Cochrane · systematic review · CD009900
Pharmacological treatments for preventing epilepsy following traumatic head injury
Thompson, K, Pohlmann‐Eden, B, Campbell, LA, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
EpilepsyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
15
current version
GRADE rated
10
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 5 · 33.3%Very low 2 · 13.3%Low 4 · 26.7%Moderate 2 · 13.3%High 2 · 13.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Antiepileptic drugs compared with placebo or standard care for people at risk of epilepsy following traumatic head injury
Population: people with traumatic head injuries
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Early seizures Count of events Antiepileptic drugs vs placebo or standard care | RR 0.42 [0.23, 0.74] | 5 studies · 987 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Late seizures Count of events Antiepileptic drugs vs placebo or standard care | RR 0.91 [0.57, 1.46] | 6 studies · 1029 participants | Very low Downgraded: risk of bias, inconsistency |
All‐cause mortality Antiepileptic drugs vs placebo or standard care | RR 1.08 [0.79, 1.46] | 5 studies · 1065 participants | Very low Downgraded: risk of bias, inconsistency |
Any serious adverse event of treatment count of events Antiepileptic drugs vs placebo or standard care | RR 1.63 [0.73, 3.66] | 2 studies · 568 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Time to first seizure from randomization Antiepileptic drugs vs placebo or standard care | no estimate extracted | 0 studies · 0 participants | Ungraded |
Neuroprotective agent versus placebo for people at risk of epilepsy following traumatic head injury
Population: people with traumatic head injuries
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Early seizure Count of events Neuroprotective agent vs placebo | RR 2.99 [0.12, 73] | 1 study · 499 participants | Low Downgraded: risk of bias |
Late seizure Count of events Neuroprotective agent vs placebo | RR 1.07 [0.53, 2.17] | 1 study · 498 participants | High |
All‐cause mortality Neuroprotective agent vs placebo | RR 1.2 [0.8, 1.81] | 1 study · 466 participants | High |
Any serious adverse event of treatment Neuroprotective agent vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Time to first seizure from randomization Neuroprotective agent vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Anti‐epileptic drugs compared to other anti‐epileptic drugs for people at risk of epilepsy following traumatic head injury
Population: people with traumatic head injuries
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Early seizure Counts of events Anti‐epileptic drugs vs other anti‐epileptic drugs | RR 0.66 [0.2, 2.12] | 2 studies · 431 participants | Low Downgraded: risk of bias, imprecision |
Late seizure Counts of events Anti‐epileptic drugs vs other anti‐epileptic drugs | RR 0.77 [0.46, 1.3] | 2 studies · 378 participants | Moderate Downgraded: risk of bias, imprecision |
All‐cause mortality Anti‐epileptic drugs vs other anti‐epileptic drugs | RR 0.53 [0.3, 94] | 2 studies · 431 participants | Moderate Downgraded: risk of bias, imprecision |
Any serious adverse event of treatment Anti‐epileptic drugs vs other anti‐epileptic drugs | no estimate extracted | 0 studies · 0 participants | Ungraded |
Time to first seizure from randomization Anti‐epileptic drugs vs other anti‐epileptic drugs | no estimate extracted | 0 studies · 0 participants | Ungraded |