Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

63 questions · 63 findings · 9 reviews · Neonatal

No studies found 10 · 15.9%GRADE not reported 2 · 3.2%Very low 13 · 20.6%Low 22 · 34.9%Moderate 16 · 25.4%High 0 · 0%

Intravenous fluid supplementation vs no fluid supplementation

Proportion of infants who required exchange transfusion · newborn infants with unconjugated hyperbilirubinaemia undergoing phototherapy

Intravenous fluid supplementation may leads to lower proportion of infants who required exchange transfusion compared with no fluid supplementation (low certainty).

1 finding from 1 review

Intravenous immunoglobulin plus phototherapy vs phototherapy alone

Use of ET (≥ 1); placebo‐controlled studies · neonates with alloimmune hemolytic disease

Intravenous immunoglobulin plus phototherapy showed no clear difference in use of ET (≥ 1); placebo‐controlled studies compared with phototherapy alone (moderate certainty).

1 finding from 1 review

Intravenous immunoglobulin plus phototherapy vs phototherapy alone

Use of top‐up transfusion in 1st week of life; all studies · neonates with alloimmune hemolytic disease

Intravenous immunoglobulin plus phototherapy showed no clear difference in use of top‐up transfusion in 1st week of life; all studies compared with phototherapy alone (low certainty).

1 finding from 1 review

Intravenous immunoglobulin plus phototherapy vs phototherapy alone

Use of top‐up transfusion after 1st week of life; all studies · neonates with alloimmune hemolytic disease

It is very uncertain whether intravenous immunoglobulin plus phototherapy changes use of top‐up transfusion after 1st week of life; all studies compared with phototherapy alone (very low certainty).

1 finding from 1 review

Dextrose gel vs placebo

Receipt of treatment for hypoglycaemia during initial hospital stay (investigator‐defined, any treatment ‐ oral dextrose gel, intravenous dextrose, or other drug therapy) during initial hospital stay (yes/no) · newborn infants at risk of neonatal hypoglycaemia

Dextrose gel showed no clear difference in receipt of treatment for hypoglycaemia during initial hospital stay… compared with placebo (moderate certainty).

1 finding from 1 review