Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

81 questions · 84 findings · 13 reviews · Neonatal

No studies found 1 · 1.2%GRADE not reported 16 · 19%Very low 30 · 35.7%Low 21 · 25%Moderate 14 · 16.7%High 2 · 2.4%

Respiratory support vs no respiratory support before cord clamping

Mortality ≤2 years after hospital discharge · preterm infants

Respiratory support showed no clear difference in mortality ≤2 years after hospital discharge compared with no respiratory support before cord clamping (low certainty).

1 finding from 1 review

Respiratory support vs no respiratory support before cord clamping

Blood transfusion during neonatal admission · preterm infants

Respiratory support showed no clear difference in blood transfusion during neonatal admission compared with no respiratory support before cord clamping (moderate certainty).

1 finding from 1 review

Respiratory support vs no respiratory support before cord clamping

Severe intraventricular haemorrhage · preterm infants

It is very uncertain whether respiratory support changes severe intraventricular haemorrhage grade 3 or 4 compared with no respiratory support before cord clamping (very low certainty).

1 finding from 1 review

HFNC vs continuous positive airway pressure (CPAP)

Death (before hospital discharge) or BPD (supplemental oxygen/respiratory support at 36 weeks' postmenstrual age if born < 32 weeks' gestation, or 28 days if born ≥ 32 weeks' gestation) · preterm infants requiring primary respiratory support

Nasal high flow showed no clear difference in death (before hospital discharge) or BPD(supplemental… compared with continuous positive airway pressure (low certainty).

1 finding from 1 review

HFNC vs nasal intermittent positive pressure ventilation

BPD (supplemental oxygen/respiratory support at 36 weeks' postmenstrual age if born < 32 weeks' gestation, or 28 days if born ≥ 32 weeks' gestation) · preterm infants requiring primary respiratory support

Nasal high flow showed no clear difference in BPD (supplemental oxygen/respiratory support at 36 weeks'… compared with nasal intermittent positive pressure ventilation (low certainty).

1 finding from 1 review

HFNC vs continuous positive airway pressure (CPAP)

BPD (supplemental oxygen/respiratory support at 36 weeks' postmenstrual age if born < 32 weeks' gestation, or 28 days if born ≥ 32 weeks' gestation) · preterm infants requiring primary respiratory support

Nasal high flow showed no clear difference in BPD (supplemental oxygen/respiratory support at 36 weeks'… compared with continuous positive airway pressure (low certainty).

1 finding from 1 review

HFNC vs nasal intermittent positive pressure ventilation

Death (before hospital discharge) or BPD (supplemental oxygen/respiratory support at 36 weeks' postmenstrual age if born < 32 weeks' gestation, or 28 days if born ≥ 32 weeks' gestation) · preterm infants requiring primary respiratory support

It is very uncertain whether nasal high flow changes death (before hospital discharge) or BPD (supplemental… compared with nasal intermittent positive pressure ventilation (very low certainty).

1 finding from 1 review

HFNC vs continuous positive airway pressure (CPAP)

Duration of any form of respiratory support (any form of non‐invasive respiratory support with or without supplemental oxygen) · respiratory support in term infants (infants ≥ 37 weeks gestational age to the end of the neonatal period (up to 1 month postnatal age))
1 finding from 1 review

Non‐invasive ventilation vs supplemental oxygen or no treatment

Need for mechanical ventilation · patients with the management of transient tachypnea of the newborn

It is very uncertain whether non‐invasive respiratory support changes need for mechanical ventilation compared with supplemental oxygen or no treatment (very low certainty).

1 finding from 1 review

Non‐invasive ventilation vs supplemental oxygen or no treatment

All‐cause mortality · patients with the management of transient tachypnea of the newborn

It is very uncertain whether non‐invasive respiratory support changes all‐cause mortality compared with supplemental oxygen or no treatment (very low certainty).

1 finding from 1 review

Inhaled NO vs control

Neurodevelopmental disability · respiratory failure in preterm infants

Inhaled NO showed no clear difference in neurodevelopmental disability ‐ Studies of routine use in preterm… compared with control (high certainty).

1 finding from 1 review

Inhaled NO vs control

Mortality before hospital discharge · respiratory failure in preterm infants

Inhaled NO showed no clear difference in death before discharge ‐ Studies of routine use in preterm infants… compared with control (moderate certainty).

1 finding from 1 review

Inhaled NO vs control

Death or bronchopulmonary dysplasia · respiratory failure in preterm infants

Inhaled NO showed no clear difference in death or bronchopulmonary dysplasia at 36 weeks ‐ Studies of routine… compared with control (high certainty).

1 finding from 1 review