Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

64 questions · 66 findings · 13 reviews

No studies found 8 · 12.1%GRADE not reported 4 · 6.1%Very low 14 · 21.2%Low 29 · 43.9%Moderate 7 · 10.6%High 4 · 6.1%

Combined surgery vs phacoemulsification alone

Proportion using one or more medications at one year after surgery Number of participants · patients with eyes with cataract and glaucoma

Combined surgery may leads to lower proportion using one or more medications at one year after surgery… compared with phacoemulsification alone (low certainty).

1 finding from 1 review

Combined surgery vs phacoemulsification alone

Mean change in medications Measured by number of bottles · patients with eyes with cataract and glaucoma

Combined surgery showed no clear difference in mean change in medications Measured by number of bottles compared with phacoemulsification alone (low certainty).

1 finding from 1 review

Combined surgery vs phacoemulsification alone

Need for additional surgery: proportion of participants who received additional surgery to control IOP at 1 year · patients with eyes with cataract and glaucoma

Combined surgery showed no clear difference in proportion who received re‐operation to control IOP within one year… compared with phacoemulsification alone (low certainty).

1 finding from 1 review

Combined surgery vs phacoemulsification alone

Proportion who received intervention for surgical complications within one year Number of participants · patients with eyes with cataract and glaucoma

Combined surgery showed no clear difference in proportion who received intervention for surgical complications… compared with phacoemulsification alone (low certainty).

1 finding from 1 review

Regular‐dose postoperative 5‐Fluorouracil vs control

Complications ‐ epithelial toxicity ‐ combined surgery · participants with glaucoma surgery

Regular‐dose postoperative 5‐Fluorouracil may leads to higher complications ‐ epithelial toxicity ‐ combined surgery compared with control (low certainty).

1 finding from 1 review

Combined oral and intravenous vs oral or intravenous alone

Wound infection · colorectal surgery

Combined oral and intravenous leads to lower surgical wound infection: oral + iv versus iv alone compared with oral or intravenous alone (high certainty).

2 findings from 1 review

Summary of findings table ‐ Combined mechanical and oral antibiotic bowel preparation vs mechanical bowel preparation alone

Surgical site infection · Patients undergoing elective colorectal surgery

Summary of findings table ‐ Combined mechanical and oral antibiotic… probably leads to lower SSI compared with mechanical bowel preparation alone (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Combined mechanical and oral antibiotic bowel preparation vs no bowel preparation

Surgical site infection · Patients undergoing elective colorectal surgery

Summary of findings table ‐ Combined mechanical and oral antibiotic… showed no clear difference in surgical site infections compared with no bowel preparation (low certainty).

1 finding from 1 review

Summary of findings table ‐ Combined mechanical and oral antibiotic bowel preparation vs no bowel preparation

Anastomotic leakage · Patients undergoing elective colorectal surgery

Summary of findings table ‐ Combined mechanical and oral antibiotic… showed no clear difference in anastomotic leakage compared with no bowel preparation (low certainty).

1 finding from 1 review

Summary of findings table ‐ Combined mechanical and oral antibiotic bowel preparation vs no bowel preparation

All‐cause mortality · Patients undergoing elective colorectal surgery

Summary of findings table ‐ Combined mechanical and oral antibiotic… showed no clear difference in mortality compared with no bowel preparation (low certainty).

1 finding from 1 review

Summary of findings table ‐ Combined mechanical and oral antibiotic bowel preparation vs no bowel preparation

Postoperative ileus · Patients undergoing elective colorectal surgery

Summary of findings table ‐ Combined mechanical and oral antibiotic… showed no clear difference in incidence of postoperative ileus compared with no bowel preparation (low certainty).

1 finding from 1 review