Frequency of crisis · sickle cell disease
L‐arginine showed no clear difference in frequency of crisis (monthly crisis) compared with placebo (low certainty).
1 finding from 1 review
Pain 0 to 100 visual analogue scale and 10‐point Likert scale (lower score = less pain) · sickle cell disease
L‐arginine showed no clear difference in severity of pain (assessed using a 10‐cm visual analogue scale from… compared with placebo (low certainty).
1 finding from 1 review
QoL of participants living with SCD and their caregivers · sickle cell disease
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse effects · sickle cell disease
1 finding from 1 review
Frequency of hospitalization (number of days in hospital) · sickle cell disease
It is very uncertain whether L‐arginine changes frequency of hospitalization (number of days in hospital) compared with placebo (very low certainty).
1 finding from 1 review
Frequency of sickle cell‐related complications · sickle cell disease
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Haemoglobin status · sickle cell disease
L‐arginine showed no clear difference in haemoglobin status (g/dL) compared with placebo (low certainty).
1 finding from 1 review
L‐arginine salve 0 to 3 severity score · uraemic pruritus
1 finding from 1 review
Death or dependency · people with acute stroke
Glyceryl trinitrate (GTN) showed no clear difference in death or dependency (mRS>2), end of trial (90 days) compared with no GTN (high certainty).
1 finding from 1 review
Death by end of trial · people with acute stroke
Glyceryl trinitrate (GTN) showed no clear difference in death, end of trial (90 days) compared with no GTN (high certainty).
1 finding from 1 review
Quality of life, end of trial (90 days) · people with acute stroke
1 finding from 1 review
Systolic blood pressure · people with acute stroke
1 finding from 1 review
Diastolic blood pressure · people with acute stroke
1 finding from 1 review
Heart rate · people with acute stroke
1 finding from 1 review
Adverse effects: headache · people with acute stroke
Glyceryl trinitrate (GTN) leads to higher adverse event: Headache, on treatment (7‐12 days) compared with no GTN (high certainty).
1 finding from 1 review