Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

123 questions · 135 findings · 11 reviews · Pregnancy and Childbirth

No studies found 23 · 17%GRADE not reported 9 · 6.7%Very low 50 · 37%Low 41 · 30.4%Moderate 9 · 6.7%High 3 · 2.2%

Combined spinal‐epidural vs high‐dose spinal

Number of women requiring intra‐operative conversion to general anaesthesia · women undergoing caesarean section

It is very uncertain whether combined spinal‐epidural changes number of women requiring intra‐operative conversion to general… compared with high‐dose spinal (very low certainty).

1 finding from 1 review

Anti‐D administration in pregnancy vs no treatment

Incidence of Rhesus D alloimmunisation during pregnancy · Rh‐negative women without anti‐D antibodies

Anti‐D administration in pregnancy showed no clear difference in incidence of Rhesus D alloimmunisation during pregnancy compared with no treatment (low certainty).

1 finding from 1 review

Anti‐D administration in pregnancy vs no treatment

Incidence of Rhesus D alloimmunisation postpartum (at birth of Rh‐positive infant and at · Rh‐negative women without anti‐D antibodies

Anti‐D administration in pregnancy showed no clear difference in incidence of Rhesus D alloimmunisation postpartum (at birth of… compared with no treatment (low certainty).

1 finding from 1 review

Pyridoxine vs placebo

Adverse effects: headache · Pregnant women with hyperemesis gravidarum

Pyridoxine showed no clear difference in interventions side effects: headaches compared with placebo (low certainty).

1 finding from 1 review

5‐HT3 antagonists vs placebo

Nausea · women undergoing regional anaesthesia for caesarean section

5‐HT3 antagonists may leads to lower nausea ‐ intraoperative compared with placebo (low certainty).

2 findings from 1 review

Corticosteroids vs placebo

Nausea · women undergoing regional anaesthesia for caesarean section

Corticosteroids probably leads to lower nausea ‐ postoperative compared with placebo (moderate certainty).

2 findings from 1 review