Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

113 questions · 119 findings · 12 reviews · Urology

No studies found 38 · 31.9%GRADE not reported 0 · 0%Very low 43 · 36.1%Low 21 · 17.6%Moderate 16 · 13.4%High 1 · 0.8%

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs placebo or usual care

Major surgical complications · Percutaneous nephrolithotomy

Topical TXA showed no clear difference in major surgical complications compared with no TXA (placebo or usual care) (low certainty).

1 finding from 1 review

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs placebo or usual care

Minor surgical complications · Percutaneous nephrolithotomy

Topical TXA may leads to lower minor surgical complications compared with no TXA (placebo or usual care) (low certainty).

1 finding from 1 review

Combination therapy vs alpha‐blocker

Surgical intervention · men with lower urinary tract symptoms secondary to benign prostatic obstruction

It is very uncertain whether combination therapy changes surgical intervention compared with alpha‐blockers (very low certainty).

1 finding from 1 review

Posterior reconstruction vs no posterior reconstruction

Positive surgical margins MCID: 5% absolute difference · men (ages > 18 years) with clinically localized prostate cancer

Posterior reconstruction showed no clear difference in positive surgical margins MCID: 5% absolute difference compared with no posterior reconstruction (low certainty).

1 finding from 1 review

Retzius‐sparing RALP vs standard RALP

Positive surgical margins MCID: 5% absolute difference · men (ages > 18 years) with clinically localized prostate cancer

Retzius‐sparing RALP may leads to higher positive surgical margins MCID: 5% absolute difference compared with standard RALP (low certainty).

1 finding from 1 review

Laparaoscopic radical prostatectomy and robotic‐assisted laparoscopic radical prostatectomy vs open radical prostatectomy

Overall rate of surgical complications

Laparaoscopic radical prostatectomy and robotic‐assisted… showed no clear difference in overall surgical complications (short‐term) compared with open radical prostatectomy (low certainty).

1 finding from 1 review