Findings

What do systematic reviews say?

52 questions · 52 findings · 8 reviews

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No studies found 14 · 26.9%GRADE not reported 10 · 19.2%Very low 14 · 26.9%Low 11 · 21.2%Moderate 2 · 3.8%High 1 · 1.9%

Closest answers

The findings closest to your search, judged one by one by TypeSafe's Jev model.

Direct match · question page
- Down syndrome (trisomy 21) vs Individuals without Down syndrome (healthy controls: siblings, schoolchildren or others) · Dental caries (presence vs absence; all teeth, deciduous and permanent)
  Association between Dental Caries and Down Syndrome: A Systematic Review and Meta-Analysis. 2015 All outcomes
  Individuals with and without Down syndrome in Portugal (reference centre, national database and closest-age siblings); cross-sectional studies
  OR 0.36 [0.22, 0.57]
  2 studies · 314 participants
  GRADE not reported
Direct match · question page
- Parent‐mediated intervention vs treatment · Expressive language (number of (different) target words)
  Parent‐mediated interventions for promoting communication and language development in young children with Down syndrome 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 12 participants
  Very low
Direct match · question page
- Down syndrome (trisomy 21) vs Individuals without Down syndrome (healthy controls: siblings, schoolchildren or others) · Dental caries experience (mean DMFT; permanent teeth)
  Association between Dental Caries and Down Syndrome: A Systematic Review and Meta-Analysis. 2015 All outcomes
  Individuals with and without Down syndrome from referral centres, national databases and schools across China, Portugal, Jordan, Nigeria, Brazil and India; cross-sectional studies
  SMD -0.18 [-0.35, -0.02]
  6 studies · 718 participants
  GRADE not reported
Direct match · question page
- Parent‐ and clinician‐mediated intervention vs clinician‐mediated intervention alone · Expressive language (number of words; standard scores; MLUw; NDW; IPSyn; frequency of unique targets; % target talk)
  Parent‐mediated interventions for promoting communication and language development in young children with Down syndrome 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 18 participants
  Very low
Direct match · question page
- Parent‐mediated intervention vs treatment · Receptive language (total language; standard scores)
  Parent‐mediated interventions for promoting communication and language development in young children with Down syndrome 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 15 participants
  Very low

Down syndrome vs Individuals without Down syndrome (healthy controls: siblings, schoolchildren or others)

Mean DMFT (decayed, missing, filled permanent teeth) · Individuals of all ages

Individuals with Down syndrome had a lower mean DMFT in permanent teeth than controls (pooled SMD -0.18, 95% CI -0.35 to -0.02; 6 studies; I2=20%); certainty of evidence not graded.

1 finding from 1 review

Association between Dental Caries and Down Syndrome: A Systematic Review and Meta-Analysis. 2015 All outcomes
Individuals with and without Down syndrome from referral centres, national databases and schools across China, Portugal, Jordan, Nigeria, Brazil and India; cross-sectional studies
SMD -0.18 [-0.35, -0.02]
6 studies · 718 participants
GRADE not reported

Down syndrome vs Individuals without Down syndrome (healthy controls: siblings, schoolchildren or others)

Dental caries · Individuals of all ages

Individuals with Down syndrome had a lower prevalence of dental caries than those without (pooled OR 0.36, 95% CI 0.22 to 0.57; 2 studies; I2=0%); certainty of evidence not graded.

1 finding from 1 review

Association between Dental Caries and Down Syndrome: A Systematic Review and Meta-Analysis. 2015 All outcomes
Individuals with and without Down syndrome in Portugal (reference centre, national database and closest-age siblings); cross-sectional studies
OR 0.36 [0.22, 0.57]
2 studies · 314 participants
GRADE not reported

Down syndrome vs Healthy controls

Gingivitis · Children with Down syndrome in Dubai

Gingivitis prevalence was 65.4% in children with Down syndrome versus 70.4% in controls.

1 finding from 1 review

Oral Health of Children and Adolescents in the United Arab Emirates: A Systematic Review of the Past Decade. 2021 All outcomes
Children with Down syndrome
Prevalence 65.4
1 study
GRADE not reported

Down syndrome vs Healthy controls

Dental caries prevalence · Children with Down syndrome in Dubai

Dental caries prevalence was 57.6% in children with Down syndrome and controls.

1 finding from 1 review

Oral Health of Children and Adolescents in the United Arab Emirates: A Systematic Review of the Past Decade. 2021 All outcomes
Children with Down syndrome
Prevalence 57.6
1 study
GRADE not reported

Down syndrome vs Healthy controls

Dental erosion prevalence · Children with Down syndrome in Dubai

Dental erosion prevalence was 34% in children with Down syndrome versus 15.3% in controls.

1 finding from 1 review

Oral Health of Children and Adolescents in the United Arab Emirates: A Systematic Review of the Past Decade. 2021 All outcomes
Children with Down syndrome
Prevalence 34
1 study
GRADE not reported

Down syndrome vs Healthy controls

Dental caries · Children with Down syndrome in Dubai

Mean DMFT was 2.73 in children with Down syndrome versus 1.65 in controls.

1 finding from 1 review

Oral Health of Children and Adolescents in the United Arab Emirates: A Systematic Review of the Past Decade. 2021 All outcomes
Children with Down syndrome
MEAN 2.73
1 study
GRADE not reported

Down syndrome (oral health status) vs Healthy controls

Oral health status (caries, DMFT, calculus, erosion, malocclusion, treatment indices) · Children with Down syndrome in Dubai

One study found children with Down syndrome had similar caries prevalence but higher DMFT, calculus, erosion and malocclusion than controls, with better restorative-care access (narrative synthesis; not GRADE-rated).

1 finding from 1 review

Oral Health of Children and Adolescents in the United Arab Emirates: A Systematic Review of the Past Decade. 2021 All outcomes
Dubai, UAE
Ghaith et al. (Dubai) reported dental decay in 57.6% of children with Down syndrome (same as controls) but a higher mean DMFT (2.73 vs 1.65) and calculus index (0.25 vs 0.07), higher erosion prevalence/severity, and…
1 study
GRADE not reported

Parent‐mediated intervention vs treatment

Expressive language (number of (different) target words) · children with Down syndrome aged between birth and six years

1 finding from 1 review

Parent‐mediated interventions for promoting communication and language development in young children with Down syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 12 participants
Very low

Parent‐ and clinician‐mediated intervention vs clinician‐mediated intervention alone

Parental stress · children with Down syndrome aged between birth and six years

1 finding from 1 review

Parent‐mediated interventions for promoting communication and language development in young children with Down syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 18 participants
Very low

Parent‐ and clinician‐mediated intervention vs clinician‐mediated intervention alone

Changes in parental behaviour/responsivity · children with Down syndrome aged between birth and six years

1 finding from 1 review

Parent‐mediated interventions for promoting communication and language development in young children with Down syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 18 participants
Very low

Parent‐ and clinician‐mediated intervention vs clinician‐mediated intervention alone

Socialisation · children with Down syndrome aged between birth and six years

The review found no eligible studies for this question.

1 finding from 1 review

Parent‐mediated interventions for promoting communication and language development in young children with Down syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Parent‐ and clinician‐mediated intervention vs clinician‐mediated intervention alone

Language attrition · children with Down syndrome aged between birth and six years

1 finding from 1 review

Parent‐mediated interventions for promoting communication and language development in young children with Down syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 18 participants
Very low

Parent‐ and clinician‐mediated intervention vs clinician‐mediated intervention alone

Adherence · children with Down syndrome aged between birth and six years

The review found no eligible studies for this question.

1 finding from 1 review

Parent‐mediated interventions for promoting communication and language development in young children with Down syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Parent‐mediated intervention vs treatment

Receptive language (total language; standard scores) · children with Down syndrome aged between birth and six years

1 finding from 1 review

Parent‐mediated interventions for promoting communication and language development in young children with Down syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 15 participants
Very low

Parent‐mediated intervention vs treatment

Parental stress · children with Down syndrome aged between birth and six years

The review found no eligible studies for this question.

1 finding from 1 review

Parent‐mediated interventions for promoting communication and language development in young children with Down syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Parent‐mediated intervention vs treatment

Changes in parental behaviour/responsivity · children with Down syndrome aged between birth and six years

1 finding from 1 review

Parent‐mediated interventions for promoting communication and language development in young children with Down syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 27 participants
Very low

Parent‐mediated intervention vs treatment

Socialisation · children with Down syndrome aged between birth and six years

1 finding from 1 review

Parent‐mediated interventions for promoting communication and language development in young children with Down syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 15 participants
Very low

Parent‐mediated intervention vs treatment

Language attrition · children with Down syndrome aged between birth and six years

1 finding from 1 review

Parent‐mediated interventions for promoting communication and language development in young children with Down syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 27 participants
Very low

Parent‐mediated intervention vs treatment

Adherence · children with Down syndrome aged between birth and six years

1 finding from 1 review

Parent‐mediated interventions for promoting communication and language development in young children with Down syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 12 participants
Very low

Parent‐ and clinician‐mediated intervention vs clinician‐mediated intervention alone

Expressive language (number of words; standard scores; MLUw; NDW; IPSyn; frequency of unique targets; % target talk) · children with Down syndrome aged between birth and six years

1 finding from 1 review

Parent‐mediated interventions for promoting communication and language development in young children with Down syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 18 participants
Very low