Cochrane · systematic review · CD008213
Surgical interventions for primary congenital glaucoma
Gagrani, M, Garg, I, Ghate, D · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
Eyes and VisionAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
9
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 5 · 55.6%Low 1 · 11.1%Moderate 3 · 33.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Combined trabeculotomy with trabeculectomy versus trabeculotomy for primary congenital glaucoma
Population: children at or before five years of age with primary congenital glaucoma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mean IOP (mmHg) Combined trabeculotomy with trabeculectomy vs trabeculotomy | no estimate extracted | 2 studies · 88 participants | Very low Downgraded: risk of bias, imprecision |
Surgical success: proportion with postoperative IOP ≤ 21 mmHg with or without glaucoma medications 1 year after surgery Combined trabeculotomy with trabeculectomy vs trabeculotomy | RR 1.01 [0.9, 1.14] | 3 studies · 102 participants | Very low Downgraded: risk of bias, imprecision |
Adverse outcomes Up to 3 years Combined trabeculotomy with trabeculectomy vs trabeculotomy | RR 0.73 [0.1, 5.43] | 3 studies · 102 participants | Very low Downgraded: imprecision, inconsistency |
Viscotrabeculotomy compared with conventional trabeculotomy for primary congenital glaucoma
Population: children at or before five years of age with primary congenital glaucoma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mean IOP 6 months after surgery Viscotrabeculotomy vs conventional trabeculotomy | no estimate extracted | 2 studies · 42 participants | Very low Downgraded: risk of bias, imprecision |
Proportion with postoperative IOP ≤ 21 mmHg (surgical success) with or without glaucoma medications 6 months after surgery Viscotrabeculotomy vs conventional trabeculotomy | RR 1.11 [0.7, 1.78] | 1 study · 41 participants | Very low Downgraded: risk of bias, imprecision |
Adverse outcomes—hyphema Up to 6 months after surgery Viscotrabeculotomy vs conventional trabeculotomy | RR 1.33 [0.63, 2.83] | 2 studies · 57 participants | Low Downgraded: imprecision |
Microcatheter‐assisted trabeculotomy compared with conventional trabeculotomy for primary congenital glaucoma
Population: children at or before five years of age with primary congenital glaucoma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mean IOP 1 year after surgery Microcatheter‐assisted trabeculotomy vs conventional trabeculotomy | no estimate extracted | 2 studies · 99 participants | Moderate Downgraded: imprecision |
Proportion with postoperative IOP ≤ 21 mmHg (surgical success) with or without glaucoma medications 1 year after surgery Microcatheter‐assisted trabeculotomy vs conventional trabeculotomy | RR 1.54 [1.2, 1.97] | 2 studies · 99 participants | Moderate Downgraded: imprecision |
Adverse outcomes— hyphema Up to 1 year after surgery Microcatheter‐assisted trabeculotomy vs conventional trabeculotomy | RR 2.25 [1.25, 4.04] | 2 studies · 102 participants | Moderate Downgraded: imprecision |