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Evidence found and GRADE certainty

16 questions · 16 findings · 4 reviews

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No studies found 2 · 12.5%GRADE not reported 0 · 0%Very low 5 · 31.3%Low 4 · 25%Moderate 4 · 25%High 1 · 6.3%

Summary of findings table ‐ Continuation vs reduction of polypharmacy

Hospital readmission · patients with schizophrenia

It is very uncertain whether summary of findings table ‐ Continuation changes service use – readmission to hospital – total compared with reduction of polypharmacy (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Continuation vs reduction of polypharmacy

Adverse effects – leaving the study early due to adverse effects – overall tolerability – total · patients with schizophrenia

It is very uncertain whether summary of findings table ‐ Continuation changes adverse effects – leaving the study early due to adverse effects –… compared with reduction of polypharmacy (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Continuation vs reduction of polypharmacy

Leaving the study early ‐ for any reason ‐ overall acceptability (combined time points) · patients with schizophrenia

Summary of findings table ‐ Continuation may leads to lower leaving the study early due to any reason – overall acceptability… compared with reduction of polypharmacy (low certainty).

1 finding from 1 review

Summary of findings table ‐ Continuation vs reduction of polypharmacy

Adverse effects: ≥ 1 adverse effect – total · patients with schizophrenia

It is very uncertain whether summary of findings table ‐ Continuation changes adverse effects: ≥ 1 adverse effect – total compared with reduction of polypharmacy (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Systemic therapy vs control

Effect on discontinuation of aromatase inhibitors (AI) · women with early breast cancer

Summary of findings table ‐ Systemic therapy showed no clear difference in effect on discontinuation of aromatase inhibitors (AI) compared with control (low certainty).

1 finding from 1 review

Summary of findings table ‐ Antipsychotic dose reduction vs dose continuation

Hospital readmission · patients with schizophrenia

It is very uncertain whether summary of findings table ‐ Antipsychotic dose reduction changes service use ‐ readmission to hospital (combined time points) compared with dose continuation (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Antipsychotic dose reduction vs dose continuation

Withdrawals due to adverse events · patients with schizophrenia

Summary of findings table ‐ Antipsychotic dose reduction probably leads to higher adverse effect ‐ leaving the study early due to adverse effects ‐… compared with dose continuation (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Antipsychotic dose reduction vs dose continuation

Global state ‐ number of participants with relapse/exacerbations of psychosis (combined time points) · patients with schizophrenia

Summary of findings table ‐ Antipsychotic dose reduction may leads to higher global state ‐ number of participants with relapse/exacerbations of… compared with dose continuation (low certainty).

1 finding from 1 review

Summary of findings table ‐ Antipsychotic dose reduction vs dose continuation

Leaving the study early ‐ for any reason ‐ overall acceptability (combined time points) · patients with schizophrenia

Summary of findings table ‐ Antipsychotic dose reduction probably leads to higher leaving the study early ‐ for any reason ‐ overall acceptability… compared with dose continuation (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Antipsychotic dose reduction vs dose continuation

Participants with at least some Side Effects · patients with schizophrenia

Summary of findings table ‐ Antipsychotic dose reduction showed no clear difference in adverse effects ‐ number of participants with at least 1 adverse… compared with dose continuation (moderate certainty).

1 finding from 1 review