Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

24 questions · 24 findings · 3 reviews · ENT · Headline outcomes only

No studies found 9 · 37.5%GRADE not reported 0 · 0%Very low 7 · 29.2%Low 5 · 20.8%Moderate 3 · 12.5%High 0 · 0%

Antibiotics vs no treatment or placebo on top of topical antibiotics

Resolution of ear discharge ‐ measured after 4 weeks · people with CSOM; one study included patients of unknown age; one study included children with CSOM who had not responded to initial…

It is very uncertain whether systemic antibiotics changes resolution of ear discharge ‐ measured after 4 weeks (6 weeks) (Oral… compared with no treatment or placebo on top of topical antibiotics (very low certainty).

1 finding from 1 review

Antibiotic eardrops (with or without a corticosteroid) vs oral antibiotics

Resolution of ear discharge at short‐term

Antibiotic eardrops (with or without a corticosteroid) probably leads to higher resolution of ear discharge at short‐term compared with oral antibiotics (moderate certainty).

1 finding from 1 review

Antibiotic eardrops (with or without a corticosteroid) vs oral antibiotics

Resolution of ear discharge at intermediate‐term

Antibiotic eardrops (with or without a corticosteroid) probably leads to higher resolution of ear discharge at intermediate‐term compared with oral antibiotics (moderate certainty).

1 finding from 1 review

Topical quinolone vs oral amoxicillin‐clavulanic acid combination

Resolution of ear discharge ‐ measured at 1 to 2 weeks · adults with CSOM

It is very uncertain whether topical quinolone changes resolution of ear discharge ‐ 1 to 2 weeks compared with oral amoxicillin‐clavulanic acid combination (very low certainty).

1 finding from 1 review