Non-Cochrane · aetiology · PM42700036
A systematic review and network meta-analysis of single nucleotide polymorphisms associated with oral submucous fibrosis risk.
Huang Chunxia, Liu Juan, Zeng Bin, et al. · Medicine · 2026 · PubMed · doi:10.1097/md.0000000000050594
Findings
311 findings
| Population | ||||
|---|---|---|---|---|
| People with oral submucous fibrosis and healthy controls | LOX rs1800449:G>A AA | LOX rs1800449:G>A GG | Oral submucous fibrosis susceptibility Sensitivity analysis: excluding HWE-deviating study | OR 1.10 [0.45, 2.73] GRADE not reported 2 studies |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | LOX rs1800449:G>A AA genotype | LOX rs1800449:G>A GG genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 1.39 [0.68, 2.88] GRADE not reported 3 studies · 695 participants |
| People with oral submucous fibrosis and healthy controls | LOX rs1800449:G>A AA | LOX rs1800449:G>A GG | Oral submucous fibrosis susceptibility | OR 1.39 [0.68, 2.88] GRADE not reported 3 studies · 695 participants |
| People with oral submucous fibrosis and healthy controls | LOX rs1800449:G>A AA | LOX rs1800449:G>A GG | Oral submucous fibrosis susceptibility Sensitivity analysis: random effects | OR 1.40 [0.67, 2.91] GRADE not reported 3 studies · 695 participants |
| People with oral submucous fibrosis and healthy controls | LOX rs1800449:G>A AG | LOX rs1800449:G>A GG | Oral submucous fibrosis susceptibility Sensitivity analysis: fixed effects | OR 1.41 [1.00, 2.00] GRADE not reported 3 studies · 695 participants |
| People with oral submucous fibrosis and healthy controls | LOX rs1800449:G>A AG | LOX rs1800449:G>A GG | Oral submucous fibrosis susceptibility Sensitivity analysis: excluding HWE-deviating study | OR 1.18 [0.49, 2.82] GRADE not reported 2 studies |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | LOX rs1800449:G>A AG genotype | LOX rs1800449:G>A GG genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 1.41 [0.76, 2.61] GRADE not reported 3 studies · 695 participants |
| People with oral submucous fibrosis and healthy controls | LOX rs1800449:G>A AG | LOX rs1800449:G>A GG | Oral submucous fibrosis susceptibility | OR 1.41 [0.76, 2.61] GRADE not reported 3 studies · 695 participants |
| People with oral submucous fibrosis and healthy controls | LOX rs1800449:G>A AA | LOX rs1800449:G>A AG + GG | Oral submucous fibrosis susceptibility | OR 1.22 [0.59, 2.53] GRADE not reported 3 studies · 695 participants |
| People with oral submucous fibrosis and healthy controls | LOX rs1800449:G>A AA | LOX rs1800449:G>A AG + GG | Oral submucous fibrosis susceptibility Sensitivity analysis: excluding HWE-deviating study | OR 1.00 [0.41, 2.45] GRADE not reported 2 studies |
| People with oral submucous fibrosis and healthy controls | LOX rs1800449:G>A AA | LOX rs1800449:G>A AG + GG | Oral submucous fibrosis susceptibility Sensitivity analysis: fixed effects | OR 1.23 [0.60, 2.51] GRADE not reported 3 studies · 695 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | LOX rs1800449:G>A AA genotype | LOX rs1800449:G>A AG + GG genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 1.22 [0.59, 2.53] GRADE not reported 3 studies · 695 participants |
| People with oral submucous fibrosis and healthy controls | LOX rs1800449:G>A AA + AG | LOX rs1800449:G>A GG | Oral submucous fibrosis susceptibility Sensitivity analysis: fixed effects | OR 1.41 [1.01, 1.95] GRADE not reported 3 studies · 695 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | LOX rs1800449:G>A AA + AG genotype | LOX rs1800449:G>A GG genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 1.40 [0.75, 2.58] GRADE not reported 3 studies · 695 participants |
| People with oral submucous fibrosis and healthy controls | LOX rs1800449:G>A AA + AG | LOX rs1800449:G>A GG | Oral submucous fibrosis susceptibility | OR 1.40 [0.75, 2.58] GRADE not reported 3 studies · 695 participants |
| People with oral submucous fibrosis and healthy controls | LOX rs1800449:G>A AA + AG | LOX rs1800449:G>A GG | Oral submucous fibrosis susceptibility Sensitivity analysis: excluding HWE-deviating study | OR 1.15 [0.49, 2.72] GRADE not reported 2 studies |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | LOX rs1800449:G>A A allele | LOX rs1800449:G>A G allele | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 1.30 [0.79, 2.16] GRADE not reported 3 studies · 695 participants |
| People with oral submucous fibrosis and healthy controls | LOX rs1800449:G>A A | LOX rs1800449:G>A G | Oral submucous fibrosis susceptibility Sensitivity analysis: excluding HWE-deviating study | OR 1.10 [0.56, 2.14] GRADE not reported 2 studies |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | LOX rs1800449:G>A A allele | LOX rs1800449:G>A G allele | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 1.32 [1.00, 1.74] GRADE not reported 3 studies · 695 participants |
| People with oral submucous fibrosis and healthy controls | LOX rs1800449:G>A A | LOX rs1800449:G>A G | Oral submucous fibrosis susceptibility | OR 1.30 [0.79, 2.16] GRADE not reported 3 studies · 695 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C CC genotype | CYP1A1 rs4646903:T>C TT genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 4.35 [2.41, 7.86] GRADE not reported 2 studies · 527 participants |
| People with oral submucous fibrosis and healthy controls | CYP1A1 rs4646903:T>C CC | CYP1A1 rs4646903:T>C TT | Oral submucous fibrosis susceptibility Sensitivity analysis: random effects | OR 4.28 [2.36, 7.76] GRADE not reported 2 studies · 527 participants |
| People with oral submucous fibrosis and healthy controls | CYP1A1 rs4646903:T>C CC | CYP1A1 rs4646903:T>C TT | Oral submucous fibrosis susceptibility | OR 4.35 [2.41, 7.86] GRADE not reported 2 studies · 527 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C CT genotype | CYP1A1 rs4646903:T>C TT genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 2.08 [1.06, 4.08] GRADE not reported 2 studies · 527 participants |
| People with oral submucous fibrosis and healthy controls | CYP1A1 rs4646903:T>C CT | CYP1A1 rs4646903:T>C TT | Oral submucous fibrosis susceptibility Sensitivity analysis: fixed effects | OR 2.12 [1.35, 3.35] GRADE not reported 2 studies · 527 participants |
| People with oral submucous fibrosis and healthy controls | CYP1A1 rs4646903:T>C CT | CYP1A1 rs4646903:T>C TT | Oral submucous fibrosis susceptibility | OR 2.08 [1.06, 4.08] GRADE not reported 2 studies · 527 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C CC genotype | CYP1A1 rs4646903:T>C CT + TT genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 3.27 [2.07, 5.17] GRADE not reported 2 studies · 527 participants |
| People with oral submucous fibrosis and healthy controls | CYP1A1 rs4646903:T>C CC | CYP1A1 rs4646903:T>C CT + TT | Oral submucous fibrosis susceptibility Sensitivity analysis: random effects | OR 3.05 [1.59, 5.83] GRADE not reported 2 studies · 527 participants |
| People with oral submucous fibrosis and healthy controls | CYP1A1 rs4646903:T>C CC | CYP1A1 rs4646903:T>C CT + TT | Oral submucous fibrosis susceptibility | OR 3.27 [2.07, 5.17] GRADE not reported 2 studies · 527 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C CC + CT genotype | CYP1A1 rs4646903:T>C TT genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 2.65 [1.72, 4.09] GRADE not reported 2 studies · 527 participants |
| People with oral submucous fibrosis and healthy controls | CYP1A1 rs4646903:T>C CC + CT | CYP1A1 rs4646903:T>C TT | Oral submucous fibrosis susceptibility Sensitivity analysis: random effects | OR 2.67 [1.73, 4.10] GRADE not reported 2 studies · 527 participants |
| People with oral submucous fibrosis and healthy controls | CYP1A1 rs4646903:T>C CC + CT | CYP1A1 rs4646903:T>C TT | Oral submucous fibrosis susceptibility | OR 2.65 [1.72, 4.09] GRADE not reported 2 studies · 527 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C C allele | CYP1A1 rs4646903:T>C T allele | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 2.26 [1.72, 2.96] GRADE not reported 2 studies · 527 participants |
| People with oral submucous fibrosis and healthy controls | CYP1A1 rs4646903:T>C C | CYP1A1 rs4646903:T>C T | Oral submucous fibrosis susceptibility | OR 2.26 [1.73, 2.97] GRADE not reported 2 studies · 527 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C C allele | CYP1A1 rs4646903:T>C T allele | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 2.26 [1.73, 2.97] GRADE not reported 2 studies · 527 participants |
| People with oral submucous fibrosis and healthy controls | CYP1A1 rs1048943:A>G GG | CYP1A1 rs1048943:A>G AA | Oral submucous fibrosis susceptibility Sensitivity analysis: excluding HWE-deviating study | OR 9.67 [5.69, 16.41] GRADE not reported 2 studies |
| People with oral submucous fibrosis and healthy controls | CYP1A1 rs1048943:A>G GG | CYP1A1 rs1048943:A>G AA | Oral submucous fibrosis susceptibility | OR 5.87 [2.16, 15.97] GRADE not reported 3 studies · 702 participants |
| People with oral submucous fibrosis and healthy controls | CYP1A1 rs1048943:A>G GG | CYP1A1 rs1048943:A>G AA | Oral submucous fibrosis susceptibility Sensitivity analysis: fixed effects | OR 5.52 [3.72, 8.19] GRADE not reported 3 studies · 702 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs1048943:A>G GG genotype | CYP1A1 rs1048943:A>G AA genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 5.87 [2.16, 15.97] GRADE not reported 3 studies · 702 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs1048943:A>G GA genotype | CYP1A1 rs1048943:A>G AA genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: excluding HWE-deviating study (Yaming P, 2016) | OR 6.19 [2.32, 16.50] GRADE not reported 2 studies · 527 participants |
| People with oral submucous fibrosis and healthy controls | CYP1A1 rs1048943:A>G GA | CYP1A1 rs1048943:A>G AA | Oral submucous fibrosis susceptibility | OR 6.19 [2.32, 16.50] GRADE not reported 3 studies · 702 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs1048943:A>G GA genotype | CYP1A1 rs1048943:A>G AA genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 6.19 [2.32, 16.50] GRADE not reported 3 studies · 702 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs1048943:A>G GA genotype | CYP1A1 rs1048943:A>G AA genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 6.19 [2.32, 16.50] GRADE not reported 3 studies · 702 participants |
| People with oral submucous fibrosis and healthy controls | CYP1A1 rs1048943:A>G GG | CYP1A1 rs1048943:A>G GA + AA | Oral submucous fibrosis susceptibility Sensitivity analysis: excluding HWE-deviating study | OR 5.65 [2.84, 11.25] GRADE not reported 2 studies |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs1048943:A>G GG genotype | CYP1A1 rs1048943:A>G GA + AA genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 4.23 [2.14, 8.37] GRADE not reported 3 studies · 702 participants |
| People with oral submucous fibrosis and healthy controls | CYP1A1 rs1048943:A>G GG | CYP1A1 rs1048943:A>G GA + AA | Oral submucous fibrosis susceptibility Sensitivity analysis: fixed effects | OR 4.13 [2.94, 5.81] GRADE not reported 3 studies · 702 participants |
| People with oral submucous fibrosis and healthy controls | CYP1A1 rs1048943:A>G GG | CYP1A1 rs1048943:A>G GA + AA | Oral submucous fibrosis susceptibility | OR 4.23 [2.14, 8.37] GRADE not reported 3 studies · 702 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs1048943:A>G GG + GA genotype | CYP1A1 rs1048943:A>G AA genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 5.55 [2.16, 14.25] GRADE not reported 3 studies · 702 participants |
| People with oral submucous fibrosis and healthy controls | CYP1A1 rs1048943:A>G GG + GA | CYP1A1 rs1048943:A>G AA | Oral submucous fibrosis susceptibility | OR 5.55 [2.16, 14.25] GRADE not reported 3 studies · 702 participants |
| People with oral submucous fibrosis and healthy controls | CYP1A1 rs1048943:A>G GG + GA | CYP1A1 rs1048943:A>G AA | Oral submucous fibrosis susceptibility Sensitivity analysis: fixed effects | OR 5.34 [3.60, 7.93] GRADE not reported 3 studies · 702 participants |
| People with oral submucous fibrosis and healthy controls | CYP1A1 rs1048943:A>G GG + GA | CYP1A1 rs1048943:A>G AA | Oral submucous fibrosis susceptibility Sensitivity analysis: excluding HWE-deviating study | OR 8.96 [5.26, 15.26] GRADE not reported 2 studies |
| People with oral submucous fibrosis and healthy controls | CYP1A1 rs1048943:A>G G | CYP1A1 rs1048943:A>G A | Oral submucous fibrosis susceptibility Sensitivity analysis: fixed effects | OR 4.46 [3.46, 5.74] GRADE not reported 3 studies · 702 participants |
| People with oral submucous fibrosis and healthy controls | CYP1A1 rs1048943:A>G G | CYP1A1 rs1048943:A>G A | Oral submucous fibrosis susceptibility Sensitivity analysis: excluding HWE-deviating study | OR 6.33 [3.81, 10.50] GRADE not reported 2 studies |
| People with oral submucous fibrosis and healthy controls | CYP1A1 rs1048943:A>G G | CYP1A1 rs1048943:A>G A | Oral submucous fibrosis susceptibility | OR 4.52 [2.21, 9.26] GRADE not reported 3 studies · 702 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs1048943:A>G G allele | CYP1A1 rs1048943:A>G A allele | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 4.52 [2.21, 9.26] GRADE not reported 3 studies · 702 participants |
| People with oral submucous fibrosis and healthy controls | GSTT1 null genotype Null genotype (-/-) | GSTT1 null genotype Active genotype (+/+ and +/-) | Oral submucous fibrosis susceptibility | OR 2.47 [1.69, 3.59] GRADE not reported 4 studies · 787 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | GSTT1 null genotype Null genotype (-/-) | GSTT1 null genotype Active genotype (+/+ and +/-) | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 2.47 [1.69, 3.59] GRADE not reported 4 studies · 787 participants |
| People with oral submucous fibrosis and healthy controls | GSTT1 null genotype Null genotype (-/-) | GSTT1 null genotype Active genotype (+/+ and +/-) | Oral submucous fibrosis susceptibility Sensitivity analysis: random effects | OR 2.48 [1.70, 3.61] GRADE not reported 4 studies · 787 participants |
| People with oral submucous fibrosis and healthy controls | GSTM1 null genotype Null genotype (-/-) | GSTM1 null genotype Active genotype (+/+ and +/-) | Oral submucous fibrosis susceptibility Sensitivity analysis: random effects | OR 1.79 [1.28, 2.51] GRADE not reported 4 studies · 787 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | GSTM1 null genotype Null genotype (-/-) | GSTM1 null genotype Active genotype (+/+ and +/-) | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 1.81 [1.35, 2.43] GRADE not reported 4 studies · 787 participants |
| People with oral submucous fibrosis and healthy controls | GSTM1 null genotype Null genotype (-/-) | GSTM1 null genotype Active genotype (+/+ and +/-) | Oral submucous fibrosis susceptibility | OR 1.81 [1.35, 2.43] GRADE not reported 4 studies · 787 participants |
| People with oral submucous fibrosis and healthy controls | MMP1 rs1799750:1G > 2G 2G2G | MMP1 rs1799750:1G > 2G 1G1G | Oral submucous fibrosis susceptibility | OR 1.22 [0.47, 3.18] GRADE not reported 2 studies · 1043 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP1 rs1799750:1G>2G 2G2G genotype | MMP1 rs1799750:1G>2G 1G1G genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 1.22 [0.47, 3.18] GRADE not reported 2 studies · 1043 participants |
| People with oral submucous fibrosis and healthy controls | MMP1 rs1799750:1G > 2G 2G2G | MMP1 rs1799750:1G > 2G 1G1G | Oral submucous fibrosis susceptibility Sensitivity analysis: fixed effects | OR 1.48 [0.96, 2.27] GRADE not reported 2 studies · 1043 participants |
| People with oral submucous fibrosis and healthy controls | MMP1 rs1799750:1G > 2G 2G1G | MMP1 rs1799750:1G > 2G 1G1G | Oral submucous fibrosis susceptibility | OR 0.96 [0.74, 1.25] GRADE not reported 2 studies · 1043 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP1 rs1799750:1G>2G 2G1G genotype | MMP1 rs1799750:1G>2G 1G1G genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 0.96 [0.74, 1.25] GRADE not reported 2 studies · 1043 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP1 rs1799750:1G>2G 2G1G genotype | MMP1 rs1799750:1G>2G 1G1G genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 0.96 [0.74, 1.25] GRADE not reported 2 studies · 1043 participants |
| People with oral submucous fibrosis and healthy controls | MMP1 rs1799750:1G > 2G 2G2G | MMP1 rs1799750:1G > 2G 2G1G + 1G1G | Oral submucous fibrosis susceptibility Sensitivity analysis: fixed effects | OR 1.50 [1.00, 2.25] GRADE not reported 2 studies · 1043 participants |
| People with oral submucous fibrosis and healthy controls | MMP1 rs1799750:1G > 2G 2G2G | MMP1 rs1799750:1G > 2G 2G1G + 1G1G | Oral submucous fibrosis susceptibility | OR 1.24 [0.48, 3.18] GRADE not reported 2 studies · 1043 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP1 rs1799750:1G>2G 2G2G genotype | MMP1 rs1799750:1G>2G 2G1G + 1G1G genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 1.24 [0.48, 3.18] GRADE not reported 2 studies · 1043 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP1 rs1799750:1G>2G 2G2G + 2G1G genotype | MMP1 rs1799750:1G>2G 1G1G genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 1.04 [0.81, 1.34] GRADE not reported 2 studies · 1043 participants |
| People with oral submucous fibrosis and healthy controls | MMP1 rs1799750:1G > 2G 2G2G + 2G1G | MMP1 rs1799750:1G > 2G 1G1G | Oral submucous fibrosis susceptibility | OR 1.04 [0.81, 1.34] GRADE not reported 2 studies · 1043 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP1 rs1799750:1G>2G 2G2G + 2G1G genotype | MMP1 rs1799750:1G>2G 1G1G genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 1.04 [0.81, 1.34] GRADE not reported 2 studies · 1043 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP1 rs1799750:1G>2G 2G genotype | MMP1 rs1799750:1G>2G 1G genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 1.12 [0.93, 1.35] GRADE not reported 2 studies · 1043 participants |
| People with oral submucous fibrosis and healthy controls | MMP1 rs1799750:1G > 2G 2G | MMP1 rs1799750:1G > 2G 1G | Oral submucous fibrosis susceptibility | OR 1.12 [0.93, 1.35] GRADE not reported 2 studies · 1043 participants |
| People with oral submucous fibrosis and healthy controls | MMP1 rs1799750:1G > 2G 2G | MMP1 rs1799750:1G > 2G 1G | Oral submucous fibrosis susceptibility Sensitivity analysis: random effects | OR 1.06 [0.77, 1.46] GRADE not reported 2 studies · 1043 participants |
| People with oral submucous fibrosis and healthy controls | MMP2 rs243865:C>T TT | MMP2 rs243865:C>T CC | Oral submucous fibrosis susceptibility Sensitivity analysis: random effects | OR 0.72 [0.28, 1.90] GRADE not reported 2 studies · 1039 participants |
| People with oral submucous fibrosis and healthy controls | MMP2 rs243865:C>T TT | MMP2 rs243865:C>T CC | Oral submucous fibrosis susceptibility | OR 0.74 [0.40, 1.39] GRADE not reported 2 studies · 1039 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP2 rs243865:C>T TT genotype | MMP2 rs243865:C>T CC genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 0.74 [0.40, 1.39] GRADE not reported 2 studies · 1039 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP2 rs243865:C>T TC genotype | MMP2 rs243865:C>T CC genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 0.98 [0.51, 1.91] GRADE not reported 2 studies · 1039 participants |
| People with oral submucous fibrosis and healthy controls | MMP2 rs243865:C>T TC | MMP2 rs243865:C>T CC | Oral submucous fibrosis susceptibility Sensitivity analysis: random effects | OR 0.74 [0.34, 1.58] GRADE not reported 2 studies · 1039 participants |
| People with oral submucous fibrosis and healthy controls | MMP2 rs243865:C>T TC | MMP2 rs243865:C>T CC | Oral submucous fibrosis susceptibility | OR 0.98 [0.51, 1.91] GRADE not reported 2 studies · 1039 participants |
| People with oral submucous fibrosis and healthy controls | MMP2 rs243865:C>T TT | MMP2 rs243865:C>T TC + CC | Oral submucous fibrosis susceptibility Sensitivity analysis: random effects | OR 0.77 [0.29, 2.07] GRADE not reported 2 studies · 1039 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP2 rs243865:C>T TT genotype | MMP2 rs243865:C>T TC + CC genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 0.80 [0.43, 1.49] GRADE not reported 2 studies · 1039 participants |
| People with oral submucous fibrosis and healthy controls | MMP2 rs243865:C>T TT | MMP2 rs243865:C>T TC + CC | Oral submucous fibrosis susceptibility | OR 0.80 [0.43, 1.49] GRADE not reported 2 studies · 1039 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP2 rs243865:C>T TT + TC genotype | MMP2 rs243865:C>T CC genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 0.73 [0.55, 0.97] GRADE not reported 2 studies · 1039 participants |
| People with oral submucous fibrosis and healthy controls | MMP2 rs243865:C>T TT + TC | MMP2 rs243865:C>T CC | Oral submucous fibrosis susceptibility | OR 0.73 [0.55, 0.97] GRADE not reported 2 studies · 1039 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP2 rs243865:C>T TT + TC genotype | MMP2 rs243865:C>T CC genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 0.73 [0.55, 0.97] GRADE not reported 2 studies · 1039 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP2 rs243865:C>T T allele | MMP2 rs243865:C>T C allele | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 0.76 [0.59, 0.97] GRADE not reported 2 studies · 1039 participants |
| People with oral submucous fibrosis and healthy controls | MMP2 rs243865:C>T T | MMP2 rs243865:C>T C | Oral submucous fibrosis susceptibility | OR 0.76 [0.59, 0.97] GRADE not reported 2 studies · 1039 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP2 rs243865:C>T T allele | MMP2 rs243865:C>T C allele | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 0.76 [0.59, 0.98] GRADE not reported 2 studies · 1039 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP3 rs3025058:5A>6A 6A6A genotype | MMP3 rs3025058:5A>6A 5A5A genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 0.49 [0.11, 2.22] GRADE not reported 2 studies · 395 participants |
| People with oral submucous fibrosis and healthy controls | MMP3 rs3025058:5A > 6A 6A6A | MMP3 rs3025058:5A > 6A 5A5A | Oral submucous fibrosis susceptibility | OR 0.49 [0.11, 2.21] GRADE not reported 2 studies · 395 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP3 rs3025058:5A>6A 6A6A genotype | MMP3 rs3025058:5A>6A 5A5A genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 0.49 [0.11, 2.21] GRADE not reported 2 studies · 395 participants |
| People with oral submucous fibrosis and healthy controls | MMP3 rs3025058:5A > 6A 6A5A | MMP3 rs3025058:5A > 6A 5A5A | Oral submucous fibrosis susceptibility | OR 1.26 [0.26, 6.15] GRADE not reported 2 studies · 395 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP3 rs3025058:5A>6A 6A5A genotype | MMP3 rs3025058:5A>6A 5A5A genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 1.26 [0.26, 6.15] GRADE not reported 2 studies · 395 participants |
| People with oral submucous fibrosis and healthy controls | MMP3 rs3025058:5A > 6A 6A5A | MMP3 rs3025058:5A > 6A 5A5A | Oral submucous fibrosis susceptibility Sensitivity analysis: random effects | OR 1.26 [0.26, 6.18] GRADE not reported 2 studies · 395 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP3 rs3025058:5A>6A 6A6A genotype | MMP3 rs3025058:5A>6A 6A5A + 5A5A genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 0.39 [0.23, 0.66] GRADE not reported 2 studies · 395 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP3 rs3025058:5A>6A 6A6A genotype | MMP3 rs3025058:5A>6A 6A5A + 5A5A genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 0.39 [0.23, 0.66] GRADE not reported 2 studies · 395 participants |
| People with oral submucous fibrosis and healthy controls | MMP3 rs3025058:5A > 6A 6A6A | MMP3 rs3025058:5A > 6A 6A5A + 5A5A | Oral submucous fibrosis susceptibility | OR 0.39 [0.23, 0.66] GRADE not reported 2 studies · 395 participants |
| People with oral submucous fibrosis and healthy controls | MMP3 rs3025058:5A > 6A 6A6A + 6A5A | MMP3 rs3025058:5A > 6A 5A5A | Oral submucous fibrosis susceptibility | OR 0.57 [0.13, 2.61] GRADE not reported 2 studies · 395 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP3 rs3025058:5A>6A 6A6A + 6A5A genotype | MMP3 rs3025058:5A>6A 5A5A genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 0.57 [0.13, 2.61] GRADE not reported 2 studies · 395 participants |
| People with oral submucous fibrosis and healthy controls | MMP3 rs3025058:5A > 6A 6A6A + 6A5A | MMP3 rs3025058:5A > 6A 5A5A | Oral submucous fibrosis susceptibility Sensitivity analysis: random effects | OR 0.58 [0.13, 2.63] GRADE not reported 2 studies · 395 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP3 rs3025058:5A>6A 6A genotype | MMP3 rs3025058:5A>6A 5A genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 0.44 [0.28, 0.70] GRADE not reported 2 studies · 395 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP3 rs3025058:5A>6A 6A genotype | MMP3 rs3025058:5A>6A 5A genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 0.44 [0.28, 0.70] GRADE not reported 2 studies · 395 participants |
| People with oral submucous fibrosis and healthy controls | MMP3 rs3025058:5A > 6A 6A | MMP3 rs3025058:5A > 6A 5A | Oral submucous fibrosis susceptibility | OR 0.44 [0.28, 0.70] GRADE not reported 2 studies · 395 participants |
| People with oral submucous fibrosis and healthy controls | MMP9 rs3918242:C>T TT | MMP9 rs3918242:C>T CC | Oral submucous fibrosis susceptibility | OR 1.35 [0.48, 3.77] GRADE not reported 3 studies · 1483 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP9 rs3918242:C>T TT genotype | MMP9 rs3918242:C>T CC genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 1.56 [0.92, 2.67] GRADE not reported 3 studies · 1483 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP9 rs3918242:C>T TT genotype | MMP9 rs3918242:C>T CC genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 1.35 [0.48, 3.77] GRADE not reported 3 studies · 1483 participants |
| People with oral submucous fibrosis and healthy controls | MMP9 rs3918242:C>T TC | MMP9 rs3918242:C>T CC | Oral submucous fibrosis susceptibility | OR 0.93 [0.72, 1.19] GRADE not reported 3 studies · 1483 participants |
| People with oral submucous fibrosis and healthy controls | MMP9 rs3918242:C>T TC | MMP9 rs3918242:C>T CC | Oral submucous fibrosis susceptibility Sensitivity analysis: random effects | OR 1.03 [0.76, 1.40] GRADE not reported 3 studies · 1483 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP9 rs3918242:C>T TC genotype | MMP9 rs3918242:C>T CC genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 0.93 [0.72, 1.19] GRADE not reported 3 studies · 1483 participants |
| People with oral submucous fibrosis and healthy controls | MMP9 rs3918242:C>T TT | MMP9 rs3918242:C>T TC + CC | Oral submucous fibrosis susceptibility | OR 1.32 [0.44, 4.00] GRADE not reported 3 studies · 1483 participants |
| People with oral submucous fibrosis and healthy controls | MMP9 rs3918242:C>T TT | MMP9 rs3918242:C>T TC + CC | Oral submucous fibrosis susceptibility Sensitivity analysis: fixed effects | OR 1.57 [0.93, 2.67] GRADE not reported 3 studies · 1483 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP9 rs3918242:C>T TT genotype | MMP9 rs3918242:C>T TC + CC genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 1.32 [0.44, 4.00] GRADE not reported 3 studies · 1483 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP9 rs3918242:C>T TT + TC genotype | MMP9 rs3918242:C>T CC genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 1.08 [0.85, 1.36] GRADE not reported 3 studies · 1483 participants |
| People with oral submucous fibrosis and healthy controls | MMP9 rs3918242:C>T TT + TC | MMP9 rs3918242:C>T CC | Oral submucous fibrosis susceptibility | OR 1.07 [0.85, 1.36] GRADE not reported 3 studies · 1483 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP9 rs3918242:C>T TT + TC genotype | MMP9 rs3918242:C>T CC genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 1.07 [0.85, 1.36] GRADE not reported 3 studies · 1483 participants |
| People with oral submucous fibrosis and healthy controls | MMP9 rs3918242:C>T T | MMP9 rs3918242:C>T C | Oral submucous fibrosis susceptibility | OR 1.13 [0.92, 1.38] GRADE not reported 3 studies · 1483 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP9 rs3918242:C>T T allele | MMP9 rs3918242:C>T C allele | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 1.13 [0.92, 1.38] GRADE not reported 3 studies · 1483 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP9 rs3918242:C>T T allele | MMP9 rs3918242:C>T C allele | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 1.13 [0.92, 1.38] GRADE not reported 3 studies · 1483 participants |
| People with oral submucous fibrosis and healthy controls | MMP9 rs17576:G>A AA | MMP9 rs17576:G>A GG | Oral submucous fibrosis susceptibility Sensitivity analysis: fixed effects | OR 1.56 [0.86, 2.83] GRADE not reported 2 studies · 465 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP9 rs17576:G>A AA genotype | MMP9 rs17576:G>A GG genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 1.23 [0.34, 4.41] GRADE not reported 2 studies · 465 participants |
| People with oral submucous fibrosis and healthy controls | MMP9 rs17576:G>A AA | MMP9 rs17576:G>A GG | Oral submucous fibrosis susceptibility | OR 1.23 [0.34, 4.41] GRADE not reported 2 studies · 465 participants |
| People with oral submucous fibrosis and healthy controls | MMP9 rs17576:G>A AG | MMP9 rs17576:G>A GG | Oral submucous fibrosis susceptibility | OR 1.12 [0.54, 2.35] GRADE not reported 2 studies · 465 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP9 rs17576:G>A AG genotype | MMP9 rs17576:G>A GG genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 1.12 [0.54, 2.35] GRADE not reported 2 studies · 465 participants |
| People with oral submucous fibrosis and healthy controls | MMP9 rs17576:G>A AG | MMP9 rs17576:G>A GG | Oral submucous fibrosis susceptibility Sensitivity analysis: fixed effects | OR 1.29 [0.87, 1.92] GRADE not reported 2 studies · 465 participants |
| People with oral submucous fibrosis and healthy controls | MMP9 rs17576:G>A AA | MMP9 rs17576:G>A AG + GG | Oral submucous fibrosis susceptibility Sensitivity analysis: random effects | OR 1.29 [0.54, 3.11] GRADE not reported 2 studies · 465 participants |
| People with oral submucous fibrosis and healthy controls | MMP9 rs17576:G>A AA | MMP9 rs17576:G>A AG + GG | Oral submucous fibrosis susceptibility | OR 1.43 [0.81, 2.52] GRADE not reported 2 studies · 465 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP9 rs17576:G>A AA genotype | MMP9 rs17576:G>A AG + GG genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 1.43 [0.81, 2.52] GRADE not reported 2 studies · 465 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP9 rs17576:G>A AA + AG genotype | MMP9 rs17576:G>A GG genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 1.11 [0.46, 2.69] GRADE not reported 2 studies · 465 participants |
| People with oral submucous fibrosis and healthy controls | MMP9 rs17576:G>A AA + AG | MMP9 rs17576:G>A GG | Oral submucous fibrosis susceptibility Sensitivity analysis: fixed effects | OR 1.38 [0.95, 1.99] GRADE not reported 2 studies · 465 participants |
| People with oral submucous fibrosis and healthy controls | MMP9 rs17576:G>A AA + AG | MMP9 rs17576:G>A GG | Oral submucous fibrosis susceptibility | OR 1.11 [0.46, 2.69] GRADE not reported 2 studies · 465 participants |
| People with oral submucous fibrosis and healthy controls | MMP9 rs17576:G>A G | MMP9 rs17576:G>A A | Oral submucous fibrosis susceptibility Sensitivity analysis: fixed effects | OR 1.32 [0.99, 1.75] GRADE not reported 2 studies · 465 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | MMP9 rs17576:G>A G allele | MMP9 rs17576:G>A A allele | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 1.12 [0.55, 2.28] GRADE not reported 2 studies · 465 participants |
| People with oral submucous fibrosis and healthy controls | MMP9 rs17576:G>A G | MMP9 rs17576:G>A A | Oral submucous fibrosis susceptibility | OR 1.12 [0.55, 2.28] GRADE not reported 2 studies · 465 participants |
| People with oral submucous fibrosis and healthy controls | XRCC3 rs861539:C>T TT | XRCC3 rs861539:C>T CC | Oral submucous fibrosis susceptibility | OR 6.86 [2.63, 17.88] GRADE not reported 2 studies · 556 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | XRCC3 rs861539:C>T TT genotype | XRCC3 rs861539:C>T CC genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 6.86 [2.63, 17.88] GRADE not reported 2 studies · 556 participants |
| People with oral submucous fibrosis and healthy controls | XRCC3 rs861539:C>T TT | XRCC3 rs861539:C>T CC | Oral submucous fibrosis susceptibility Sensitivity analysis: random effects | OR 6.98 [1.94, 25.12] GRADE not reported 2 studies · 556 participants |
| People with oral submucous fibrosis and healthy controls | XRCC3 rs861539:C>T TC | XRCC3 rs861539:C>T CC | Oral submucous fibrosis susceptibility Sensitivity analysis: fixed effects | OR 1.25 [0.83, 1.89] GRADE not reported 2 studies · 556 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | XRCC3 rs861539:C>T TC genotype | XRCC3 rs861539:C>T CC genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 1.35 [0.62, 2.93] GRADE not reported 2 studies · 556 participants |
| People with oral submucous fibrosis and healthy controls | XRCC3 rs861539:C>T TC | XRCC3 rs861539:C>T CC | Oral submucous fibrosis susceptibility | OR 1.35 [0.62, 2.93] GRADE not reported 2 studies · 556 participants |
| People with oral submucous fibrosis and healthy controls | XRCC3 rs861539:C>T TT | XRCC3 rs861539:C>T TC + CC | Oral submucous fibrosis susceptibility Sensitivity analysis: fixed effects | OR 6.14 [2.38, 15.83] GRADE not reported 2 studies · 556 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | XRCC3 rs861539:C>T TT genotype | XRCC3 rs861539:C>T TC + CC genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 6.29 [1.35, 29.34] GRADE not reported 2 studies · 556 participants |
| People with oral submucous fibrosis and healthy controls | XRCC3 rs861539:C>T TT | XRCC3 rs861539:C>T TC + CC | Oral submucous fibrosis susceptibility | OR 6.29 [1.35, 29.34] GRADE not reported 2 studies · 556 participants |
| People with oral submucous fibrosis and healthy controls | XRCC3 rs861539:C>T TT + TC | XRCC3 rs861539:C>T CC | Oral submucous fibrosis susceptibility | OR 1.60 [0.87, 2.93] GRADE not reported 2 studies · 556 participants |
| People with oral submucous fibrosis and healthy controls | XRCC3 rs861539:C>T TT + TC | XRCC3 rs861539:C>T CC | Oral submucous fibrosis susceptibility Sensitivity analysis: fixed effects | OR 1.53 [1.04, 2.25] GRADE not reported 2 studies · 556 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | XRCC3 rs861539:C>T TT + TC genotype | XRCC3 rs861539:C>T CC genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 1.60 [0.87, 2.93] GRADE not reported 2 studies · 556 participants |
| People with oral submucous fibrosis and healthy controls | XRCC3 rs861539:C>T T | XRCC3 rs861539:C>T C | Oral submucous fibrosis susceptibility Sensitivity analysis: random effects | OR 1.71 [1.23, 2.36] GRADE not reported 2 studies · 556 participants |
| People with oral submucous fibrosis and healthy controls | XRCC3 rs861539:C>T T | XRCC3 rs861539:C>T C | Oral submucous fibrosis susceptibility | OR 1.71 [1.25, 2.33] GRADE not reported 2 studies · 556 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | XRCC3 rs861539:C>T T allele | XRCC3 rs861539:C>T C allele | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 1.71 [1.25, 2.33] GRADE not reported 2 studies · 556 participants |
| People with oral submucous fibrosis and healthy controls | TP53 rs1042522:G>C CC | TP53 rs1042522:G>C GG | Oral submucous fibrosis susceptibility | OR 1.10 [0.61, 2.01] GRADE not reported 3 studies · 506 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | TP53 rs1042522:G>C CC genotype | TP53 rs1042522:G>C GG genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 1.10 [0.61, 2.01] GRADE not reported 3 studies · 506 participants |
| People with oral submucous fibrosis and healthy controls | TP53 rs1042522:G>C CC | TP53 rs1042522:G>C GG | Oral submucous fibrosis susceptibility Sensitivity analysis: random effects | OR 1.10 [0.60, 2.03] GRADE not reported 3 studies · 506 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | TP53 rs1042522:G>C GC genotype | TP53 rs1042522:G>C GG genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 0.83 [0.52, 1.32] GRADE not reported 3 studies · 506 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | TP53 rs1042522:G>C GC genotype | TP53 rs1042522:G>C GG genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 0.83 [0.52, 1.32] GRADE not reported 3 studies · 506 participants |
| People with oral submucous fibrosis and healthy controls | TP53 rs1042522:G>C GC | TP53 rs1042522:G>C GG | Oral submucous fibrosis susceptibility | OR 0.83 [0.52, 1.32] GRADE not reported 3 studies · 506 participants |
| People with oral submucous fibrosis and healthy controls | TP53 rs1042522:G>C CC | TP53 rs1042522:G>C CG + GG | Oral submucous fibrosis susceptibility | OR 1.05 [0.61, 1.80] GRADE not reported 3 studies · 506 participants |
| People with oral submucous fibrosis and healthy controls | TP53 rs1042522:G>C CC | TP53 rs1042522:G>C CG + GG | Oral submucous fibrosis susceptibility Sensitivity analysis: random effects | OR 1.09 [0.57, 2.10] GRADE not reported 3 studies · 506 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | TP53 rs1042522:G>C CC genotype | TP53 rs1042522:G>C CG + GG genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 1.05 [0.61, 1.80] GRADE not reported 3 studies · 506 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | TP53 rs1042522:G>C CC + CG genotype | TP53 rs1042522:G>C GG genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 0.92 [0.60, 1.42] GRADE not reported 3 studies · 506 participants |
| People with oral submucous fibrosis and healthy controls | TP53 rs1042522:G>C CC + CG | TP53 rs1042522:G>C GG | Oral submucous fibrosis susceptibility | OR 0.92 [0.60, 1.41] GRADE not reported 3 studies · 506 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | TP53 rs1042522:G>C CC + CG genotype | TP53 rs1042522:G>C GG genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 0.92 [0.60, 1.41] GRADE not reported 3 studies · 506 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | TP53 rs1042522:G>C C allele | TP53 rs1042522:G>C G allele | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 1.01 [0.75, 1.36] GRADE not reported 3 studies · 506 participants |
| People with oral submucous fibrosis and healthy controls | TP53 rs1042522:G>C C | TP53 rs1042522:G>C G | Oral submucous fibrosis susceptibility Sensitivity analysis: random effects | OR 0.57 [0.26, 1.28] GRADE not reported 3 studies · 506 participants |
| People with oral submucous fibrosis and healthy controls | TP53 rs1042522:G>C C | TP53 rs1042522:G>C G | Oral submucous fibrosis susceptibility | OR 1.01 [0.75, 1.36] GRADE not reported 3 studies · 506 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | TGFB1 rs1800469:T>C CC genotype | TGFB1 rs1800469:T>C TT genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 1.19 [0.68, 2.07] GRADE not reported 2 studies · 548 participants |
| People with oral submucous fibrosis and healthy controls | TGFB1 rs1800469:T > C CC | TGFB1 rs1800469:T > C TT | Oral submucous fibrosis susceptibility | OR 1.19 [0.68, 2.07] GRADE not reported 2 studies · 548 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | TGFB1 rs1800469:T>C CC genotype | TGFB1 rs1800469:T>C TT genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 1.19 [0.68, 2.07] GRADE not reported 2 studies · 548 participants |
| People with oral submucous fibrosis and healthy controls | TGFB1 rs1800469:T > C CT | TGFB1 rs1800469:T > C TT | Oral submucous fibrosis susceptibility Sensitivity analysis: random effects | OR 0.82 [0.50, 1.36] GRADE not reported 2 studies · 548 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | TGFB1 rs1800469:T>C CT genotype | TGFB1 rs1800469:T>C TT genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 0.80 [0.52, 1.23] GRADE not reported 2 studies · 548 participants |
| People with oral submucous fibrosis and healthy controls | TGFB1 rs1800469:T > C CT | TGFB1 rs1800469:T > C TT | Oral submucous fibrosis susceptibility | OR 0.80 [0.52, 1.23] GRADE not reported 2 studies · 548 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | TGFB1 rs1800469:T>C CC genotype | TGFB1 rs1800469:T>C CT + TT genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 1.44 [0.90, 2.31] GRADE not reported 2 studies · 548 participants |
| People with oral submucous fibrosis and healthy controls | TGFB1 rs1800469:T > C CC | TGFB1 rs1800469:T > C CT + TT | Oral submucous fibrosis susceptibility | OR 1.44 [0.90, 2.31] GRADE not reported 2 studies · 548 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | TGFB1 rs1800469:T>C CC genotype | TGFB1 rs1800469:T>C CT + TT genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 1.44 [0.90, 2.31] GRADE not reported 2 studies · 548 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | TGFB1 rs1800469:T>C CC + CT genotype | TGFB1 rs1800469:T>C TT genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: random-effects model | OR 0.90 [0.60, 1.35] GRADE not reported 2 studies · 548 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | TGFB1 rs1800469:T>C CC + CT genotype | TGFB1 rs1800469:T>C TT genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 0.90 [0.60, 1.35] GRADE not reported 2 studies · 548 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | TGFB1 rs1800469:T>C CC + CT genotype | TGFB1 rs1800469:T>C TT genotype | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) | OR 0.90 [0.60, 1.35] GRADE not reported 2 studies · 548 participants |
| People with oral submucous fibrosis and healthy controls | TGFB1 rs1800469:T > C C | TGFB1 rs1800469:T > C T | Oral submucous fibrosis susceptibility Sensitivity analysis: random effects | OR 1.07 [0.82, 1.40] GRADE not reported 2 studies · 548 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | TGFB1 rs1800469:T>C C allele | TGFB1 rs1800469:T>C T allele | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Sensitivity analysis: fixed-effect model | OR 0.90 [0.60, 1.35] GRADE not reported 2 studies · 548 participants |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | TGFB1 rs1800469:T>C C allele | TGFB1 rs1800469:T>C T allele | Risk of oral submucous fibrosis (genetic association) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) | OR 0.90 [0.60, 1.35] GRADE not reported 2 studies · 548 participants |
| People with oral submucous fibrosis and healthy controls | Network group 1 A1 | Network group 1 C3 | Oral submucous fibrosis susceptibility Direct evidence | SMD of network OR -2.23 [-4.81, 0.36] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A1 | Network group 1 C3 | Oral submucous fibrosis susceptibility Overall network estimate | SMD of network OR -1.98 [-3.94, -0.10] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A1 | Network group 1 C3 | Oral submucous fibrosis susceptibility Indirect evidence | SMD of network OR -1.94 [-4.69, 0.77] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A1 | Network group 1 C3 | Oral submucous fibrosis susceptibility Network league table; direction of ratio not stated | OR 0.14 [0.02, 0.90] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A1 | Network group 1 D3 | Oral submucous fibrosis susceptibility Direct evidence | SMD of network OR -1.30 [-3.91, 1.32] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A1 | Network group 1 D3 | Oral submucous fibrosis susceptibility Indirect evidence | SMD of network OR -1.09 [-3.89, 1.65] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A1 | Network group 1 D3 | Oral submucous fibrosis susceptibility Network league table; direction of ratio not stated | OR 0.35 [0.05, 2.35] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A1 | Network group 1 D3 | Oral submucous fibrosis susceptibility Overall network estimate | SMD of network OR -1.05 [-2.99, 0.85] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A2 | Network group 1 C3 | Oral submucous fibrosis susceptibility Direct evidence | SMD of network OR -2.20 [-4.80, 0.48] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A2 | Network group 1 C3 | Oral submucous fibrosis susceptibility Indirect evidence | SMD of network OR -2.70 [-5.47, 0.03] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A2 | Network group 1 C3 | Oral submucous fibrosis susceptibility Overall network estimate | SMD of network OR -2.70 [-4.63, -0.85] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A2 | Network group 1 D3 | Oral submucous fibrosis susceptibility Overall network estimate | SMD of network OR -1.77 [-3.65, 0.13] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A2 | Network group 1 D3 | Oral submucous fibrosis susceptibility Indirect evidence | SMD of network OR -1.82 [-4.62, 0.89] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A2 | Network group 1 D3 | Oral submucous fibrosis susceptibility Direct evidence | SMD of network OR -1.21 [-3.76, 1.36] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A3 | Network group 1 C3 | Oral submucous fibrosis susceptibility Overall network estimate | SMD of network OR -0.93 [-2.75, 0.93] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A3 | Network group 1 C3 | Oral submucous fibrosis susceptibility Indirect evidence | SMD of network OR -0.90 [-3.61, 1.84] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A3 | Network group 1 C3 | Oral submucous fibrosis susceptibility Direct evidence | SMD of network OR -0.95 [-3.53, 1.61] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A3 | Network group 1 D3 | Oral submucous fibrosis susceptibility Overall network estimate | SMD of network OR 0.01 [-1.84, 1.87] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A3 | Network group 1 D3 | Oral submucous fibrosis susceptibility Indirect evidence | SMD of network OR -0.04 [-2.93, 2.74] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A3 | Network group 1 D3 | Oral submucous fibrosis susceptibility Direct evidence | SMD of network OR -0.01 [-2.63, 2.63] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A4 | Network group 1 C3 | Oral submucous fibrosis susceptibility Indirect evidence | SMD of network OR -2.83 [-5.59, -0.17] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A4 | Network group 1 C3 | Oral submucous fibrosis susceptibility Overall network estimate | SMD of network OR -2.87 [-4.80, -1.01] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A4 | Network group 1 C3 | Oral submucous fibrosis susceptibility Direct evidence | SMD of network OR -2.90 [-5.50, -0.30] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A4 | Network group 1 D3 | Oral submucous fibrosis susceptibility Overall network estimate | SMD of network OR -1.92 [-3.85, -0.06] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A4 | Network group 1 D3 | Oral submucous fibrosis susceptibility Direct evidence | SMD of network OR -1.94 [-4.55, 0.69] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A4 | Network group 1 D3 | Oral submucous fibrosis susceptibility Indirect evidence | SMD of network OR -1.97 [-4.64, 0.75] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A5 | Network group 1 C3 | Oral submucous fibrosis susceptibility Direct evidence | SMD of network OR -1.79 [-4.35, 0.74] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A5 | Network group 1 C3 | Oral submucous fibrosis susceptibility Overall network estimate | SMD of network OR -2.60 [-4.48, -0.83] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A5 | Network group 1 C3 | Oral submucous fibrosis susceptibility Indirect evidence | SMD of network OR -2.60 [-5.26, 0.12] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A5 | Network group 1 D3 | Oral submucous fibrosis susceptibility Overall network estimate | SMD of network OR -1.66 [-3.52, 0.14] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A5 | Network group 1 D3 | Oral submucous fibrosis susceptibility Indirect evidence | SMD of network OR -1.71 [-4.45, 0.95] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A5 | Network group 1 D3 | Oral submucous fibrosis susceptibility Direct evidence | SMD of network OR -0.85 [-3.44, 1.73] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 B1 | Network group 1 C3 | Oral submucous fibrosis susceptibility Indirect evidence | SMD of network OR -3.28 [-6.01, -0.62] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 B1 | Network group 1 C3 | Oral submucous fibrosis susceptibility Overall network estimate | SMD of network OR -3.31 [-5.13, -1.57] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 B1 | Network group 1 C3 | Oral submucous fibrosis susceptibility Direct evidence | SMD of network OR -3.51 [-6.29, -0.94] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 B1 | Network group 1 D3 | Oral submucous fibrosis susceptibility Overall network estimate | SMD of network OR -2.38 [-4.18, -0.67] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 B1 | Network group 1 D3 | Oral submucous fibrosis susceptibility Direct evidence | SMD of network OR -2.61 [-5.37, 0.08] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 B1 | Network group 1 D3 | Oral submucous fibrosis susceptibility Indirect evidence | SMD of network OR -2.44 [-5.20, 0.19] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C CT vs TT (heterozygous model) [node A2] | CYP1A1 rs4646903:T>C CC vs CT + TT (recessive model) [node A3] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 0.17 [0.03, 0.98] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 B2 | Network group 1 C3 | Oral submucous fibrosis susceptibility Direct evidence | SMD of network OR -1.81 [-4.59, 0.72] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C CT vs TT (heterozygous model) [node A2] | CYP1A1 rs4646903:T>C CC + CT vs TT (dominant model) [node A4] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 1.17 [0.21, 6.98] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 B2 | Network group 1 C3 | Oral submucous fibrosis susceptibility Overall network estimate | SMD of network OR -0.30 [-2.07, 1.84] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 B2 | Network group 1 C3 | Oral submucous fibrosis susceptibility Indirect evidence | SMD of network OR -0.21 [-2.74, 2.85] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 B2 | Network group 1 D3 | Oral submucous fibrosis susceptibility Direct evidence | SMD of network OR -0.88 [-3.80, 1.74] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C CT vs TT (heterozygous model) [node A2] | CYP1A1 rs4646903:T>C C vs T (allelic model) [node A5] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 0.91 [0.17, 4.96] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 B2 | Network group 1 D3 | Oral submucous fibrosis susceptibility Indirect evidence | SMD of network OR 0.64 [-2.00, 3.61] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 B2 | Network group 1 D3 | Oral submucous fibrosis susceptibility Overall network estimate | SMD of network OR 0.63 [-1.12, 2.77] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 B3 | Network group 1 C3 | Oral submucous fibrosis susceptibility Indirect evidence | SMD of network OR -2.80 [-5.53, -0.18] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 B3 | Network group 1 C3 | Oral submucous fibrosis susceptibility Direct evidence | SMD of network OR -2.11 [-4.70, 0.45] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 B3 | Network group 1 C3 | Oral submucous fibrosis susceptibility Overall network estimate | SMD of network OR -2.81 [-4.59, -1.08] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C CT vs TT (heterozygous model) [node A2] | CYP1A1 rs1048943:A>G GG vs AA (homozygous model) [node B1] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 1.84 [0.36, 9.64] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 B3 | Network group 1 D3 | Oral submucous fibrosis susceptibility Overall network estimate | SMD of network OR -1.88 [-3.67, -0.13] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C CT vs TT (heterozygous model) [node A2] | CYP1A1 rs1048943:A>G GA vs AA (heterozygous model) [node B2] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 0.09 [0.01, 0.48] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 B3 | Network group 1 D3 | Oral submucous fibrosis susceptibility Direct evidence | SMD of network OR -1.16 [-3.81, 1.55] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 B3 | Network group 1 D3 | Oral submucous fibrosis susceptibility Indirect evidence | SMD of network OR -1.90 [-4.54, 0.72] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C CT vs TT (heterozygous model) [node A2] | CYP1A1 rs1048943:A>G GG vs GA + AA (recessive model) [node B3] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 1.12 [0.23, 5.66] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 B4 | Network group 1 C3 | Oral submucous fibrosis susceptibility Overall network estimate | SMD of network OR -3.37 [-5.16, -1.68] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 B4 | Network group 1 C3 | Oral submucous fibrosis susceptibility Indirect evidence | SMD of network OR -3.37 [-6.04, -0.75] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 B4 | Network group 1 C3 | Oral submucous fibrosis susceptibility Direct evidence | SMD of network OR -3.77 [-6.42, -1.12] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 B4 | Network group 1 D3 | Oral submucous fibrosis susceptibility Indirect evidence | SMD of network OR -2.49 [-5.18, 0.16] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 B4 | Network group 1 D3 | Oral submucous fibrosis susceptibility Direct evidence | SMD of network OR -2.78 [-5.49, -0.19] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 B4 | Network group 1 D3 | Oral submucous fibrosis susceptibility Overall network estimate | SMD of network OR -2.43 [-4.21, -0.73] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C CT vs TT (heterozygous model) [node A2] | CYP1A1 rs1048943:A>G GG + GA vs AA (dominant model) [node B4] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 1.97 [0.39, 10.34] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 B5 | Network group 1 C3 | Oral submucous fibrosis susceptibility Overall network estimate | SMD of network OR -3.01 [-4.79, -1.29] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 B5 | Network group 1 C3 | Oral submucous fibrosis susceptibility Direct evidence | SMD of network OR -2.74 [-5.23, -0.18] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C CT vs TT (heterozygous model) [node A2] | CYP1A1 rs1048943:A>G G vs A (allelic model) [node B5] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 1.37 [0.27, 7.24] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 B5 | Network group 1 C3 | Oral submucous fibrosis susceptibility Indirect evidence | SMD of network OR -3.02 [-5.73, -0.43] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 B5 | Network group 1 D3 | Oral submucous fibrosis susceptibility Indirect evidence | SMD of network OR -2.12 [-4.87, 0.56] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 B5 | Network group 1 D3 | Oral submucous fibrosis susceptibility Direct evidence | SMD of network OR -1.74 [-4.39, 0.90] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C CT vs TT (heterozygous model) [node A2] | GSTT1 null genotype Null genotype (-/-) vs Active genotype (+/+ and +/-) (recessive model) [node C3] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 0.07 [0.01, 0.43] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 B5 | Network group 1 D3 | Oral submucous fibrosis susceptibility Overall network estimate | SMD of network OR -2.08 [-3.81, -0.39] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C CT vs TT (heterozygous model) [node A2] | GSTM1 null genotype Null genotype (-/-) vs Active genotype (+/+ and +/-) (recessive model) [node D3] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 0.17 [0.03, 1.14] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A1 | Network group 1 A2 | Oral submucous fibrosis susceptibility Network league table; direction of ratio not stated | OR 2.05 [0.34, 12.55] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A1 | Network group 1 A3 | Oral submucous fibrosis susceptibility Network league table; direction of ratio not stated | OR 0.34 [0.06, 2.26] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C CC vs CT + TT (recessive model) [node A3] | CYP1A1 rs4646903:T>C CC + CT vs TT (dominant model) [node A4] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 7.03 [1.23, 41.19] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A1 | Network group 1 A4 | Oral submucous fibrosis susceptibility Network league table; direction of ratio not stated | OR 2.43 [0.41, 14.41] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C CC vs CT + TT (recessive model) [node A3] | CYP1A1 rs4646903:T>C C vs T (allelic model) [node A5] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 5.33 [0.97, 30.42] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C CC vs CT + TT (recessive model) [node A3] | CYP1A1 rs1048943:A>G GG vs AA (homozygous model) [node B1] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 10.87 [2.15, 57.33] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A1 | Network group 1 A5 | Oral submucous fibrosis susceptibility Network league table; direction of ratio not stated | OR 1.86 [0.31, 10.90] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C CC vs CT + TT (recessive model) [node A3] | CYP1A1 rs1048943:A>G GA vs AA (heterozygous model) [node B2] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 0.53 [0.07, 2.77] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A1 | Network group 1 B1 | Oral submucous fibrosis susceptibility Network league table; direction of ratio not stated | OR 3.76 [0.72, 20.91] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C CC vs CT + TT (recessive model) [node A3] | CYP1A1 rs1048943:A>G GG vs GA + AA (recessive model) [node B3] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 6.61 [1.37, 33.54] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A1 | Network group 1 B2 | Oral submucous fibrosis susceptibility Network league table; direction of ratio not stated | OR 0.18 [0.02, 1.06] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A1 | Network group 1 B3 | Oral submucous fibrosis susceptibility Network league table; direction of ratio not stated | OR 2.29 [0.43, 12.37] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C CC vs CT + TT (recessive model) [node A3] | CYP1A1 rs1048943:A>G GG + GA vs AA (dominant model) [node B4] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 11.79 [2.30, 61.36] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A1 | Network group 1 B4 | Oral submucous fibrosis susceptibility Network league table; direction of ratio not stated | OR 3.99 [0.76, 22.91] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C CC vs CT + TT (recessive model) [node A3] | CYP1A1 rs1048943:A>G G vs A (allelic model) [node B5] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 8.09 [1.65, 41.71] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 1 A1 | Network group 1 B5 | Oral submucous fibrosis susceptibility Network league table; direction of ratio not stated | OR 2.82 [0.57, 15.10] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C CC vs CT + TT (recessive model) [node A3] | GSTT1 null genotype Null genotype (-/-) vs Active genotype (+/+ and +/-) (recessive model) [node C3] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 0.40 [0.06, 2.53] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 2 E1 | Network group 2 E3 | Oral submucous fibrosis susceptibility Network league table; direction of ratio not stated | OR 0.62 [0.22, 1.80] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C CC vs CT + TT (recessive model) [node A3] | GSTM1 null genotype Null genotype (-/-) vs Active genotype (+/+ and +/-) (recessive model) [node D3] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 1.01 [0.16, 6.50] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 2 E1 | Network group 2 E5 | Oral submucous fibrosis susceptibility Network league table; direction of ratio not stated | OR 2.13 [0.82, 5.69] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C CC + CT vs TT (dominant model) [node A4] | CYP1A1 rs4646903:T>C C vs T (allelic model) [node A5] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 0.77 [0.14, 4.11] GRADE not reported Studies not reported |
| People with oral submucous fibrosis and healthy controls | Network group 3 F3 | Network group 3 F5 | Oral submucous fibrosis susceptibility Network league table; direction of ratio not stated | OR 2.17 [1.03, 4.64] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C CC + CT vs TT (dominant model) [node A4] | CYP1A1 rs1048943:A>G GG vs AA (homozygous model) [node B1] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 1.58 [0.32, 8.07] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C CC + CT vs TT (dominant model) [node A4] | CYP1A1 rs1048943:A>G GA vs AA (heterozygous model) [node B2] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 0.08 [0.01, 0.39] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C CC + CT vs TT (dominant model) [node A4] | CYP1A1 rs1048943:A>G GG vs GA + AA (recessive model) [node B3] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 0.96 [0.19, 4.72] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C CC + CT vs TT (dominant model) [node A4] | CYP1A1 rs1048943:A>G GG + GA vs AA (dominant model) [node B4] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 1.68 [0.34, 8.68] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C CC + CT vs TT (dominant model) [node A4] | CYP1A1 rs1048943:A>G G vs A (allelic model) [node B5] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 1.16 [0.24, 5.74] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C CC + CT vs TT (dominant model) [node A4] | GSTT1 null genotype Null genotype (-/-) vs Active genotype (+/+ and +/-) (recessive model) [node C3] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 0.06 [0.01, 0.36] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C CC + CT vs TT (dominant model) [node A4] | GSTM1 null genotype Null genotype (-/-) vs Active genotype (+/+ and +/-) (recessive model) [node D3] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 0.15 [0.02, 0.94] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C C vs T (allelic model) [node A5] | CYP1A1 rs1048943:A>G GG vs AA (homozygous model) [node B1] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 2.04 [0.40, 10.28] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C C vs T (allelic model) [node A5] | CYP1A1 rs1048943:A>G GA vs AA (heterozygous model) [node B2] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 0.10 [0.01, 0.50] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C C vs T (allelic model) [node A5] | CYP1A1 rs1048943:A>G GG vs GA + AA (recessive model) [node B3] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 1.23 [0.25, 5.90] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C C vs T (allelic model) [node A5] | CYP1A1 rs1048943:A>G GG + GA vs AA (dominant model) [node B4] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 2.16 [0.44, 10.79] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C C vs T (allelic model) [node A5] | CYP1A1 rs1048943:A>G G vs A (allelic model) [node B5] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 1.53 [0.31, 7.32] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C C vs T (allelic model) [node A5] | GSTT1 null genotype Null genotype (-/-) vs Active genotype (+/+ and +/-) (recessive model) [node C3] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 0.07 [0.01, 0.43] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs4646903:T>C C vs T (allelic model) [node A5] | GSTM1 null genotype Null genotype (-/-) vs Active genotype (+/+ and +/-) (recessive model) [node D3] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 0.19 [0.03, 1.15] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs1048943:A>G GG vs AA (homozygous model) [node B1] | CYP1A1 rs1048943:A>G GA vs AA (heterozygous model) [node B2] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 0.05 [0.01, 0.22] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs1048943:A>G GG vs AA (homozygous model) [node B1] | CYP1A1 rs1048943:A>G GG vs GA + AA (recessive model) [node B3] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 0.60 [0.15, 2.45] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs1048943:A>G GG vs AA (homozygous model) [node B1] | CYP1A1 rs1048943:A>G GG + GA vs AA (dominant model) [node B4] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 1.06 [0.25, 4.49] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs1048943:A>G GG vs AA (homozygous model) [node B1] | CYP1A1 rs1048943:A>G G vs A (allelic model) [node B5] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 0.74 [0.18, 2.98] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs1048943:A>G GG vs AA (homozygous model) [node B1] | GSTT1 null genotype Null genotype (-/-) vs Active genotype (+/+ and +/-) (recessive model) [node C3] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 0.04 [0.01, 0.21] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs1048943:A>G GG vs AA (homozygous model) [node B1] | GSTM1 null genotype Null genotype (-/-) vs Active genotype (+/+ and +/-) (recessive model) [node D3] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 0.09 [0.02, 0.51] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs1048943:A>G GA vs AA (heterozygous model) [node B2] | CYP1A1 rs1048943:A>G GG vs GA + AA (recessive model) [node B3] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 12.32 [2.78, 83.71] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs1048943:A>G GA vs AA (heterozygous model) [node B2] | CYP1A1 rs1048943:A>G GG + GA vs AA (dominant model) [node B4] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 21.47 [4.98, 151.23] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs1048943:A>G GA vs AA (heterozygous model) [node B2] | CYP1A1 rs1048943:A>G G vs A (allelic model) [node B5] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 15.22 [3.48, 102.30] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs1048943:A>G GA vs AA (heterozygous model) [node B2] | GSTT1 null genotype Null genotype (-/-) vs Active genotype (+/+ and +/-) (recessive model) [node C3] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 0.74 [0.13, 6.29] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs1048943:A>G GA vs AA (heterozygous model) [node B2] | GSTM1 null genotype Null genotype (-/-) vs Active genotype (+/+ and +/-) (recessive model) [node D3] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 1.87 [0.32, 15.90] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs1048943:A>G GG vs GA + AA (recessive model) [node B3] | CYP1A1 rs1048943:A>G GG + GA vs AA (dominant model) [node B4] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 1.76 [0.43, 7.46] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs1048943:A>G GG vs GA + AA (recessive model) [node B3] | CYP1A1 rs1048943:A>G G vs A (allelic model) [node B5] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 1.23 [0.30, 4.82] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs1048943:A>G GG vs GA + AA (recessive model) [node B3] | GSTT1 null genotype Null genotype (-/-) vs Active genotype (+/+ and +/-) (recessive model) [node C3] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 0.06 [0.01, 0.34] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs1048943:A>G GG vs GA + AA (recessive model) [node B3] | GSTM1 null genotype Null genotype (-/-) vs Active genotype (+/+ and +/-) (recessive model) [node D3] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 0.15 [0.03, 0.88] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs1048943:A>G GG + GA vs AA (dominant model) [node B4] | CYP1A1 rs1048943:A>G G vs A (allelic model) [node B5] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 0.70 [0.17, 2.82] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs1048943:A>G GG + GA vs AA (dominant model) [node B4] | GSTT1 null genotype Null genotype (-/-) vs Active genotype (+/+ and +/-) (recessive model) [node C3] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 0.03 [0.01, 0.19] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs1048943:A>G GG + GA vs AA (dominant model) [node B4] | GSTM1 null genotype Null genotype (-/-) vs Active genotype (+/+ and +/-) (recessive model) [node D3] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 0.09 [0.01, 0.48] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs1048943:A>G G vs A (allelic model) [node B5] | GSTT1 null genotype Null genotype (-/-) vs Active genotype (+/+ and +/-) (recessive model) [node C3] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 0.05 [0.01, 0.28] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | CYP1A1 rs1048943:A>G G vs A (allelic model) [node B5] | GSTM1 null genotype Null genotype (-/-) vs Active genotype (+/+ and +/-) (recessive model) [node D3] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 0.13 [0.02, 0.68] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | GSTT1 null genotype Null genotype (-/-) vs Active genotype (+/+ and +/-) (recessive model) [node C3] | GSTM1 null genotype Null genotype (-/-) vs Active genotype (+/+ and +/-) (recessive model) [node D3] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 1: league table | OR 2.53 [0.76, 8.73] GRADE not reported Studies not reported |
| Patients diagnosed with oral submucous fibrosis (cases) and healthy controls | XRCC3 rs861539:C>T TT vs TC + CC (recessive model) [node E3] | XRCC3 rs861539:C>T T vs C (allelic model) [node E5] | Relative strength of association with oral submucous fibrosis risk between genetic models (Bayesian network meta-analysis) Case-control genetic association studies in Asian populations (India, Taiwan, Pakistan) · Network meta-analysis group 2: league table | OR 3.41 [1.34, 9.43] GRADE not reported Studies not reported |
Included primary studies 46
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Madhulatha 2018 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| Agrawal 2010 Role of GSTM1 and GSTT1 polymorphism: susceptibility to oral submucous fibrosis in the North Indian population. PMID:21358205 | 2010 | this review only | not stated | not extracted yet |
| Agrawal D, 2010 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Chaudhary 2010 (MMP1) Functional polymorphism of the MMP-1 promoter (-1607 1G/2G) in potentially malignant and malignant head and neck lesions in an Indian… PMID:20860530 | 2010 | this review only | not stated | not extracted yet |
| Chaudhary 2010 (MMP3) Synergistic effect of stromelysin-1 (matrix metalloproteinase-3) promoter (-1171 5A->6A) polymorphism in oral submucous fibrosis and head… PMID:20630073 | 2010 | this review only | not stated | not extracted yet |
| Chaudhary 2011 (MMP2/MMP9) Role of functional polymorphism of matrix metalloproteinase-2 (-1306 C/T and -168 G/T) and MMP-9 (-1562 C/T) promoter in oral submucous… PMID:21958210 | 2011 | this review only | not stated | not extracted yet |
| Chaudhary AK, 2010 (1) matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Chaudhary AK, 2011 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Chaudhuri 2013 CYP1AI and CYP2E1 gene polymorphisms may increase susceptibility to oral submucous fibrosis among betel quid chewers of eastern India. PMID:23124075 | 2013 | this review only | not stated | not extracted yet |
| Chaudhuri SR, 2013 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Chiu 2002 Interaction of collagen-related genes and susceptibility to betel quid-induced oral submucous fibrosis. PMID:12101112 | 2002 | this review only | not stated | not extracted yet |
| Chiu CJ, 2002 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Ghosh 2012 Association of CYP1A1, GSTM1, and GSTT1 gene polymorphism with risk of oral submucous fibrosis in a section of North Indian population. PMID:22752755 | 2012 | this review only | not stated | not extracted yet |
| Ghosh T, 2012 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Hallikeri 2018 p53 polymorphism and association of human papillomavirus in oral submucous fibrosis and oral squamous cell carcinoma: A case-control study. PMID:31110424 | 2019 | this review only | not stated | not extracted yet |
| Hallikeri K, 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Katarkar 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Katarkar A, 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Lin SC 2004 (MMP1) Correlation between functional genotypes in the matrix metalloproteinases-1 promoter and risk of oral squamous cell carcinomas. PMID:15200479 | 2004 | this review only | not stated | not extracted yet |
| Lin SC 2004 (MMP2) Functional genotype in matrix metalloproteinases-2 promoter is a risk factor for oral carcinogenesis. PMID:15250832 | 2004 | this review only | not stated | not extracted yet |
| Lin SC, 2004 (1) matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Lin YC 2008 Polymorphisms of COX-2 -765G>C and p53 codon 72 and risks of oral squamous cell carcinoma in a Taiwan population. PMID:18234542 | 2008 | this review only | not stated | not extracted yet |
| Lin YC, 2008 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Madhulatha G, 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Majumdar 2013 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Majumdar PK, 2013 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Mannan 2024 Association of Oral Submucous Fibrosis Risk with <em>GSTM1</em> and <em>GSTT1</em> Gene Polymorphisms. PMID:38462864 | 2024 | this review only | not stated | not extracted yet |
| Mannan A, 2024 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Mukherjee 2011 Association of XRCC1, XRCC3, and NAT2 polymorphisms with the risk of oral submucous fibrosis among eastern Indian population. PMID:22092501 | 2012 | this review only | not stated | not extracted yet |
| Mukherjee 2021 Effect of Lysyl Oxidase G473 A Polymorphism on Lysyl Oxidase and Total Soluble Collagen Expression in Oral Submucous Fibrosis. PMID:34452563 | 2021 | this review only | not stated | not extracted yet |
| Mukherjee S, 2011 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Mukherjee S, 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Nigam 2023 XRCC3 and NBS1 gene polymorphisms modulate the risk of pre-oral cancer and oral cancer in the North Indian population. PMID:37006067 | 2023 | this review only | not stated | not extracted yet |
| Nigam K, 2023 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Rajendran 2010 Transforming growth factor-β-1 polymorphisms are infrequent but exist at selected loci in oral submucous fibrosis. PMID:20930355 | 2010 | this review only | not stated | not extracted yet |
| Rajendran R, 2010 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Shieh 2009 Association between lysyl oxidase polymorphisms and oral submucous fibrosis in older male areca chewers. PMID:18764858 | 2009 | this review only | not stated | not extracted yet |
| Shieh TM, 2009 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Tu 2006 The functional (-1171 5A-->6A) polymorphisms of matrix metalloproteinase 3 gene as a risk factor for oral submucous fibrosis among male… PMID:16430740 | 2006 | this review only | not stated | not extracted yet |
| Tu 2007 Functional -1562 C-to-T polymorphism in matrix metalloproteinase-9 (MMP-9) promoter is associated with the risk for oral squamous cell… PMID:17617834 | 2007 | this review only | not stated | not extracted yet |
| Tu 2008 MDM2 SNP 309 and p53 codon 72 polymorphisms are associated with the outcome of oral carcinoma patients receiving postoperative irradiation. PMID:18423915 | 2008 | this review only | not stated | not extracted yet |
| Tu HF, 2006 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Tu HF, 2007 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Tu HF, 2008 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Yaming 2016 Roles of CYP1A1 and CYP2E1 Gene Polymorphisms in Oral Submucous Fibrosis. PMID:27509973 | 2016 | this review only | not stated | not extracted yet |
| Yaming P, 2016 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
| Review | Shared studies | Jaccard |
|---|---|---|
| Systematic evaluation of genetic polymorphisms in carcinogen metabolizing enzymes associated with oral potentially malignant disorders… (2026) | 1 | 0.02 |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients diagnosed with oral submucous fibrosis (not precancerous lesions or other potentially malignant disorders) compared with healthy controls | Patients with oral submucous fibrosis and healthy controls, 2545 cases and 3772 controls (n=24 studies; India, Taiwan, Pakistan; Asian ethnicity) |
| Intervention | Gene SNP genotype or allele frequencies (genetic models: homozygous, heterozygous, recessive, dominant, allelic) | 13 SNPs in 11 genes: LOX rs1800449, CYP1A1 rs4646903 and rs1048943, GSTT1 null, GSTM1 null, MMP1 rs1799750, MMP2 rs243865, MMP3 rs3025058, MMP9 rs3918242 and rs17576, XRCC3 rs861539, TP53 rs1042522, TGFB1 rs1800469 (n=24) |
| Comparison | Reference genotype or allele (wild type) in healthy controls | Reference genotype or allele in healthy controls |
| Outcomes | Risk of oral submucous fibrosis (OR with 95% CI); ranking of genetic models by Bayesian network meta-analysis | Risk of oral submucous fibrosis (pairwise OR, FPRP); relative strength of association between genetic models (network OR, rank probabilities) in 3 network groups |
| Study designs | Full-text case-control studies with sufficient genotype information; at least 2 reports per SNP; quality score of 7 or more | Case-control studies (n=24) |
| Timing | Not specified | Not specified |