Maternal vitamin D concentration at term (25‐hydroxyvitamin D) (nmol/L) (ALL) · pregnant women
Meta-analysis of randomised trials of vitamin D supplementation for Maternal vitamin D concentrations at term: WMD 47.08 (95% CI 23.76 to 70.39), statistically significant. Umbrella review outcome-level evidence grade: Probable.
1 finding from 1 review
WMD 47.08 [23.76, 70.39]
4 studies
GRADE not reported
Dental caries in children · Infants and children (aged about 2 to 8 years) whose mothers' vitamin D status was assessed during pregnancy
For prenatal vitamin D measured across gestational weeks 6-38, the OR of dental caries was 1.32 (no CI reported); ungraded.
3 findings from 1 review
Dental caries in children · Children aged 6 to 8 years whose mothers' prenatal vitamin D status was assessed
In the single study of children aged 6-8 years, the association was not statistically significant (OR 1.07, 95% CI 0.84-1.30); ungraded.
1 finding from 1 review
Association between prenatal vitamin D deficiency with dental caries in infants and children: a systematic review and… 2024 All outcomesPrenatal exposure; dental caries at 6 to 8 years · Observational pregnancy/birth-cohort studies (one cross-sectional), mostly in developed countries (USA, Canada, Japan, Australia, Spain, Netherlands, Poland, New Zealand, Turkey) · Children's age subgroup: 6 to 8 years
OR 1.07 [0.84, 1.30]
1 study
GRADE not reported
Dental caries in children · Children aged 4 to 6 years whose mothers' prenatal vitamin D status was assessed
Among children aged 4-6 years, prenatal vitamin D deficiency is associated with significantly higher odds of dental caries (OR 1.44, 95% CI 1.32-1.56); ungraded.
1 finding from 1 review
Association between prenatal vitamin D deficiency with dental caries in infants and children: a systematic review and… 2024 All outcomesPrenatal exposure; dental caries at 4 to 6 years · Observational pregnancy/birth-cohort studies (one cross-sectional), mostly in developed countries (USA, Canada, Japan, Australia, Spain, Netherlands, Poland, New Zealand, Turkey) · Children's age subgroup: 4 to 6 years
OR 1.44 [1.32, 1.56]
8 studies
GRADE not reported
Dental caries in children · Infants and children (aged about 2 to 8 years) whose mothers' vitamin D status was assessed during pregnancy
For prenatal vitamin D measured across gestational weeks 24-38, the OR of dental caries was 1.30 (no CI reported); ungraded.
1 finding from 1 review
Association between prenatal vitamin D deficiency with dental caries in infants and children: a systematic review and… 2024 All outcomesMaternal 25(OH)D measured at gestational weeks 24 to 38 · Observational pregnancy/birth-cohort studies (one cross-sectional), mostly in developed countries (USA, Canada, Japan, Australia, Spain, Netherlands, Poland, New Zealand, Turkey) · Gestational-age subgroup: weeks 24 to 38
OR 1.30 [1.15, 1.45]
4 studies
GRADE not reported
Dental caries · Children aged 2 to 8 years
The review reported a lower odds ratio at maternal prenatal vitamin D ≤50 nmol/L than at ≤35 nmol/L, without a numeric value in the available sources.
1 finding from 1 review
Dental caries · Children aged 2 to 8 years
The review reported a slightly higher odds ratio at maternal prenatal vitamin D ≤35 nmol/L than at ≤50 nmol/L, without a numeric value in the available sources.
1 finding from 1 review
Dental caries prevalence · Children aged 2 to 8 years
The review reported 44% dental caries prevalence among children of mothers with low prenatal vitamin D.
2 findings from 1 review
Dental caries · Children aged 2 to 8 years
The review reported an OR of 1.32 when prenatal vitamin D was measured at 6 to 38 gestational weeks.
2 findings from 1 review
Mucositis eradicated · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis
Vitamin E showed no clear difference in mucositis eradicated compared with placebo (not a true placebo); GRADE not reported.
1 finding from 1 review
Dental caries · Children (<19 years)
Children with vitamin D deficiency had a 22% higher risk of dental caries than those with normal vitamin D levels (unadjusted RR 1.22; ungraded).
5 findings from 1 review
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RR 1.16 [1.10, 1.22]
Studies not reported
GRADE not reported
RR 1.05 [1.00, 1.09]
3 studies
GRADE not reported
Dental caries · Children with permanent dentition (>12 years)
In children with permanent dentition, vitamin D deficiency was associated with a 28% higher caries risk (RR 1.28; ungraded).
1 finding from 1 review
RR 1.28 [1.21, 1.35]
2 studies
GRADE not reported
Dental caries · Children with deciduous dentition (<6 years)
In children with deciduous dentition, vitamin D deficiency was associated with a 68% higher caries risk (RR 1.68; ungraded).
1 finding from 1 review
RR 1.68 [1.57, 1.79]
6 studies
GRADE not reported
Dental caries · Children (mixed dentition; baseline about 8 years)
In children with mixed dentition, vitamin D deficiency was associated with an 8% higher caries risk (RR 1.08; ungraded).
1 finding from 1 review
RR 1.08 [1.04, 1.12]
4 studies
GRADE not reported
Improvement in mucositis · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis
Vitamin E (topical) led to higher improvement in mucositis compared with vitamin E (swallowed); GRADE not reported.
1 finding from 1 review
Mucositis eradicated · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis
Vitamin E (topical) led to higher mucositis eradicated compared with vitamin E (swallowed); GRADE not reported.
1 finding from 1 review
Prostate cancer · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Prostate cancer: OR 1.04 (95% CI 0.98 to 1.09), not statistically significant. Umbrella review outcome-level evidence grade: Substantial effect unlikely.
1 finding from 1 review
Type 2 diabetes mellitus · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Type 2 diabetes: OR 0.63 (95% CI 0.56 to 0.69), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
Sporadic colorectal adenoma recurrence · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Sporadic colorectal adenoma recurrence: OR 0.87 (95% CI 0.57 to 1.33), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Ischaemic heart disease · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Ischaemic heart disease: HR 0.72 (95% CI 0.65 to 0.81), statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review