Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

37 questions · 37 findings · 5 reviews · Headline outcomes only

No studies found 7 · 18.9%GRADE not reported 1 · 2.7%Very low 9 · 24.3%Low 12 · 32.4%Moderate 6 · 16.2%High 2 · 5.4%

Dexmedetomidine vs control or placebo medications

Adverse event nausea and vomiting (0 to 24 hours) · adults undergoing brain surgery

Dexmedetomidine showed no clear difference in adverse event nausea and vomiting (0 to 24 hours) compared with control or placebo medications (low certainty).

1 finding from 1 review

Dexmedetomidine vs traditional sedative agents

Risk of delirium · Critically ill patients requiring long‐term sedation during mechanical ventilation

It is very uncertain whether dexmedetomidine changes risk of delirium compared with traditional sedative agents (very low certainty).

1 finding from 1 review

Dexmedetomidine vs traditional sedative agents

Bradycardia · Critically ill patients requiring long‐term sedation during mechanical ventilation

It is very uncertain whether dexmedetomidine changes incidence of bradycardia compared with traditional sedative agents (very low certainty).

1 finding from 1 review

Dexmedetomidine vs traditional sedative agents

All‐cause mortality · Critically ill patients requiring long‐term sedation during mechanical ventilation

It is very uncertain whether dexmedetomidine changes mortality compared with traditional sedative agents (very low certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg or 100 mg/kg) vs dexmedetomidine oral (2 µg/kg or 3 µg/kg)

Proportion of children who successfully completed neurodiagnostic procedure without interruption by the child awakening · children undergoing neurodiagnostic procedures

The review found no eligible studies for this question.

1 finding from 1 review