Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

27 questions · 27 findings · 6 reviews · Haematology

No studies found 4 · 14.8%GRADE not reported 4 · 14.8%Very low 14 · 51.9%Low 0 · 0%Moderate 5 · 18.5%High 0 · 0%

Vitamin K antagonists vs low molecular weight heparin

Minor bleeding · ambulatory patients with multiple myeloma receiving immunomodulatory agents

It is very uncertain whether vitamin K antagonist (VKA) changes minor bleeding compared with low molecular weight heparin (LMWH) (very low certainty).

1 finding from 1 review

Prophylactic platelet transfusion prior to surgery vs alternative treatment

Number of participants with minor procedure‐related bleeding within 7 days of surgery · people with a low platelet count

It is very uncertain whether prophylactic platelet transfusion prior to surgery changes number of participants with minor procedure‐related bleeding within… compared with alternative treatments (very low certainty).

1 finding from 1 review

Prophylactic platelet transfusion prior to surgery vs no prophylactic platelet transfusion prior to surgery

Number of participants with minor procedure‐related bleeding within 7 days of surgery · people with a low platelet count

It is very uncertain whether prophylactic platelet transfusion prior to surgery changes the number of participants with minor procedure‐related bleeding… compared with no prophylactic platelet transfusion prior to surgery (very low certainty).

1 finding from 1 review

Comparison of plasma transfusions vs no plasma transfusions when the INR is 1.5 prior to central venous catheter insertion

Number of participants with minor procedure‐related bleeding within 7 days of surgery · people with abnormal coagulation requiring a central venous catheter

It is very uncertain whether comparison of plasma transfusions changes minor procedure‐related bleeding compared with no plasma transfusions when the INR is 1.5 prior to central venous… (very low certainty).

1 finding from 1 review

ATRA in addition to chemotherapy vs chemotherapy alone

Mortality (calculated instead of overall survival) · adults with acute myeloid leukaemia (AML) (non‐acute promyelocytic leukaemia (APL))

ATRA in addition to chemotherapy showed no clear difference in mortality (instead of overall survival) compared with chemotherapy only (moderate certainty).

1 finding from 1 review