Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

49 questions · 49 findings · 10 reviews · ENT

No studies found 8 · 16.3%GRADE not reported 0 · 0%Very low 12 · 24.5%Low 16 · 32.7%Moderate 10 · 20.4%High 3 · 6.1%

Tranexamic acid vs placebo (saline solution or sterile water)

Overall rate of surgical complications · adults and children with chronic rhinosinusitis with or without nasal polyps

Tranexamic acid showed no clear difference in surgical complications compared with placebo (saline solution or sterile water) (moderate certainty).

1 finding from 1 review

Sinonasal debridement vs no debridement

Postoperative endoscopic appearance of the sinonasal surgical cavities: Lund‐Kennedy endoscopic score (range 1 to 10) · adult patients who underwent primary endoscopic sinus surgery, with a diagnosis of recurrent acute or chronic rhinosinusitis

Sinonasal debridement showed no clear difference in postoperative endoscopic appearance of the sinonasal surgical… compared with no debridement (low certainty).

1 finding from 1 review

Intervention not reported

Reduction in number and/or frequency of surgical interventions and/or time until first relapse requiring surgery · 23 patients aged two years or older with recurrent respiratory papillomatosis

The review found no eligible studies for this question.

1 finding from 1 review

Ventilation tubes vs no treatment

Improvement in frequency of vertigo (complete resolution) at > 12 months · Ménière’s disease

It is very uncertain whether ventilation tubes changes improvement in frequency of vertigo (complete resolution) at > 12… compared with no treatment (very low certainty).

1 finding from 1 review