What do systematic reviews say?

Complex vs simplified health education

• Improving vaccination uptake among adolescents 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 17411 participants
  Moderate

Summary of findings table ‐ Prothrombin complex concentrates vs any comparator

It is very uncertain whether prothrombin complex concentrate changes overall mortality ‐ longest compared with any comparator (very low certainty).

• Prothrombin complex concentrate for reversal of vitamin K antagonist treatment in bleeding and non‐bleeding patients 2015 · Cochrane Headline outcomes only
  RR 0.93 [0.37, 2.33]
  3 studies · 421 participants
  Very low

Summary of findings table ‐ Prothrombin complex concentrates vs any comparator

It is very uncertain whether prothrombin complex concentrate changes number of new occurrences of RBC transfusion compared with any comparator (very low certainty).

• Prothrombin complex concentrate for reversal of vitamin K antagonist treatment in bleeding and non‐bleeding patients 2015 · Cochrane Headline outcomes only
  RR 1.08 [0.82, 1.43]
  2 studies · 376 participants
  Very low

Summary of findings table ‐ Prothrombin complex concentrates vs any comparator

It is very uncertain whether prothrombin complex concentrate changes number of complications probably related to the intervention compared with any comparator (very low certainty).

• Prothrombin complex concentrate for reversal of vitamin K antagonist treatment in bleeding and non‐bleeding patients 2015 · Cochrane Headline outcomes only
  RR 0.92 [0.78, 1.09]
  4 studies · 442 participants
  Very low

Summary of findings table ‐ Prothrombin complex concentrates vs any comparator

• Prothrombin complex concentrate for reversal of vitamin K antagonist treatment in bleeding and non‐bleeding patients 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 370 participants
  Very low

Information or education intervention as part of a complex intervention vs complex intervention without information or education

• Information or education interventions for adult intensive care unit (ICU) patients and their carers 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 175 participants
  Very low

Information or education intervention as part of a complex intervention vs complex intervention without information or education

The review found no eligible studies for this question.

• Information or education interventions for adult intensive care unit (ICU) patients and their carers 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Information or education intervention as part of a complex intervention vs complex intervention without information or education

• Information or education interventions for adult intensive care unit (ICU) patients and their carers 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 487 participants
  Very low

Information or education intervention as part of a complex intervention vs complex intervention without information or education

The review found no eligible studies for this question.

• Information or education interventions for adult intensive care unit (ICU) patients and their carers 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Information or education intervention as part of a complex intervention vs complex intervention without information or education

• Information or education interventions for adult intensive care unit (ICU) patients and their carers 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 59 participants
  Very low

Information or education intervention as part of a complex intervention vs complex intervention without information or education

• Information or education interventions for adult intensive care unit (ICU) patients and their carers 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 38 participants
  Very low

Information or education intervention as part of a complex intervention vs complex intervention without information or education

• Information or education interventions for adult intensive care unit (ICU) patients and their carers 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 38 participants
  Very low

Multivitamin vs control

• Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 5947 participants
  Low
• Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 2324 participants
  Low

Multivitamin vs control

The review found no eligible studies for this question.

• Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Complex information, support and training interventions vs inactive control (usual care care, attention control, waitlist)

• Remotely delivered information, training and support for informal caregivers of people with dementia 2021 · Cochrane Headline outcomes only
  no estimate extracted
  9 studies · 597 participants
  Moderate

Complex information, support and training interventions vs information only

Complex information, support and training interventions probably leads to higher dropouts for any reason compared with information provision only (moderate certainty).

• Remotely delivered information, training and support for informal caregivers of people with dementia 2021 · Cochrane Headline outcomes only
  RR 1.51 [1.04, 2.2]
  12 studies · 1266 participants
  Moderate

Complex information, support and training interventions vs information only

The review found no eligible studies for this question.

• Remotely delivered information, training and support for informal caregivers of people with dementia 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Complex information, support and training interventions vs information only

It is very uncertain whether complex information, support and training interventions changes institutional care ‐ nursing home placement compared with information provision only (very low certainty).

• Remotely delivered information, training and support for informal caregivers of people with dementia 2021 · Cochrane Headline outcomes only
  RR 2.67 [0.12, 60.93]
  1 study · 32 participants
  Very low

Complex information, support and training interventions vs inactive control (usual care care, attention control, waitlist)

• Remotely delivered information, training and support for informal caregivers of people with dementia 2021 · Cochrane Headline outcomes only
  no estimate extracted
  8 studies · 638 participants
  Moderate

Complex information, support and training interventions vs inactive control (usual care care, attention control, waitlist)

• Remotely delivered information, training and support for informal caregivers of people with dementia 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 311 participants
  Moderate