Dexmedetomidine vs traditional sedative agents: Bradycardia
It is very uncertain whether dexmedetomidine changes incidence of bradycardia compared with traditional sedative agents (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Dexmedetomidine vs traditional sedative agents Incidence of bradycardia · Critically ill patients requiring long‐term sedation during mechanical ventilation It is very uncertain whether dexmedetomidine changes incidence of bradycardia compared with traditional sedative agents (very low certainty). Alpha‐2 agonists for long‐term sedation during mechanical ventilation in critically ill patients (2015) · Cochrane Headline outcomes only | RR 2.11 [1.39, 3.2] | 6 studies · 1587 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Alpha‐2 agonists for long‐term sedation during mechanical ventilation in critically ill patients 2015 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.