Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

47 questions · 52 findings · 10 reviews · Drugs and Alcohol

No studies found 1 · 1.9%GRADE not reported 0 · 0%Very low 3 · 5.8%Low 28 · 53.8%Moderate 13 · 25%High 7 · 13.5%

Pharmacological detoxification treatment vs other pharmacological detoxification treatment

Completion of treatment · management of opium withdrawal

Pharmacological detoxification treatment may leads to higher completion of treatment: clonidine versus methadone compared with other pharmacological detoxification treatment (low certainty).

3 findings from 1 review

Pharmacological detoxification treatment vs other pharmacological detoxification treatment

Completion of treatment: methadone versus methadone plus gabapentin · management of opium withdrawal

Pharmacological detoxification treatment showed no clear difference in completion of treatment: methadone versus methadone plus gabapentin compared with other pharmacological detoxification treatment (low certainty).

1 finding from 1 review

Intervention not reported

Retained in naltrexone maintenance treatment or abstinent at 12 weeks ‐ Tapered methadone comparison · patients with opioid withdrawal

The intervention showed no clear difference in retained in naltrexone maintenance treatment or abstinent at 12… (low certainty).

1 finding from 1 review