Non-Cochrane · aetiology · PM42689117
Systematic evaluation of genetic polymorphisms in carcinogen metabolizing enzymes associated with oral potentially malignant disorders progression to oral cancer risk.
Xu Ziyuan, Zhu Yuhan, Shi Linjun, et al. · Journal of dental sciences · 2026 · PubMed · doi:10.1016/j.jds.2025.12.021
Findings
14 findings
| Population | ||||
|---|---|---|---|---|
| Patients with oral potentially malignant disorders (OPMD) versus patients with oral squamous cell carcinoma (OSCC) | CYP1A1 MspI: TC+CC genotype | CYP1A1 MspI: TT genotype | Genotype frequency in OSCC versus OPMD (OPMD progression to OSCC risk) OLK | OR 1.13 [0.67, 1.88] GRADE not reported 1 study · 884 participants |
| OPMD | CYP1A1 MspI TC+CC genotype | CYP1A1 MspI TT genotype | Oral squamous cell carcinoma versus OPMD Non-specified OPMD | OR 1.45 [0.71, 2.97] GRADE not reported 4 studies · 1269 participants |
| OPMD | CYP1A1 MspI TC+CC genotype | CYP1A1 MspI TT genotype | Oral squamous cell carcinoma versus OPMD Overall | OR 1.38 [0.8, 2.38] GRADE not reported 5 studies · 2153 participants |
| OPMD | GSTM1 null genotype | GSTM1 present genotype | Oral squamous cell carcinoma versus OPMD Non-specified OPMD | OR 1.12 [0.79, 1.59] GRADE not reported 3 studies · 1103 participants |
| OPMD | GSTM1 null genotype | GSTM1 present genotype | Oral squamous cell carcinoma versus OPMD Overall | OR 1.48 [1.08, 2.03] GRADE not reported 11 studies · 3469 participants |
| OPMD | GSTM1 null genotype | GSTM1 present genotype | Oral squamous cell carcinoma versus OPMD Overall; abstract estimate differs from Figure 1B and Results | OR 1.72 [1.24, 2.37] GRADE not reported 11 studies · 3414 participants |
| oral leukoplakia | GSTM1 null genotype | GSTM1 present genotype | Oral squamous cell carcinoma versus OPMD Oral leukoplakia | OR 1.67 [1.03, 2.71] GRADE not reported 8 studies · 2256 participants |
| oral submucous fibrosis | GSTM1 null genotype | GSTM1 present genotype | Oral squamous cell carcinoma versus OPMD Oral submucous fibrosis | OR 2.13 [0.75, 6.01] GRADE not reported 2 studies · 110 participants |
| OPMD | GSTT1 null genotype | GSTT1 present genotype | Oral squamous cell carcinoma versus OPMD Overall | OR 1.14 [0.89, 1.46] GRADE not reported 8 studies · 2869 participants |
| OPMD | GSTT1 null genotype | GSTT1 present genotype | Oral squamous cell carcinoma versus OPMD Non-specified OPMD | OR 1.3 [0.77, 2.19] GRADE not reported 2 studies · 863 participants |
| oral leukoplakia | GSTT1 null genotype | GSTT1 present genotype | Oral squamous cell carcinoma versus OPMD Oral leukoplakia | OR 1.08 [0.8, 1.45] GRADE not reported 6 studies · 1896 participants |
| oral submucous fibrosis | GSTT1 null genotype | GSTT1 present genotype | Oral squamous cell carcinoma versus OPMD Oral submucous fibrosis | OR 1.28 [0.58, 2.82] GRADE not reported 2 studies · 110 participants |
| OPMD | GSTM3 AA genotype | GSTM3 AB+BB genotype | Oral squamous cell carcinoma versus OPMD Overall | OR 0.96 [0.67, 1.37] GRADE not reported 3 studies · 902 participants |
| OPMD | GSTP1 AG+GG genotype | GSTP1 AA genotype | Oral squamous cell carcinoma versus OPMD Overall | OR 0.98 [0.79, 1.21] GRADE not reported 3 studies · 1756 participants |
Included primary studies 21
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Kao et al. 2002 Genetic polymorphism of cytochrome P4501A1 and susceptibility to oral squamous cell carcinoma and oral precancer lesions associated with… PMID:12269988 | 2002 | 1 other review | not stated | not extracted yet |
| Madhulatha 2018 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| Majumder et al. 2005 Increased risk of oral leukoplakia and cancer among mixed tobacco users carrying XRCC1 variant haplotypes and cancer among smokers… PMID:16172217 | 2005 | 1 other review | not stated | not extracted yet |
| Shukla et al. 2012 Genetic polymorphism of drug metabolizing enzymes (GSTM1 and CYP1A1) as risk factors for oral premalignant lesions and oral cancer. PMID:22660220 | 2012 | 1 other review | not stated | not extracted yet |
| Alamgir 2022 Genetic profiles of different ethnicities living in Karachi as regards to tobacco-metabolizing enzyme systems and the risk of oral cancer DOI:10.47391/jpma.3053 | 2022 | this review only | not stated | not extracted yet |
| Alamgir et al. 2022 Genetic profiles of different ethnicities living in Karachi as regards to tobacco-metabolising enzyme systems and the risk of oral cancer. PMID:35751315 | 2022 | this review only | not stated | not extracted yet |
| Anantharaman 2007 Susceptibility to oral cancer by genetic polymorphisms at CYP1A1, GSTM1 and GSTT1 loci among Indians: tobacco exposure as a risk modulator DOI:10.1093/carcin/bgm038 | 2007 | this review only | not stated | not extracted yet |
| Anantharaman 2011 Polymorphisms in tobacco metabolism and DNA repair genes modulate oral precancer and cancer risk DOI:10.1016/j.oraloncology.2011.06.015 | 2011 | this review only | not stated | not extracted yet |
| Anantharaman et al. 2007 Susceptibility to oral cancer by genetic polymorphisms at CYP1A1, GSTM1 and GSTT1 loci among Indians: tobacco exposure as a risk modulator. PMID:17307803 | 2007 | this review only | not stated | not extracted yet |
| Anantharaman et al. 2011 Polymorphisms in tobacco metabolism and DNA repair genes modulate oral precancer and cancer risk. PMID:21741876 | 2011 | this review only | not stated | not extracted yet |
| Bathi 2009 GST null genotype and antioxidants: Risk indicators for oral pre-cancer and cancer DOI:10.4103/0970-9290.57365 | 2009 | this review only | not stated | not extracted yet |
| Bathi et al. 2009 GST null genotype and antioxidants: risk indicators for oral pre-cancer and cancer. PMID:19884712 | 2009 | this review only | not stated | not extracted yet |
| Kao 2002 Genetic polymorphism of cytochrome P4501A1 and susceptibility to oral squamous cell carcinoma and oral precancer lesions associated with… DOI:10.1034/j.1600-0714.2002.00158.x | 2002 | this review only | not stated | not extracted yet |
| Majumder 2005 Increased Risk of Oral Leukoplakia and Cancer Among Mixed Tobacco Users Carrying <i>XRCC1</i> Variant Haplotypes and Cancer Among Smokers… DOI:10.1158/1055-9965.epi-05-0108 | 2005 | this review only | not stated | not extracted yet |
| Rao 2017 Evaluation of Genetic Polymorphisms in Glutathione S-Transferase Theta1, Glutathione S-Transferase Mu1, and Glutathione S-Transferase Mu3… PMID:28904918 | 2017 | this review only | not stated | not extracted yet |
| Shukla 2012 Genetic polymorphism of drug metabolizing enzymes (GSTM1 and CYP1A1) as risk factors for oral premalignant lesions and oral cancer DOI:10.5507/bp.2012.013 | 2012 | this review only | not stated | not extracted yet |
| Sikdar 2004 Glutathione <i>S</i>‐transferase <i>M3</i> (<i>A/A</i>) genotype as a risk factor for oral cancer and leukoplakia among Indian tobacco… DOI:10.1002/ijc.11610 | 2003 | this review only | not stated | not extracted yet |
| Sikdar et al. 2004 Glutathione S-transferase M3 (A/A) genotype as a risk factor for oral cancer and leukoplakia among Indian tobacco smokers. PMID:14735473 | 2004 | this review only | not stated | not extracted yet |
| Tanwar 2015 Prevalence of glutathione S-transferase M1 null polymorphism in tobacco users, oral leukoplakia and oral squamous cell carcinoma patients… PMID:25821378 | 2015 | this review only | not stated | not extracted yet |
| Tanwar 2016 GSTM1 null polymorphism prevalence in tobacco users, oral leukoplakia and oral squamous cell carcinoma patients in South Indian… DOI:10.4103/0970-9290.191881 | 2016 | this review only | not stated | not extracted yet |
| Tanwar et al. 2016 GSTM1 null polymorphism prevalence in tobacco users, oral leukoplakia and oral squamous cell carcinoma patients in South Indian… PMID:27723629 | 2016 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients with OPMD versus OSCC; histologically confirmed | OPMD (n=624 to 1195) versus OSCC (n=1529 to 2274) from India, China, Pakistan |
| Intervention | Polymorphisms in carcinogen metabolizing genes (CYP1A1 MspI, GSTM1, GSTM3, GSTT1, GSTP1) | CYP1A1 MspI (5 studies), GSTM1 (11), GSTT1 (8), GSTM3 (3), GSTP1 (3) |
| Comparison | Reference genotype | Reference genotypes |
| Outcomes | OR of genotype in OSCC versus OPMD (progression risk) | Pooled ORs; only GSTM1 null significant (OR 1.48, 95% CI 1.08-2.03) |
| Study designs | Human case-control studies; genes with at least 3 studies | Case-control studies (n=12) |
| Timing | Not specified | Not specified |