01398-9
Findings
93 findings
| Population | ||||
|---|---|---|---|---|
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | TNF gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Tobacco smoking | TNF, tobacco smoking: Z = 8.30, heterogeneity I2 = 78%, p = <0.00001 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | TNF polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC | OR 1.77 [0.83, 3.78] GRADE not reported 5 studies · 5804 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | TNF gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Alcohol | TNF, alcohol: Z = 1.32, heterogeneity I2 = 83%, p = 0.19 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | TNF gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Tobacco chewing | TNF, tobacco chewing: Z = 0.90, heterogeneity I2 = 0%, p = 0.37 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | P73 polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC | OR 0.48 [0.10, 2.42] GRADE not reported 2 studies · 3093 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | miRNA polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC | OR 1.37 [1.10, 1.70] GRADE not reported 9 studies · 27099 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | miRNA gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Tobacco chewing | miRNA, tobacco chewing: Z = 1.05, heterogeneity I2 = 96%, p = 0.29 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | miRNA gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Tobacco smoking | miRNA, tobacco smoking: Z = 0.95, heterogeneity I2 = 94%, p = 0.34 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | miRNA gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Alcohol | miRNA, alcohol: Z = 1.10, heterogeneity I2 = 95%, p = 0.27 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | CYP1A1 polymorphism (CYP1) | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC Mixed habit (tobacco and alcohol) | OR 1.87 [1.26, 2.76] GRADE not reported 1 study · 903 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | CYP1A1 polymorphism (CYP1) | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC Tobacco chewing | OR 0.24 [0.15, 0.38] GRADE not reported 2 studies · 4179 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | CYP1A1 polymorphism (CYP1) | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC Tobacco smoking | OR 0.66 [0.42, 1.06] GRADE not reported 8 studies · 6976 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | CYP1A1 polymorphism (CYP1) | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC | OR 1.50 [1.03, 2.19] GRADE not reported 13 studies · 11258 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | CYP1A1 polymorphism (CYP1) | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC Alcohol | OR 0.72 [0.44, 1.17] GRADE not reported 4 studies · 3948 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | CYP1A1 polymorphism (CYP1) | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC All habit subgroups combined (smoking, chewing, alcohol, mixed) | OR 0.60 [0.45, 0.80] GRADE not reported 8 studies · 16006 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | MTHFR polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC | OR 1.04 [0.62, 1.76] GRADE not reported 5 studies · 4554 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | GSTM gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Tobacco chewing | GSTM, tobacco chewing: Z = 25.94, heterogeneity I2 = 96%, p = <0.00001 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | GSTM gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Tobacco smoking | GSTM, tobacco smoking: Z = 24.32, heterogeneity I2 = 94%, p = <0.00001 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | GSTM polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC | OR 1.08 [0.83, 1.41] GRADE not reported 11 studies · 17571 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | GSTM gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Alcohol | GSTM, alcohol: Z = 22.73, heterogeneity I2 = 94%, p = <0.00001 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | UGT gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Tobacco smoking | UGT, tobacco smoking: Z = 3.80, heterogeneity I2 = 91%, p = 0.0001 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | UGT gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Alcohol | UGT, alcohol: Z = 2.30, heterogeneity I2 = 47%, p = 0.02 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | UGT polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC | OR 1.32 [0.93, 1.87] GRADE not reported 2 studies · 1057 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | Interleukin polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC | OR 1.13 [0.81, 1.58] GRADE not reported 8 studies · 9753 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | Interleukin gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Alcohol | Interleukin, alcohol: Z = 1.65, heterogeneity I2 = 65%, p = 0.10 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | Interleukin gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Tobacco chewing | Interleukin, tobacco chewing: Z = 1.20, heterogeneity I2 = 67%, p = 0.20 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | Interleukin gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Tobacco smoking | Interleukin, tobacco smoking: Z = 0.88, heterogeneity I2 = 87%, p = 0.38 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | VEGF polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC | OR 1.37 [0.94, 2.02] GRADE not reported 2 studies · 2683 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | MMP gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Alcohol | MMP, alcohol: Z = 0.26, heterogeneity I2 = 49%, p = 0.80 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | MMP gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Tobacco chewing | MMP, tobacco chewing: Z = 0.12, heterogeneity I2 = 64%, p = 0.90 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | MMP polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC | OR 1.05 [0.90, 1.23] GRADE not reported 5 studies · 24900 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | MMP gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Tobacco smoking | MMP, tobacco smoking: Z = 0.10, heterogeneity I2 = 84%, p = 0.92 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | E-cadherin polymorphism | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC | OR 1.81 [0.90, 3.65] GRADE not reported 1 study · 2392 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | Ecadherin gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Tobacco smoking | Ecadherin, tobacco smoking: Z = 1.95, heterogeneity I2 = 91%, p = 0.05 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | Ecadherin gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Tobacco chewing | Ecadherin, tobacco chewing: Z = 0.53, heterogeneity I2 = 94%, p = 0.60 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | CASP8 polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC | OR 1.13 [0.81, 1.58] GRADE not reported 4 studies · 16740 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | CASP8 polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC Smoking and alcohol subgroups combined | OR 1.84 [1.48, 2.29] GRADE not reported 6 studies · 18384 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | CASP8 polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC Tobacco smoking | OR 2.17 [1.52, 3.11] GRADE not reported 4 studies · 10388 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | CASP8 polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC Alcohol | OR 1.45 [1.26, 1.67] GRADE not reported 4 studies · 7996 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | XRCC1 polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC | OR 1.11 [0.90, 1.36] GRADE not reported 6 studies · 8993 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | XRCC1 gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Alcohol | XRCC1, alcohol: Z = 11.70, heterogeneity I2 = not applicable, p = <0.00001 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | XRCC1 gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Tobacco chewing | XRCC1, tobacco chewing: Z = 1.23, heterogeneity I2 = 98%, p = 0.22 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | XRCC1 gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Tobacco smoking | XRCC1, tobacco smoking: Z = 0.99, heterogeneity I2 = 98%, p = 0.32 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | MGMT polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC | OR 0.91 [0.73, 1.13] GRADE not reported 3 studies · 3934 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | P53 polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC Mixed habit (tobacco and alcohol) | Z = 3.28; I2 = 47%; p = 0.001 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | P53 polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC Smoking and alcohol subgroups combined (labelled mixed habit in Table 3) | OR 1.35 [1.13, 1.61] GRADE not reported 3 studies · 28916 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | P53 polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC Alcohol | OR 1.37 [1.06, 1.77] GRADE not reported 3 studies · 14543 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | P53 polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC Tobacco smoking | OR 1.35 [1.03, 1.76] GRADE not reported 3 studies · 14373 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | P53 polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC | OR 1.03 [0.43, 2.43] GRADE not reported 5 studies · 4265 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | ADAM1 gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Tobacco chewing | ADAM1, tobacco chewing: Z = 0.00, heterogeneity I2 = 0%, p = 1.00 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | ADAM1 gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Tobacco smoking | ADAM1, tobacco smoking: Z = 0.00, heterogeneity I2 = 0%, p = 1.00 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | ADAM1 polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC | OR 1.03 [0.85, 1.24] GRADE not reported 1 study · 44403 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | LTF polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC | OR 0.88 [0.55, 1.42] GRADE not reported 1 study · 1936 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | MT polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC | OR 1.29 [0.79, 2.10] GRADE not reported 1 study · 824 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | XPD polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC | OR 1.18 [0.84, 1.65] GRADE not reported 3 studies · 3219 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | NFKB polymorphism | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC | OR 3.90 [1.27, 11.95] GRADE not reported 1 study · 237 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | IGF2 polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC | OR 1.20 [0.67, 2.16] GRADE not reported 1 study · 20376 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | lncRNA polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC | OR 1.09 [0.96, 1.23] GRADE not reported 3 studies · 30597 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | lncRNA gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Tobacco smoking | lncRNA, tobacco smoking: Z = 1.13, heterogeneity I2 = 93%, p = 0.26 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | lncRNA gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Alcohol | lncRNA, alcohol: Z = 0.02, heterogeneity I2 = 20%, p = 0.98 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | TLR polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC | OR 1.04 [0.88, 1.23] GRADE not reported 2 studies · 3801 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | WISP polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC | OR 1.00 [0.95, 1.05] GRADE not reported 1 study · 37800 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | COX2 gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Tobacco smoking | COX2, tobacco smoking: Z = 1.66, heterogeneity I2 = 97%, p = 0.10 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | COX2 polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC | OR 1.32 [0.50, 3.44] GRADE not reported 2 studies · 5205 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | COX2 gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Alcohol | COX2, alcohol: Z = 1.22, heterogeneity I2 = 98%, p = 0.22 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | Survivin polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC | OR 1.05 [0.81, 1.37] GRADE not reported 2 studies · 1184 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | RAD5 polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC | OR 0.70 [0.20, 2.52] GRADE not reported 2 studies · 3626 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | ADH1C polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC | OR 1.92 [0.57, 6.51] GRADE not reported 3 studies · 4367 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | ADH1C gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Alcohol | ADH1C, alcohol: Z = 1.98, heterogeneity I2 = 69%, p = 0.05 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | ADH1C gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Tobacco smoking | ADH1C, tobacco smoking: Z = 0.02, heterogeneity I2 = 0%, p = 0.98 GRADE not reported Studies not reported |
| Patients with OSCC and controls reporting family history | Positive family history | No family history | Presence of gene polymorphism (OSCC susceptibility) | OR 0.70 [0.23, 2.18] GRADE not reported 7 studies · 2924 participants |
| Patients with OSCC and controls with chronic mucosal trauma | Chronic mucosal trauma | No chronic mucosal trauma | Presence of gene polymorphism (OSCC susceptibility) | OR 1.38 [0.28, 6.87] GRADE not reported 2 studies · 538 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | FUT gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Tobacco chewing | FUT, tobacco chewing: Z = 0.26, heterogeneity I2 = 50%, p = 0.79 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | FUT gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Tobacco smoking | FUT, tobacco smoking: Z = 5.51, heterogeneity I2 = 89%, p = <0.00001 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | MTNR1 gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Tobacco chewing | MTNR1, tobacco chewing: Z = 4.30, heterogeneity I2 = 0%, p = <0.00001 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | MTNR1 gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Tobacco smoking | MTNR1, tobacco smoking: Z = 12.12, heterogeneity I2 = 0%, p = <0.00001 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | HIF polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC Tobacco chewing | OR 5.33 [0.68, 41.82] GRADE not reported 1 study · 186 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | HIF polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC Smoking and chewing subgroups combined | OR 7.19 [2.16, 23.89] GRADE not reported 1 study · 708 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | HIF polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC Tobacco smoking | OR 8.39 [1.92, 36.75] GRADE not reported 1 study · 522 participants |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | MASPIN gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Tobacco chewing | MASPIN, tobacco chewing: Z = 0.94, heterogeneity I2 = 11%, p = 0.34 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | MASPIN gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Alcohol | MASPIN, alcohol: Z = 1.95, heterogeneity I2 = 73%, p = 0.05 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | MASPIN gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Tobacco smoking | MASPIN, tobacco smoking: Z = 1.45, heterogeneity I2 = 1%, p = 0.15 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | RECK gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Tobacco smoking | RECK, tobacco smoking: Z = 6.67, heterogeneity I2 = 65%, p = <0.00001 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | Leptin gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Tobacco smoking | Leptin, tobacco smoking: Z = 1.05, heterogeneity I2 = 81%, p = 0.30 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | Leptin gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Alcohol | Leptin, alcohol: Z = 1.05, heterogeneity I2 = 82%, p = 0.29 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | Leptin gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Tobacco chewing | Leptin, tobacco chewing: Z = 1.41, heterogeneity I2 = 0%, p = 0.16 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | CA9 gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Tobacco smoking | CA9, tobacco smoking: Z = 4.84, heterogeneity I2 = 61%, p = <0.00001 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | ALDH1 gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Tobacco smoking | ALDH1, tobacco smoking: Z = 0.69, heterogeneity I2 = 87%, p = 0.49 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls | ALDH1 gene polymorphism or alteration | Controls without OSCC (reference genotype or expression) | Susceptibility (risk) of developing OSCC Alcohol | ALDH1, alcohol: Z = 3.64, heterogeneity I2 = 59%, p = 0.0003 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | CA9 polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC Tobacco chewing | Z = 1.53; I2 = 0%; p = 0.13 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | DEC1 polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC Alcohol | Z = 4.42; I2 = 0%; p <0.00001 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | DEC1 polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC Tobacco smoking | Z = 10.46; I2 = 7%; p <0.00001 GRADE not reported Studies not reported |
| Patients with histologically diagnosed oral squamous cell carcinoma (OSCC) and controls without OSCC | RECK polymorphism or abnormality | Controls without OSCC (reference genotype or allele) | Susceptibility to (odds of) OSCC Tobacco chewing Unresolved: the two extractors disagree on this row. | Z = 0.95; I2 = 45%; p = 0.05 GRADE not reported Studies not reported |
Included primary studies 196
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Wang 2020 matched by author and year (probable) | NR | 5 other reviews | not stated | not extracted yet |
| Zhang 2017 matched by author and year (probable) | NR | 2 other reviews | not stated | not extracted yet |
| Kao 2002 Genetic polymorphism of cytochrome P4501A1 and susceptibility to oral squamous cell carcinoma and oral precancer lesions associated with… PMID:12269988 | 2002 | 1 other review | not stated | not extracted yet |
| Majumder 2005 Increased risk of oral leukoplakia and cancer among mixed tobacco users carrying XRCC1 variant haplotypes and cancer among smokers… PMID:16172217 | 2005 | 1 other review | not stated | not extracted yet |
| Miao 2016 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| Miao 2016 Association of microRNA polymorphisms with the risk of head and neck squamous cell carcinoma in a Chinese population: a case-control study. PMID:27515039 | 2016 | 1 other review | not stated | not extracted yet |
| Shukla 2012 Genetic polymorphism of drug metabolizing enzymes (GSTM1 and CYP1A1) as risk factors for oral premalignant lesions and oral cancer. PMID:22660220 | 2012 | 1 other review | not stated | not extracted yet |
| Singh 2014 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| Werbrouck 2008 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| Yang 2016 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| Amtha 2009 GSTM1, GSTT1 and CYP1A1 polymorphisms and risk of oral cancer: a case-control study in Jakarta, Indonesia. PMID:19469619 | 2009 | this review only | not stated | not extracted yet |
| An 2007 Potentially functional single nucleotide polymorphisms in the core nucleotide excision repair genes and risk of squamous cell carcinoma of… PMID:17684138 | 2007 | this review only | not stated | not extracted yet |
| Anil 2016 Association of Poly (ADP-Ribose) Polymerase 1 Variants with Oral Squamous Cell Carcinoma Susceptibility in a South Indian Population. PMID:27644669 | 2016 | this review only | not stated | not extracted yet |
| Avci 2018 Are XPD and XPG gene variants related to the mechanism of oral squamous cell carcinoma? PMID:30672443 | 2018 | this review only | not stated | not extracted yet |
| Balaji 2011 Genetic polymorphisms of the CYP2E1 gene do not contribute to oral cancer susceptibility in south Indians. PMID:22126492 | 2011 | this review only | not stated | not extracted yet |
| Barbosa 2016 Polymorphisms in methylenetetrahydrofolate reductase and cystathionine beta-synthase in oral cancer - a case-control study in southeastern… PMID:26749456 | 2016 | this review only | not stated | not extracted yet |
| Bau 2007 Association of p53 and p21(CDKN1A/WAF1/CIP1) polymorphisms with oral cancer in Taiwan patients. PMID:17595776 | 2007 | this review only | not stated | not extracted yet |
| Bau 2010 Association between DNA repair gene ATM polymorphisms and oral cancer susceptibility. PMID:21108427 | 2010 | this review only | not stated | not extracted yet |
| Bharti 2013 Functional genetic variants of CTLA-4 and risk of tobacco-related oral carcinoma in high-risk North Indian population. PMID:23246583 | 2013 | this review only | not stated | not extracted yet |
| Borkotoky 2020 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Borkotoky 2020 Alterations in XRCC1 gene profile in pathogenesis of oral cavity cancer: A population-based study from Kamrup Urban District of Assam,… PMID:30954277 | 2020 | this review only | not stated | not extracted yet |
| Brierly 2023 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Brierly 2023 Tumour Necrosis Factor Alpha (TNF-α) and Oral Squamous Cell Carcinoma. PMID:36980727 | 2023 | this review only | not stated | not extracted yet |
| Brocic 2011 Genetic polymorphisms of ADH1C and CYP2E1 and risk of oral squamous cell carcinoma. PMID:21705789 | 2011 | this review only | not stated | not extracted yet |
| Buch 2002 Polymorphism at GSTM1, GSTM3 and GSTT1 gene loci and susceptibility to oral cancer in an Indian population. PMID:12016153 | 2002 | this review only | not stated | not extracted yet |
| Cacına 2023 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Cacına 2023 The analysis of Survivin promoter (-31G/C) gene variation in oral squamous cell carcinoma risk and prognosis. PMID:37164127 | 2023 | this review only | not stated | not extracted yet |
| Cao 2006 A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter enhances oral squamous cell carcinoma susceptibility in a… PMID:16256416 | 2006 | this review only | not stated | not extracted yet |
| Cha 2007 Polymorphisms of CYP1A1 and GSTM1 genes and susceptibility to oral cancer. PMID:17461521 | 2007 | this review only | not stated | not extracted yet |
| Chatterjee 2009 Prevalence of CYP1A1 and GST polymorphisms in the population of northeastern India and susceptibility of oral cancer. PMID:19718946 | 2009 | this review only | not stated | not extracted yet |
| Chen 2001 N-Acetyltransferase 2 polymorphisms, cigarette smoking and alcohol consumption, and oral squamous cell cancer risk. PMID:11751430 | 2001 | this review only | not stated | not extracted yet |
| Chen 2008 CASP3 polymorphisms and risk of squamous cell carcinoma of the head and neck. PMID:18829519 | 2008 | this review only | not stated | not extracted yet |
| Chen 2009 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Chen 2009 The association between hypoxia inducible factor-1alpha gene polymorphisms and increased susceptibility to oral cancer. PMID:19717330 | 2009 | this review only | not stated | not extracted yet |
| Chen 2011 CCR2-64I gene polymorphism increase susceptibility to oral cancer. PMID:21570337 | 2011 | this review only | not stated | not extracted yet |
| Chen 2018 A functional haplotype of NFKB1 influence susceptibility to oral cancer: a population-based and in vitro study. PMID:29635862 | 2018 | this review only | not stated | not extracted yet |
| Chen 2023 Potential impact of ADAM-10 genetic variants with the clinical features of oral squamous cell carcinoma. PMID:36946281 | 2023 | this review only | not stated | not extracted yet |
| Cheng 2016 Functional genetic variant in the Kozak sequence of WW domain-containing oxidoreductase (WWOX) gene is associated with oral cancer risk. PMID:27655721 | 2016 | this review only | not stated | not extracted yet |
| Chien 2012 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Chien 2012 Effects of E-cadherin (CDH1) gene promoter polymorphisms on the risk and clinicopathologic development of oral cancer. PMID:21472888 | 2012 | this review only | not stated | not extracted yet |
| Chien 2012 Interleukin-23 receptor polymorphism as a risk factor for oral cancer susceptibility. PMID:21717520 | 2012 | this review only | not stated | not extracted yet |
| Chien 2012 Impacts of CA9 gene polymorphisms and environmental factors on oral-cancer susceptibility and clinicopathologic characteristics in Taiwan. PMID:23226559 | 2012 | this review only | not stated | not extracted yet |
| Chien 2013 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Chien 2013 Impact of VEGF-C gene polymorphisms and environmental factors on oral cancer susceptibility in Taiwan. PMID:23593187 | 2013 | this review only | not stated | not extracted yet |
| Chiu 2008 A novel single nucleotide polymorphism in ERCC6 gene is associated with oral cancer susceptibility in Taiwanese patients. PMID:17933579 | 2008 | this review only | not stated | not extracted yet |
| Chou 2020 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Chou 2020 IGF2BP2 Polymorphisms Are Associated with Clinical Characteristics and Development of Oral Cancer. PMID:32784624 | 2020 | this review only | not stated | not extracted yet |
| Christensen 2010 Mature microRNA sequence polymorphism in MIR196A2 is associated with risk and prognosis of head and neck cancer. PMID:20501619 | 2010 | this review only | not stated | not extracted yet |
| Chu 2012 Impacts of microRNA gene polymorphisms on the susceptibility of environmental factors leading to carcinogenesis in oral cancer. PMID:22761899 | 2012 | this review only | not stated | not extracted yet |
| Chuang 2021 TRIM21 Polymorphisms are associated with Susceptibility and Clinical Status of Oral Squamous Cell Carcinoma patients. PMID:34220328 | 2021 | this review only | not stated | not extracted yet |
| Chung 2009 Sulfotransferase 1A1 haplotypes associated with oral squamous cell carcinoma susceptibility in male Taiwanese. PMID:19126640 | 2009 | this review only | not stated | not extracted yet |
| Chung 2011 Impact of RECK gene polymorphisms and environmental factors on oral cancer susceptibility and clinicopathologic characteristics in Taiwan. PMID:21565829 | 2011 | this review only | not stated | not extracted yet |
| D’Souza 2017 Multiple single nucleotide polymorphism analysis and association of specific genotypes in FHIT, SAMD4A, and ANKRD17 in Indian patients… PMID:28580594 | 2017 | this review only | not stated | not extracted yet |
| Damani Shah 2020 Single nucleotide polymorphisms in transcription factor genes associated with susceptibility to oral cancer. PMID:31452252 | 2020 | this review only | not stated | not extracted yet |
| Daripally 2015 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Daripally 2015 Susceptibility to oral cancers with CD95 and CD95L promoter SNPs may vary with the site and gender. PMID:25944167 | 2015 | this review only | not stated | not extracted yet |
| de Barros Gallo 2017 Toll-like receptor 2 rs4696480 polymorphism and risk of oral cancer and oral potentially malignant disorder. PMID:28624699 | 2017 | this review only | not stated | not extracted yet |
| de Freitas 2019 Polymorphisms associated with oral clefts as potential susceptibility markers for oral and breast cancer. PMID:30579133 | 2019 | this review only | not stated | not extracted yet |
| Ding 2022 Combined impacts of histamine receptor H1 gene polymorphisms and an environmental carcinogen on the susceptibility to and progression of… PMID:35587368 | 2022 | this review only | not stated | not extracted yet |
| Dos Reis 2013 Allelic variants of XRCC1 and XRCC3 repair genes and susceptibility of oral cancer in Brazilian patients. PMID:22775506 | 2013 | this review only | not stated | not extracted yet |
| Dos Santos Pereira 2016 Association of the XPD and XRCC3 gene polymorphisms with oral squamous cell carcinoma in a Northeastern Brazilian population: A pilot study. PMID:26742000 | 2016 | this review only | not stated | not extracted yet |
| Ertugrul 2023 The association of epidermal growth factor variant with oral squamous cell carcinoma. PMID:37658772 | 2023 | this review only | not stated | not extracted yet |
| Fernández-Mateos 2017 Analysis of autophagy gene polymorphisms in Spanish patients with head and neck squamous cell carcinoma. PMID:28761177 | 2017 | this review only | not stated | not extracted yet |
| Fernández-Mateos 2019 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Fernández-Mateos 2019 Genetic Susceptibility in Head and Neck Squamous Cell Carcinoma in a Spanish Population. PMID:30959967 | 2019 | this review only | not stated | not extracted yet |
| Francis 2020 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Francis 2020 Hypoxia responsiveness linked variant in EGLN1 gene is enriched in oral cancer patients. PMID:32464411 | 2020 | this review only | not stated | not extracted yet |
| Galbiatti 2010 The association between CBS 844ins68 polymorphism and head and neck squamous cell carcinoma risk - a case-control analysis. PMID:22419938 | 2010 | this review only | not stated | not extracted yet |
| Galbiatti 2012 Polymorphisms and haplotypes in methylenetetrahydrofolate reductase gene and head and neck squamous cell carcinoma risk. PMID:21556759 | 2012 | this review only | not stated | not extracted yet |
| Galíndez 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Galíndez 2021 DNA repair, NFKβ, and TP53 polymorphisms associated with potentially malignant disorders and oral squamous cell carcinoma in Argentine… PMID:33309268 | 2021 | this review only | not stated | not extracted yet |
| Gallì 2009 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Gallì 2009 A case-control study on the combined effects of p53 and p73 polymorphisms on head and neck cancer risk in an Italian population. PMID:19426493 | 2009 | this review only | not stated | not extracted yet |
| Ghapanchi 2020 The LncRNA H19 rs217727 Polymorphism Is Associated with Oral Squamous Cell Carcinoma Susceptibility in Iranian Population. PMID:32337223 | 2020 | this review only | not stated | not extracted yet |
| Gołąbek 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Gołąbek 2021 Selected E2F2 Polymorphisms in Oral and Oropharyngeal Squamous Cell Carcinoma. PMID:33860054 | 2021 | this review only | not stated | not extracted yet |
| Gołąbek 2022 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Gołąbek 2022 Single Nucleotide Polymorphism and mRNA Expression of LTF in Oral Squamous Cell Carcinoma. PMID:36360322 | 2022 | this review only | not stated | not extracted yet |
| Gu 2016 Telomere length, genetic variants and risk of squamous cell carcinoma of the head and neck in Southeast Chinese. PMID:26857734 | 2016 | this review only | not stated | not extracted yet |
| Guo 2017 LncRNA H19 polymorphisms associated with the risk of OSCC in Chinese population. PMID:28975993 | 2017 | this review only | not stated | not extracted yet |
| Hang 2017 Effects of potentially functional polymorphisms in suppressor of cytokine signaling 3 (SOCS3) on the risk of head and neck squamous cancer. PMID:27977878 | 2017 | this review only | not stated | not extracted yet |
| Holley 2005 Association of cyclin D1 polymorphism with increased susceptibility to oral squamous cell carcinoma. PMID:15695117 | 2005 | this review only | not stated | not extracted yet |
| Hou 2015 The association between miR-499a polymorphism and oral squamous cell carcinoma progression. PMID:24690080 | 2015 | this review only | not stated | not extracted yet |
| Hsieh 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Hsieh 2021 Genetic Variants of lncRNA GAS5 Are Associated with the Clinicopathologic Development of Oral Cancer. PMID:33925911 | 2021 | this review only | not stated | not extracted yet |
| Hsu 2009 Association between DNA double strand break gene Ku80 polymorphisms and oral cancer susceptibility. PMID:19217823 | 2009 | this review only | not stated | not extracted yet |
| Hua 2023 Analysis of MUC6 polymorphisms on the clinicopathologic characteristics of Asian patients with oral squamous cell carcinoma. PMID:37581476 | 2023 | this review only | not stated | not extracted yet |
| Huang 2010 O6-methylguanine-DNA methyltransferase gene coding region polymorphisms and oral cancer risk. PMID:20412404 | 2010 | this review only | not stated | not extracted yet |
| Huang 2010 A novel functional DEC1 promoter polymorphism -249T>C reduces risk of squamous cell carcinoma of the head and neck. PMID:20935061 | 2010 | this review only | not stated | not extracted yet |
| Huang 2019 Effects of APE1 Asp148Glu polymorphisms on OPMD malignant transformation, and on susceptibility to and overall survival of oral cancer in… PMID:30652382 | 2019 | this review only | not stated | not extracted yet |
| Huang 2019 Interactive effects of AURKA polymorphisms with smoking on the susceptibility of oral cancer. PMID:31174434 | 2019 | this review only | not stated | not extracted yet |
| Hung 2017 The Contribution of Matrix Metalloproteinase-8 Promoter Polymorphism to Oral Cancer Susceptibility. PMID:28652424 | 2017 | this review only | not stated | not extracted yet |
| Hung 2019 Leptin -2548 G/A polymorphisms are associated to clinical progression of oral cancer and sensitive to oral tumorization in nonsmoking… PMID:31021458 | 2019 | this review only | not stated | not extracted yet |
| Hussain 2016 Association of Interleukin-10 (A1082G) gene polymorphism with Oral squamous cell carcinoma in north Indian population. PMID:27350666 | 2016 | this review only | not stated | not extracted yet |
| Jha 2023 Polymorphisms and haplotypes of TLR-4/9 associated with bacterial infection, gingival inflammation/recession and oral cancer. PMID:36563560 | 2023 | this review only | not stated | not extracted yet |
| Ji 2011 ADH1B and ALDH2 polymorphisms and their associations with increased risk of squamous cell carcinoma of the head and neck in the Korean… PMID:21576033 | 2011 | this review only | not stated | not extracted yet |
| Jing 2012 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Jing 2012 The p53 codon 72 polymorphism and the risk of oral cancer in a Chinese Han population. PMID:22856646 | 2012 | this review only | not stated | not extracted yet |
| Katiyar 2020 Interaction of glutathione-s-transferase genotypes with environmental risk factors in determining susceptibility to head and neck cancer… PMID:32067264 | 2020 | this review only | not stated | not extracted yet |
| Kaur 2005 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Kaur 2005 Polymorphism in IGF-2 as a surrogate marker for predisposition towards tobacco chewing-mediated oral cancer. PMID:15970649 | 2005 | this review only | not stated | not extracted yet |
| Kietthubthew 2006 Polymorphism in DNA repair genes and oral squamous cell carcinoma in Thailand. PMID:16373199 | 2006 | this review only | not stated | not extracted yet |
| Kostić 2013 Analysis of polymorphism in the survivin gene promoter as a potential risk factor for head and neck cancers development. PMID:23858797 | 2013 | this review only | not stated | not extracted yet |
| Lacko 2009 Genetic polymorphisms in the tobacco smoke carcinogens detoxifying enzyme UGT1A7 and the risk of head and neck cancer. PMID:19360737 | 2009 | this review only | not stated | not extracted yet |
| Lau 2017 Effect of genetic variation in microRNA binding site in WNT1-inducible signaling pathway protein 1 gene on oral squamous cell carcinoma… PMID:28426731 | 2017 | this review only | not stated | not extracted yet |
| Li 2004 Association of a p73 exon 2 G4C14-to-A4T14 polymorphism with risk of squamous cell carcinoma of the head and neck. PMID:15180941 | 2004 | this review only | not stated | not extracted yet |
| Li 2007 Genetic polymorphisms in DNA base-excision repair genes ADPRT, XRCC1, and APE1 and the risk of squamous cell carcinoma of the head and neck. PMID:17614107 | 2007 | this review only | not stated | not extracted yet |
| Li 2010 The six-nucleotide deletion/insertion variant in the CASP8 promoter region is inversely associated with risk of squamous cell carcinoma of… PMID:20086182 | 2010 | this review only | not stated | not extracted yet |
| Li 2020 The Contribution of Interleukin-12A Genotypes to Oral Cancer Risk in Taiwanese. PMID:32620609 | 2020 | this review only | not stated | not extracted yet |
| Lien 2017 Impact of CCL4 gene polymorphisms and environmental factors on oral cancer development and clinical characteristics. PMID:28404909 | 2017 | this review only | not stated | not extracted yet |
| Lin 2015 Interactions between environmental factors and melatonin receptor type 1A polymorphism in relation to oral cancer susceptibility and… PMID:25806809 | 2015 | this review only | not stated | not extracted yet |
| Liu 2001 Elucidation of CYP2E1 5' regulatory RsaI/Pstl allelic variants and their role in risk for oral cancer. PMID:11377232 | 2001 | this review only | not stated | not extracted yet |
| Liu 2005 Polymorphisms of vitamin D receptor gene protect against the risk of head and neck cancer. PMID:15861040 | 2005 | this review only | not stated | not extracted yet |
| Liu 2010 Genetic variants in selected pre-microRNA genes and the risk of squamous cell carcinoma of the head and neck. PMID:20549817 | 2010 | this review only | not stated | not extracted yet |
| Liu 2022 Genetic variants in CYP2B6 and HSD17B12 associated with risk of squamous cell carcinoma of the head and neck. PMID:35404482 | 2022 | this review only | not stated | not extracted yet |
| Lu 2007 172G>T variant in the 5' untranslated region of DNA repair gene RAD51 reduces risk of squamous cell carcinoma of the head and neck and… PMID:17118968 | 2007 | this review only | not stated | not extracted yet |
| Lu 2009 A novel functional variant (-842G>C) in the PIN1 promoter contributes to decreased risk of squamous cell carcinoma of the head and neck by… PMID:19625347 | 2009 | this review only | not stated | not extracted yet |
| Lu 2014 HLA typing in Taiwanese patients with oral squamous cell carcinoma DOI:10.1016/j.jds.2013.02.005 | 2014 | this review only | not stated | not extracted yet |
| Lu 2022 Role of TNFSF15 variants in oral cancer development and clinicopathologic characteristics. PMID:36226563 | 2022 | this review only | not stated | not extracted yet |
| Majumder 2005 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Majumder 2012 Association between polymorphisms at N-acetyltransferase 1 (NAT1) & risk of oral leukoplakia & cancer. PMID:23168701 | 2012 | this review only | not stated | not extracted yet |
| Malinowska 2016 TC2 C776G polymorphism studies in patients with oral cancer in the Polish population. PMID:28155977 | 2016 | this review only | not stated | not extracted yet |
| Matthias 1998 Influence of tumour necrosis factor microsatellite polymorphisms on susceptibility to head and neck cancer. PMID:9583800 | 1998 | this review only | not stated | not extracted yet |
| Maurya 2015 Gene-environment interactions in determining differences in genetic susceptibility to cancer in subsites of the head and neck. PMID:25399842 | 2015 | this review only | not stated | not extracted yet |
| Miao 2016 MicroRNA-101 polymorphisms and risk of head and neck squamous cell carcinoma in a Chinese population. PMID:26490987 | 2016 | this review only | not stated | not extracted yet |
| Miri-Moghaddam 2016 Methylenetetrahydrofolate reductase C677T and A1298C gene polymorphisms in oral squamous cell carcinoma in south-east Iran. PMID:26218632 | 2016 | this review only | not stated | not extracted yet |
| Murali 2014 Association of single nucleotide polymorphisms in cell cycle regulatory genes with oral cancer susceptibility. PMID:24947332 | 2014 | this review only | not stated | not extracted yet |
| Neumann 2005 Methylenetetrahydrofolate reductase polymorphisms and risk of squamous cell carcinoma of the head and neck: a case-control analysis. PMID:15688408 | 2005 | this review only | not stated | not extracted yet |
| Niu 2009 Genetic polymorphisms in the PTPN13 gene and risk of squamous cell carcinoma of head and neck. PMID:19892796 | 2009 | this review only | not stated | not extracted yet |
| Niu 2014 Association between cyclooxygenase-2 gene polymorphisms and head and neck squamous cell carcinoma risk. PMID:24469360 | 2014 | this review only | not stated | not extracted yet |
| Pandey 2023 Single Nucleotide Polymorphisms in Cytokine Genes are Associated with the Susceptibility to Oral Squamous Cell Carcinoma. PMID:37505766 | 2023 | this review only | not stated | not extracted yet |
| Peters 2005 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Peters 2005 The ADH1C polymorphism modifies the risk of squamous cell carcinoma of the head and neck associated with alcohol and tobacco use. PMID:15734975 | 2005 | this review only | not stated | not extracted yet |
| Peters 2006 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Peters 2006 Glutathione S-transferase polymorphisms and the synergy of alcohol and tobacco in oral, pharyngeal, and laryngeal carcinoma. PMID:17119046 | 2006 | this review only | not stated | not extracted yet |
| Rosa 2021 Revisiting the metallothionein genes polymorphisms and the risk of oral squamous cell carcinoma in a Brazilian population. PMID:33340085 | 2021 | this review only | not stated | not extracted yet |
| Roy 2014 Genetic variations at microRNA and processing genes and risk of oral cancer. PMID:24297336 | 2014 | this review only | not stated | not extracted yet |
| Ruiz 2012 Q36R polymorphism of KiSS-1 gene in Brazilian head and neck cancer patients. PMID:22209985 | 2012 | this review only | not stated | not extracted yet |
| Ruwali 2011 Polymorphism in glutathione S-transferases: susceptibility and treatment outcome for head and neck cancer. PMID:21957883 | 2011 | this review only | not stated | not extracted yet |
| Sailasree 2011 Influence of methylenetetrahydrofolate reductase polymorphisms in oral cancer patients. PMID:20923444 | 2011 | this review only | not stated | not extracted yet |
| Saleem 2013 P53 (Pro72Arg) polymorphism associated with the risk of oral squamous cell carcinoma in gutka, niswar and manpuri addicted patients of… PMID:23683469 | 2013 | this review only | not stated | not extracted yet |
| Santos 2019 Clinicopathological significance of SNPs in RAD51 and XRCC3 in oral and oropharyngeal carcinomas. PMID:30033552 | 2019 | this review only | not stated | not extracted yet |
| Sato 1999 Genetic polymorphism of drug-metabolizing enzymes and susceptibility to oral cancer. PMID:10506106 | 1999 | this review only | not stated | not extracted yet |
| Sharma 2010 Polymorphisms in CYP2A13 and UGT1A7 genes and head and neck cancer susceptibility in North Indians. PMID:20534012 | 2010 | this review only | not stated | not extracted yet |
| Shen 2002 P53 codon 72 polymorphism and risk of squamous cell carcinoma of the head and neck: a case-control study. PMID:12065086 | 2002 | this review only | not stated | not extracted yet |
| Shukla 2012 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Singh 2014 Effects of interleukin-18 promoter (C607A and G137C) gene polymorphisms and their association with oral squamous cell carcinoma (OSCC) in… PMID:25398690 | 2014 | this review only | not stated | not extracted yet |
| Singh 2015 Association of TNF-α (-238 and -308) promoter polymorphisms with susceptibility of oral squamous cell carcinoma in North Indian population. PMID:25519014 | 2015 | this review only | not stated | not extracted yet |
| Singh 2015 Influence of the CYP1A1 T3801C Polymorphism on Tobacco and Alcohol-Associated Head and Neck Cancer Susceptibility in Northeast India. PMID:26514474 | 2015 | this review only | not stated | not extracted yet |
| Singh 2017 Association of -330 interleukin-2 gene polymorphism with oral cancer. PMID:29664031 | 2017 | this review only | not stated | not extracted yet |
| Sreelekha 2001 Genetic polymorphism of CYP1A1, GSTM1 and GSTT1 genes in Indian oral cancer. PMID:11564581 | 2001 | this review only | not stated | not extracted yet |
| Sturgis 2002 DNA repair gene ERCC1 and ERCC2/XPD polymorphisms and risk of squamous cell carcinoma of the head and neck. PMID:12220217 | 2002 | this review only | not stated | not extracted yet |
| Su 2015 Polymorphisms and Plasma Levels of Tissue Inhibitor of Metalloproteinase-3: Impact on Genetic Susceptibility and Clinical Outcome of Oral… PMID:26579821 | 2015 | this review only | not stated | not extracted yet |
| Su 2016 Combinations of FUT2 gene polymorphisms and environmental factors are associated with oral cancer risk. PMID:26646561 | 2016 | this review only | not stated | not extracted yet |
| Su 2018 Associations of genetic variations of the endothelial nitric oxide synthase gene and environmental carcinogens with oral cancer… PMID:29932969 | 2018 | this review only | not stated | not extracted yet |
| Su 2018 PMID:79172018 | NR | this review only | not stated | not extracted yet |
| Sun 2016 The Contribution of Matrix Metalloproteinase-1 Genotype to Oral Cancer Susceptibility in Taiwan. PMID:27381606 | 2016 | this review only | not stated | not extracted yet |
| Sushma 2015 Genetic Variation in MicroRNAs and Risk of Oral Squamous Cell Carcinoma in South Indian Population. PMID:26625766 | 2015 | this review only | not stated | not extracted yet |
| Tamaki 2007 An association between the MICA-A5.1 allele and an increased susceptibility to oral squamous cell carcinoma in Japanese patients. PMID:17559497 | 2007 | this review only | not stated | not extracted yet |
| Tandon 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Tandon 2018 miRNA genetic variants: As potential diagnostic biomarkers for oral cancer. PMID:29103762 | 2018 | this review only | not stated | not extracted yet |
| Teng 2009 Contribution of genetic polymorphisms of stromal cell-derived factor-1 and its receptor, CXCR4, to the susceptibility and… PMID:19373784 | 2009 | this review only | not stated | not extracted yet |
| Tsai 2004 Urokinase gene 3'-UTR T/C polymorphism is associated with oral cancer. PMID:15356878 | 2004 | this review only | not stated | not extracted yet |
| Tsai 2005 Interleukin-4 gene, but not the interleukin-1 beta gene polymorphism, is associated with oral cancer. PMID:15900573 | 2005 | this review only | not stated | not extracted yet |
| Tsai 2013 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Tsai 2013 Impact of interleukin-18 polymorphisms -607A/C and -137G/C on oral cancer occurrence and clinical progression. PMID:24349532 | 2013 | this review only | not stated | not extracted yet |
| Tsai 2014 Contribution of DNA double-strand break repair gene XRCC3 genotypes to oral cancer susceptibility in Taiwan. PMID:24922659 | 2014 | this review only | not stated | not extracted yet |
| Vairaktaris 2007 The 1040C/T polymorphism influencing thermal stability and activity of thrombin activatable fibrinolysis inhibitor is associated with risk… PMID:17636471 | 2007 | this review only | not stated | not extracted yet |
| Vairaktaris 2008 Gene expression polymorphisms of interleukins-1 beta, -4, -6, -8, -10, and tumor necrosis factors-alpha, -beta: regression analysis of… PMID:18273643 | 2008 | this review only | not stated | not extracted yet |
| Wan 2015 Genetic association between PIK3CA gene and oral squamous cell carcinoma: a case control study conducted in Chongqing, China. PMID:26722541 | 2015 | this review only | not stated | not extracted yet |
| Wang 2013 Association of two BRM promoter polymorphisms with head and neck squamous cell carcinoma risk. PMID:23322154 | 2013 | this review only | not stated | not extracted yet |
| Wang 2014 Polymorphisms of microRNA-binding sites in integrin genes are associated with oral squamous cell carcinoma susceptibility and progression. PMID:24769516 | 2014 | this review only | not stated | not extracted yet |
| Wang 2020 Expression and Genetic Polymorphisms of ERCC1 in Chinese Han Patients with Oral Squamous Cell Carcinoma. PMID:33029487 | 2020 | this review only | not stated | not extracted yet |
| Wang 2023 Association of genetic variants of CircCHST15 with oral squamous cell carcinoma in the Chinese Han population. PMID:36608057 | 2023 | this review only | not stated | not extracted yet |
| Wei 2010 A single nucleotide polymorphism in the alcohol dehydrogenase 7 gene (alanine to glycine substitution at amino acid 92) is associated with… PMID:20336794 | 2010 | this review only | not stated | not extracted yet |
| Weng 2012 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Weng 2012 Single nucleotide polymorphisms and haplotypes of MMP-14 are associated with the risk and pathological development of oral cancer. PMID:21512861 | 2012 | this review only | not stated | not extracted yet |
| Werbrouck 2008 Single-nucleotide polymorphisms in DNA double-strand break repair genes: association with head and neck cancer and interaction with… PMID:18768166 | 2008 | this review only | not stated | not extracted yet |
| Wilkins 2017 Genome-scale identification of microRNA-related SNPs associated with risk of head and neck squamous cell carcinoma. PMID:28582492 | 2017 | this review only | not stated | not extracted yet |
| Yang 2016 PTEN gene polymorphisms and susceptibility to oral squamous cell carcinoma in a Chinese Han population. PMID:26232326 | 2016 | this review only | not stated | not extracted yet |
| Yang 2016 Impact of Maspin Polymorphism rs2289520 G/C and Its Interaction with Gene to Gene, Alcohol Consumption Increase Susceptibility to Oral… PMID:27525723 | 2016 | this review only | not stated | not extracted yet |
| Yapijakis 2007 The low VEGF production allele of the +936C/T polymorphism is strongly associated with increased risk for oral cancer. PMID:17564725 | 2007 | this review only | not stated | not extracted yet |
| Yeh 2020 Impact of SRY-Box Transcription Factor 11 Gene Polymorphisms on Oral Cancer Risk and Clinicopathologic Characteristics. PMID:32586027 | 2020 | this review only | not stated | not extracted yet |
| Yeh 2023 Interactive effects of CDKN2B-AS1 gene polymorphism and habitual risk factors on oral cancer. PMID:37724356 | 2023 | this review only | not stated | not extracted yet |
| Yu 2011 Polymorphisms of MDM4 and risk of squamous cell carcinoma of the head and neck. PMID:21540763 | 2011 | this review only | not stated | not extracted yet |
| Yu 2012 Association between single nucleotide polymorphisms in ERCC4 and risk of squamous cell carcinoma of the head and neck. PMID:22848636 | 2012 | this review only | not stated | not extracted yet |
| Yuan 2013 Genetic variants at 10q23 are associated with risk of head and neck cancer in a Chinese population. PMID:23151416 | 2013 | this review only | not stated | not extracted yet |
| Zakiullah 2015 Genetic susceptibility to oral cancer due to combined effects of GSTT1, GSTM1 and CYP1A1 gene variants in tobacco addicted patients of… PMID:25735346 | 2015 | this review only | not stated | not extracted yet |
| Zarate 2017 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Zarate 2017 Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in Argentine patients. PMID:28459200 | 2017 | this review only | not stated | not extracted yet |
| Zeljic 2012 Vitamin D receptor, CYP27B1 and CYP24A1 genes polymorphisms association with oral cancer risk and survival. PMID:22612324 | 2012 | this review only | not stated | not extracted yet |
| Zhang 2005 Polymorphisms and haplotypes of serine hydroxymethyltransferase and risk of squamous cell carcinoma of the head and neck: a case-control… PMID:16006999 | 2005 | this review only | not stated | not extracted yet |
| Zhang 2006 Polymorphisms of FAS and FAS ligand genes involved in the death pathway and risk and progression of squamous cell carcinoma of the head… PMID:17000697 | 2006 | this review only | not stated | not extracted yet |
| Zhang 2010 Polymorphisms of the DNA repair gene MGMT and risk and progression of head and neck cancer. PMID:20206583 | 2010 | this review only | not stated | not extracted yet |
| Zhang 2017 Association between polymorphisms in pre-miRNA genes and risk of oral squamous cell cancer in a Chinese population. PMID:28609461 | 2017 | this review only | not stated | not extracted yet |
| Zinzindohoué 2004 Single nucleotide polymorphisms in MMP1 and MMP3 gene promoters as risk factor in head and neck squamous cell carcinoma. PMID:15274394 | 2004 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients histologically diagnosed with oral squamous cell carcinoma (OSCC), including tobacco-associated OSCC; HPV-associated and recurrent OSCC excluded | OSCC patients in 173 studies meta-analyzed (189 articles extracted); mainly Taiwan, China, India and USA |
| Intervention | Genes or groups of genes (polymorphisms, expression, miRNA) related to susceptibility of OSCC | 28 gene groups in the main random-effects analysis (e.g., miRNA, CYP1A1, NFKB, TNF, GSTM, P53, CASP8); 30 gene groups in habit subgroup analyses |
| Comparison | Controls without OSCC; role of genes compared with environmental risk factors (tobacco, alcohol) | Controls without OSCC |
| Outcomes | Susceptibility (risk) of developing OSCC, odds ratio of association | Pooled OR and Z, I2, p for OSCC susceptibility by gene (Table 2); habit-stratified Z, I2, p (Table 3); family history OR 0.70; chronic mucosal trauma OR 1.38 |
| Study designs | Observational studies (case-control, cross-sectional, cohort) with laboratory gene assessment; Newcastle-Ottawa scale for risk of bias | Case-control and other observational studies (173 meta-analyzed) |
| Timing | Studies published January 2000 to April 2024 | Studies 2000 to 2024 |