Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

44 questions · 50 findings · 20 reviews · Drugs and Alcohol · Headline outcomes only

No studies found 1 · 2%GRADE not reported 1 · 2%Very low 12 · 24%Low 20 · 40%Moderate 15 · 30%High 1 · 2%

Pharmacological detoxification treatment vs other pharmacological detoxification treatment

Withdrawal symptoms · management of opium withdrawal
4 findings from 1 review
Show 1 more finding

Baclofen vs placebo

Frequency of use % of heavy drinking days at the end of treatment · alcohol use disorder
1 finding from 1 review

Full or partial opioid agonist maintenance vs placebo, detoxification only or psychological treatment (buprenorphine maintenance compared to taper or treatment

Days of unsanctioned opioid use · pharmaceutical opioid dependent people

Full or partial opioid agonist maintenance showed no clear difference in days of unsanctioned opioid use (as number of days/30 or days/7) compared with placebo, detoxification only or psychological treatment… (low certainty).

1 finding from 1 review

Integrated CBT vs Twelve Step Facilitation

Percent of days abstinent · co‐occurring depression and substance use disorders
2 findings from 1 review