Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

10 questions · 11 findings · 3 reviews · Haematology · Headline outcomes only

No studies found 1 · 9.1%GRADE not reported 1 · 9.1%Very low 5 · 45.5%Low 4 · 36.4%Moderate 0 · 0%High 0 · 0%

MSCs vs placebo or control

Death during study period · patients with a haematological condition who receive a haematopoietic stem cell transplant as treatment for their condition.

MSCs showed no clear difference in all‐cause mortality (prophylactic trials) (over duration of trial) compared with control/placebo (low certainty).

2 findings from 1 review

MSCs vs placebo or control

Relapse of malignant disease (prophylactic trials) (>12‐month · patients with a haematological condition who receive a haematopoietic stem cell transplant as treatment for their condition.

MSCs showed no clear difference in relapse of malignant disease (prophylactic trials) (>12‐month compared with control/placebo (low certainty).

1 finding from 1 review

MSCs vs placebo or control

Incidence of acute GvHD (prophylactic trials) · patients with a haematological condition who receive a haematopoietic stem cell transplant as treatment for their condition.

MSCs showed no clear difference in incidence of acute GvHD (prophylactic trials) compared with control/placebo (low certainty).

1 finding from 1 review

MSCs vs placebo or control

Incidence of chronic GvHD (prophylactic trials) · patients with a haematological condition who receive a haematopoietic stem cell transplant as treatment for their condition.

MSCs may leads to lower incidence of chronic GvHD (prophylactic trials) compared with control/placebo (low certainty).

1 finding from 1 review

MSCs vs placebo or control

Acute GvHD complete response (therapeutic trials) · patients with a haematological condition who receive a haematopoietic stem cell transplant as treatment for their condition.

It is very uncertain whether MSCs changes acute GvHD complete response (therapeutic trials) compared with control/placebo (very low certainty).

1 finding from 1 review

MSCs vs placebo or control

Chronic GvHD complete response (therapeutic trials) · patients with a haematological condition who receive a haematopoietic stem cell transplant as treatment for their condition.

It is very uncertain whether MSCs changes chronic GvHD complete response (therapeutic trials) compared with control/placebo (very low certainty).

1 finding from 1 review