Cochrane · systematic review · CD007579
Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section
Griffiths, JD, Gyte, GML, Popham, PA, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
36
current version
GRADE rated
33
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 3 · 8.3%Very low 17 · 47.2%Low 12 · 33.3%Moderate 4 · 11.1%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
5‐HT3 antagonists compared to placebo for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section
Population: women undergoing regional anaesthesia for caesarean section
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Nausea ‐ intraoperative 5‐HT3 antagonists vs placebo | RR 0.55 [0.42, 0.71] | 12 studies · 1419 participants | Low Downgraded: risk of bias |
Vomiting ‐ intraoperative 5‐HT3 antagonists vs placebo | RR 0.46 [0.29, 0.73] | 11 studies · 1414 participants | Very low Downgraded: risk of bias, inconsistency, publication bias |
Nausea ‐ postoperative 5‐HT3 antagonists vs placebo | RR 0.4 [0.3, 0.54] | 10 studies · 1340 participants | Moderate Downgraded: risk of bias, inconsistency, publication bias |
Vomiting ‐ postoperative 5‐HT3 antagonists vs placebo | RR 0.47 [0.31, 0.69] | 10 studies · 1450 participants | Low Downgraded: risk of bias, inconsistency, publication bias |
Dopamine antagonists compared to placebo for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section
Population: women undergoing regional anaesthesia for caesarean section
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Nausea ‐ intraoperative Dopamine antagonists vs placebo | RR 0.38 [0.27, 0.52] | 15 studies · 1180 participants | Very low Downgraded: risk of bias |
Vomiting ‐ intraoperative Dopamine antagonists vs placebo | RR 0.41 [0.28, 0.6] | 12 studies · 942 participants | Low Downgraded: risk of bias |
Nausea ‐ postoperative Dopamine antagonists vs placebo | RR 0.61 [0.48, 0.79] | 7 studies · 601 participants | Low Downgraded: risk of bias |
Vomiting ‐ postoperative Dopamine antagonists vs placebo | RR 0.63 [0.44, 0.92] | 9 studies · 860 participants | Very low Downgraded: risk of bias |
Corticosteroids compared to placebo for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section
Population: women undergoing regional anaesthesia for caesarean section
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Nausea ‐ intraoperative Corticosteroids vs placebo | RR 0.56 [0.37, 0.83] | 6 studies · 609 participants | Very low Downgraded: risk of bias |
Vomiting ‐ intraoperative Corticosteroids vs placebo | RR 0.52 [0.31, 0.87] | 6 studies · 609 participants | Very low Downgraded: risk of bias |
Nausea ‐ postoperative Corticosteroids vs placebo | RR 0.59 [0.49, 0.73] | 6 studies · 733 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Vomiting ‐ postoperative Corticosteroids vs placebo | RR 0.68 [0.49, 0.95] | 7 studies · 793 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Antihistamines compared to placebo for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section
Population: preventing nausea and vomiting
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Nausea ‐ intraoperative Antihistamines vs placebo | RR 0.99 [0.47, 2.11] | 1 study · 149 participants | Very low Downgraded: risk of bias, imprecision |
Vomiting ‐ intraoperative Antihistamines vs placebo | no estimate extracted | 1 study · 149 participants | Very low Downgraded: risk of bias, imprecision |
Nausea ‐ postoperative Antihistamines vs placebo | RR 0.44 [0.3, 0.64] | 4 studies · 514 participants | Low Downgraded: risk of bias, imprecision |
Vomiting ‐ postoperative Antihistamines vs placebo | RR 0.48 [0.29, 0.81] | 3 studies · 333 participants | Very low Downgraded: risk of bias, imprecision |
Anticholinergics compared to placebo for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section
Population: women undergoing regional anaesthesia for caesarean section
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Nausea ‐ intraoperative Anticholinergics vs placebo | RR 0.67 [0.51, 0.87] | 4 studies · 453 participants | Low Downgraded: risk of bias |
Vomiting ‐ intraoperative Anticholinergics vs placebo | RR 0.79 [0.4, 1.54] | 4 studies · 453 participants | Very low Downgraded: risk of bias |
Nausea ‐ postoperative Anticholinergics vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Vomiting ‐ postoperative Anticholinergics vs placebo | RR 0.55 [0.41, 0.74] | 1 study · 161 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Sedatives compared to placebo for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section
Population: women undergoing regional anaesthesia for caesarean section
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Nausea ‐ intraoperative Sedatives vs placebo | RR 0.65 [0.51, 0.82] | 8 studies · 593 participants | Moderate Downgraded: risk of bias |
Vomiting ‐ intraoperative Sedatives vs placebo | RR 0.35 [0.24, 0.52] | 8 studies · 593 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Nausea ‐ postoperative Sedatives vs placebo | RR 0.25 [0.09, 0.71] | 2 studies · 145 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Vomiting ‐ postoperative Sedatives vs placebo | RR 0.09 [0.03, 0.28] | 2 studies · 145 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Opioid antagonists compared to placebo for preventing nausea and vomiting
Population: preventing nausea and vomiting
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Nausea ‐ intraoperative Opioid antagonists vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Vomiting ‐ intraoperative Opioid antagonists vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Nausea ‐ postoperative Opioid antagonists vs placebo | RR 0.75 [0.39, 1.45] | 1 study · 120 participants | Low Downgraded: imprecision |
Vomiting ‐ postoperative Opioid antagonists vs placebo | RR 1.25 [0.35, 4.43] | 1 study · 120 participants | Low Downgraded: imprecision |
Acupressure/acupuncture compared to placebo for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section
Population: women undergoing regional anaesthesia for caesarean section
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Nausea ‐ intraoperative Acupressure/acupuncture vs placebo | RR 0.55 [0.41, 0.74] | 9 studies · 1221 participants | Very low Downgraded: risk of bias |
Vomiting ‐ intraoperative Acupressure/acupuncture vs placebo | RR 0.52 [0.33, 0.8] | 9 studies · 1221 participants | Low Downgraded: risk of bias |
Nausea ‐ postoperative Acupressure/acupuncture vs placebo | RR 0.46 [0.27, 0.75] | 7 studies · 1069 participants | Very low Downgraded: risk of bias |
Vomiting ‐ postoperative Acupressure/acupuncture vs placebo | RR 0.52 [0.34, 0.79] | 7 studies · 1069 participants | Very low Downgraded: risk of bias |
Ginger compared to placebo for preventing nausea and vomiting
Population: preventing nausea and vomiting
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Nausea ‐ intraoperative Ginger vs placebo | RR 0.66 [0.36, 1.21] | 2 studies · 331 participants | Very low Downgraded: risk of bias |
Vomiting ‐ intraoperative Ginger vs placebo | RR 0.62 [0.38, 1] | 2 studies · 331 participants | Very low Downgraded: risk of bias |
Nausea ‐ postoperative Ginger vs placebo | RR 0.63 [0.22, 1.77] | 1 study · 92 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Vomiting ‐ postoperative Ginger vs placebo | RR 0.2 [0.02, 1.65] | 1 study · 92 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |