Cochrane · systematic review · CD010269
Alpha‐2 agonists for long‐term sedation during mechanical ventilation in critically ill patients
Chen, K, Lu, Z, Xin, YC, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Emergency and Critical CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 14.3%Very low 5 · 71.4%Low 1 · 14.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Dexmedetomidine compared to traditional sedative agents for long‐term sedation during mechanical ventilation in critically ill patients
Population: Critically ill patients requiring long‐term sedation during mechanical ventilation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Duration of mechanical ventilation Dexmedetomidine vs traditional sedative agents | no estimate extracted | 4 studies · 1120 participants | Low Downgraded: risk of bias |
Risk of delirium Dexmedetomidine vs traditional sedative agents | RR 0.85 [0.63, 1.14] | 7 studies · 1624 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Risk of coma Dexmedetomidine vs traditional sedative agents | RR 0.69 [0.55, 0.86] | 1 study · 103 participants | Very low Downgraded: risk of bias |
Incidence of bradycardia Dexmedetomidine vs traditional sedative agents | RR 2.11 [1.39, 3.2] | 6 studies · 1587 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Duration of weaning Dexmedetomidine vs traditional sedative agents | no estimate extracted | 1 study · 85 participants | Ungraded |
ICU length of stay Dexmedetomidine vs traditional sedative agents | no estimate extracted | 5 studies · 1223 participants | Very low Downgraded: risk of bias |
Mortality Dexmedetomidine vs traditional sedative agents | RR 0.99 [0.79, 1.24] | 6 studies · 1584 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, publication bias |