Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

21 questions · 22 findings · 5 reviews · Eyes and Vision

No studies found 4 · 18.2%GRADE not reported 0 · 0%Very low 4 · 18.2%Low 12 · 54.5%Moderate 1 · 4.5%High 1 · 4.5%

Combined surgery vs phacoemulsification alone

Proportion using one or more medications at one year after surgery Number of participants · patients with eyes with cataract and glaucoma

Combined surgery may leads to lower proportion using one or more medications at one year after surgery… compared with phacoemulsification alone (low certainty).

1 finding from 1 review

Combined surgery vs phacoemulsification alone

Mean change in medications Measured by number of bottles · patients with eyes with cataract and glaucoma

Combined surgery showed no clear difference in mean change in medications Measured by number of bottles compared with phacoemulsification alone (low certainty).

1 finding from 1 review

Combined surgery vs phacoemulsification alone

Need for additional surgery: proportion of participants who received additional surgery to control IOP at 1 year · patients with eyes with cataract and glaucoma

Combined surgery showed no clear difference in proportion who received re‐operation to control IOP within one year… compared with phacoemulsification alone (low certainty).

1 finding from 1 review

Combined surgery vs phacoemulsification alone

Proportion who received intervention for surgical complications within one year Number of participants · patients with eyes with cataract and glaucoma

Combined surgery showed no clear difference in proportion who received intervention for surgical complications… compared with phacoemulsification alone (low certainty).

1 finding from 1 review

Regular‐dose postoperative 5‐Fluorouracil vs control

Complications ‐ epithelial toxicity ‐ combined surgery · participants with glaucoma surgery

Regular‐dose postoperative 5‐Fluorouracil may leads to higher complications ‐ epithelial toxicity ‐ combined surgery compared with control (low certainty).

1 finding from 1 review

Combined trabeculotomy with trabeculectomy vs trabeculotomy

Proportion of participants with IOP≤ 21 mmHg, with or without ocular hypotensive medications 1 year · children at or before five years of age with primary congenital glaucoma

It is very uncertain whether combined trabeculotomy with trabeculectomy changes surgical success: proportion with postoperative IOP ≤ 21 mmHg with… compared with trabeculotomy (very low certainty).

1 finding from 1 review

Combined steroid and antibiotic therapy vs antibiotics alone

Complete resolution of endophthalmitis at 3 months' · eyes with acute endophthalmitis following an intraocular procedure (e.g. surgery, intravitreous injection)

It is very uncertain whether combined steroid and antibiotic therapy changes complete resolution of endophthalmitis at 3 months' compared with antibiotics alone (very low certainty).

1 finding from 1 review

Combined steroid and antibiotic therapy vs antibiotics alone

Visual acuity · eyes with acute endophthalmitis following an intraocular procedure (e.g. surgery, intravitreous injection)

Combined steroid and antibiotic therapy may leads to higher visual acuity 6/6 to 6/18 at 3 months' compared with antibiotics alone (low certainty).

2 findings from 1 review

Combined steroid and antibiotic therapy vs antibiotics alone

Adverse events at 3 to 12 months' · eyes with acute endophthalmitis following an intraocular procedure (e.g. surgery, intravitreous injection)

Combined steroid and antibiotic therapy showed no clear difference in adverse events at 3 to 12 months' compared with antibiotics alone (low certainty).

1 finding from 1 review