Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

92 questions · 93 findings · 12 reviews · Schizophrenia

No studies found 15 · 16.1%GRADE not reported 11 · 11.8%Very low 43 · 46.2%Low 12 · 12.9%Moderate 12 · 12.9%High 0 · 0%

CHLORPROMAZINE vs piperacetazine

Global state: clinically important change in global state · patients with schizophrenia

It is very uncertain whether chlorpromazine changes global state: clinically important change ‐ as defined by each of… compared with piperacetazine (very low certainty).

1 finding from 1 review

CHLORPROMAZINE vs piperacetazine

Adverse effects/events: incidence of adverse effects ‐ as defined by each of the studies · patients with schizophrenia

It is very uncertain whether chlorpromazine changes adverse effects/events: incidence of adverse effects ‐ as defined by… compared with piperacetazine (very low certainty).

1 finding from 1 review

CHLORPROMAZINE vs piperacetazine

Adverse effects. Specific: movement disorders ‐ parkinsonism · patients with schizophrenia

It is very uncertain whether chlorpromazine changes adverse effects/events: clinically important movement disorder… compared with piperacetazine (very low certainty).

1 finding from 1 review

CHLORPROMAZINE vs metiapine

Global State: clinically important improvement · patients with schizophrenia

It is very uncertain whether chlorpromazine changes global state: clinically important improvement Clinical Global… compared with metiapine (very low certainty).

2 findings from 1 review

CHLORPROMAZINE vs metiapine

Adverse effects. Specific: movement disorders ‐ parkinsonism · patients with schizophrenia

It is very uncertain whether chlorpromazine changes adverse effects. Specific: movement disorders ‐ parkinsonism compared with metiapine (very low certainty).

1 finding from 1 review

CHLORPROMAZINE vs Clotiapine

Adverse effects: incidence of serious adverse effects. Movement disorders ‐ dyskinesia ‐short‐term · patients with schizophrenia

It is very uncertain whether chlorpromazine changes adverse effects: incidence of serious adverse effects. Movement… compared with clotiapine (very low certainty).

1 finding from 1 review

CHLORPROMAZINE vs Clotiapine

Adverse effects: 1. Clinically significant extrapyramidal side effects (2‐10 weeks) vs. standard higher dose (> 7.5‐15 mg/day) · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

CHLORPROMAZINE vs Clotiapine

Leaving the study early · patients with schizophrenia

It is very uncertain whether chlorpromazine changes leaving the study early: for any reason compared with clotiapine (very low certainty).

1 finding from 1 review