Number of respiratory exacerbations: requiring either IV antibiotics or hospitalisation · adults and children with CF
1 finding from 1 review
Adverse events during treatment · adults and children with cystic fibrosis
The review found no eligible studies for this question.
2 findings from 1 review
Death during the study · adults and children with sickle cell disease and an increased risk of stroke
1 finding from 1 review
Death during the study · people with sickle cell disease
1 finding from 1 review
All‐cause mortality · people with sickle cell disease
Summary of findings ‐ Hydroxyurea showed no clear difference in death during the study (all deaths) compared with placebo (moderate certainty).
Pulmonary exacerbations number of participants requiring IV antibiotics · children with cystic fibrosis
Summary of findings: Zinc supplementation showed no clear difference in pulmonary exacerbations number of participants requiring IV… compared with placebo (moderate certainty).
1 finding from 1 review
Adverse events number of participants hospitalised during the trial · children with cystic fibrosis
Summary of findings: Zinc supplementation showed no clear difference in adverse events number of participants hospitalised during the trial compared with placebo (moderate certainty).
1 finding from 1 review
Adverse events: occurring in at least 10% of cavosonstat treated participants · adults and children with cystic fibrosis
1 finding from 1 review
All‐cause mortality · adults and children with sickle cell disease and an increased risk of stroke
Summary of findings ‐ Hydroxyurea and phlebotomy showed no clear difference in death during the study (all deaths) compared with transfusion and chelation (low certainty).
1 finding from 1 review
Pulmonary exacerbations · adults and children with cystic fibrosis
1 finding from 1 review
Adverse events (moderate) · adults and children with cystic fibrosis (during acute exacerbations of lung disease)
It is very uncertain whether summary of findings: Inhaled antibiotics plus IV antibiotics changes adverse events moderate adverse events experienced during and after… compared with IV antibiotics only (very low certainty).
1 finding from 1 review
Adverse events: most commonly occurring events (occurring in at least 10% of participants) · adults and children with cystic fibrosis
1 finding from 1 review
Treatment time (seconds) · adults and children with cystic fibrosis
1 finding from 1 review
Quality of life · adults and children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Serum deposition Cmax · adults and children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse events · adults and children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Lung function: FEV1 mL (change from baseline) · adults and children with cystic fibrosis
1 finding from 1 review
Time to next exacerbation · adults and children with cystic fibrosis
1 finding from 1 review
Participant satisfaction or preference · adults and children with cystic fibrosis
Summary of findings ‐ nebulisers for delivering colistin:… may leads to lower participant satisfaction or preference compared with AAD (low certainty).
1 finding from 1 review
Serum deposition Cmax · adults and children with cystic fibrosis
1 finding from 1 review