Seizure control Seizure recurrence · people with neurocysticercosis
Short‐duration antiepileptic drug treatment showed no clear difference in seizure control(seizure recurrence) compared with long‐duration antiepileptic drug treatment (low certainty).
1 finding from 1 review
Seizure control Seizure recurrence · people with neurocysticercosis
It is very uncertain whether six‐ to 12‐month antiepileptic drug treatment changes seizure control (seizure recurrence) compared with 24‐month antiepileptic drug treatment (very low certainty).
1 finding from 1 review
Adverse events (control ‐ deferred treatment) · patients with first unprovoked seizure
Immediate treatment probably leads to higher adverse events (control ‐ deferred treatment) compared with controls (moderate certainty).
1 finding from 1 review
Adverse events (control ‐ no treatment) · patients with first unprovoked seizure
Immediate treatment may leads to higher adverse events (control ‐ no treatment) compared with controls (low certainty).
1 finding from 1 review
Any serious adverse event of treatment · people with traumatic head injuries
1 finding from 1 review
Any serious adverse event of treatment count of events · people with traumatic head injuries
Antiepileptic drugs showed no clear difference in any serious adverse event of treatment count of events compared with placebo or standard care (low certainty).
1 finding from 1 review
Post‐treatment quality of life (QOLIE‐31 score, which has a range of 0‐200, with higher score indicates better quality of life) ( · people with epilepsy
1 finding from 1 review
Seizure recurrence at 5 years after randomisation · patients with first unprovoked seizure
Immediate treatment leads to lower seizure recurrence at 5 years after randomisation compared with controls (high certainty).
1 finding from 1 review
Five year immediate remission after randomisation · patients with first unprovoked seizure
Immediate treatment leads to higher five‐year immediate remission after randomisation compared with controls (high certainty).
1 finding from 1 review
Five year remission at any time after randomisation · patients with first unprovoked seizure
Immediate treatment showed no clear difference in five‐year remission at any time after randomisation compared with controls (high certainty).
1 finding from 1 review
Seizure recurrence at 1 year after randomisation · patients with first unprovoked seizure
Immediate treatment leads to lower seizure recurrence at 1 year after randomisation compared with controls (high certainty).
1 finding from 1 review
Mortality at the end of the · patients with first unprovoked seizure
Immediate treatment showed no clear difference in mortality at the end of the compared with controls (high certainty).
1 finding from 1 review
Adverse events (control ‐ placebo) · patients with first unprovoked seizure
Immediate treatment probably leads to higher adverse events (control ‐ placebo) compared with controls (moderate certainty).
1 finding from 1 review
Treatment withdrawalNumber of participants withdrawn for any reason · people with drug‐resistant focal epilepsy
Gabapentin showed no clear difference in treatment withdrawalNumber of participants withdrawn for any reason compared with placebo (moderate certainty).
1 finding from 1 review
Early seizures (number of seizures) · people with traumatic head injuries
Anti‐epileptic drugs showed no clear difference in early seizure Counts of events compared with other anti‐epileptic drugs (low certainty).
1 finding from 1 review
Late seizures (number of seizures) · people with traumatic head injuries
Anti‐epileptic drugs showed no clear difference in late seizure Counts of events compared with other anti‐epileptic drugs (moderate certainty).
1 finding from 1 review
All‐cause mortality · people with traumatic head injuries
Anti‐epileptic drugs showed no clear difference in all‐cause mortality compared with other anti‐epileptic drugs (moderate certainty).
1 finding from 1 review
Seizures · people with traumatic head injuries
1 finding from 1 review
Treatment withdrawal · people with drug‐resistant focal epilepsy
Summary of findings: lamotrigine showed no clear difference in treatment withdrawal compared with placebo (moderate certainty).
1 finding from 1 review
Acceptability ‐ total dropouts · people (aged 12 years and over) with drug‐resistant focal epilepsy
Perampanel add‐on may leads to higher treatment withdrawal due to any reason compared with placebo (low certainty).
1 finding from 1 review