Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

75 questions · 76 findings · 4 reviews · Schizophrenia

No studies found 34 · 44.7%GRADE not reported 3 · 3.9%Very low 29 · 38.2%Low 7 · 9.2%Moderate 3 · 3.9%High 0 · 0%

Combinations of antipsychotic drugs vs single antipsychotic drugs

Clinical response: No clinically important response ‐ as defined by each of the studies · schizophrenia or related disorders

It is very uncertain whether combinations of antipsychotic drugs changes clinical response: No clinically important response ‐ as defined by… compared with single antipsychotic drugs (very low certainty).

1 finding from 1 review

Combinations of antipsychotic drugs vs single antipsychotic drugs

Adverse events: Serious event or requiring discontinuation · schizophrenia or related disorders

It is very uncertain whether combinations of antipsychotic drugs changes adverse events: Serious event or requiring discontinuation compared with single antipsychotic drugs (very low certainty).

1 finding from 1 review

PROMPT TYPE vs NO PROMPT

Did not attend appointment ‐ combination of telephone and text‐based prompts · people with severe mental disorders

It is very uncertain whether PROMPT TYPE changes did not attend appointment ‐ combination of telephone and text‐based… compared with NO PROMPT (very low certainty).

1 finding from 1 review

RISPERIDONE vs COMBINATION: a. RISPERIDONE + OXCARBAZEPINE

Adverse effects ‐ movement disorders · psychosis‐induced aggression or agitation (rapid tranquillisation)

It is very uncertain whether RISPERIDONE changes adverse effects: movement disorders, over 24 hours compared with COMBINATION: a. RISPERIDONE + OXCARBAZEPINE (very low certainty).

1 finding from 1 review

RISPERIDONE vs COMBINATION: b. RISPERIDONE + VALPROIC ACID

Adverse effects ‐ movement disorders · psychosis‐induced aggression or agitation (rapid tranquillisation)

It is very uncertain whether RISPERIDONE changes adverse effects: movement disorders, over 24 hours compared with COMBINATION: b. RISPERIDONE + VALPROIC ACID (very low certainty).

1 finding from 1 review