Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

207 questions · 244 findings · 20 reviews · Headline outcomes only

No studies found 53 · 21.7%GRADE not reported 6 · 2.5%Very low 50 · 20.5%Low 39 · 16%Moderate 69 · 28.3%High 27 · 11.1%

Botulinum toxin type A vs botulinum toxin type B

Adverse events: sore throat/dry mouth № of participants: 212 (2 RCTs) · adults with cervical dystonia

Botulinum toxin type A probably leads to higher adverse events: sore throat/dry mouth № of participants: 212 (2 RCTs) compared with botulinum toxin type B (moderate certainty).

1 finding from 1 review

Botulinum toxin vs surgery

Improved or corrected strabismusa at 6 or 12 months · adults and children with strabismus

Botulinum toxin may leads to lower improved or corrected strabismusa at 6 or 12 months compared with surgery (low certainty).

1 finding from 1 review

Botulinum toxin vs surgery

Proportion of participants requiring additional surgery(ies) at 6 or 12 months · adults and children with strabismus

It is very uncertain whether botulinum toxin changes proportion of participants requiring additional surgery(ies) at 6 or… compared with surgery (very low certainty).

1 finding from 1 review

Botulinum toxin vs surgery

Proportion of participants who achieved binocular single vision at 6 or 12 months · adults and children with strabismus

Botulinum toxin showed no clear difference in proportion of participants who achieved binocular single vision at 6… compared with surgery (low certainty).

1 finding from 1 review