Cochrane · systematic review · CD012285
Botulinum toxin for motor and phonic tics in Tourette's syndrome
Pandey, S, Srivanitchapoom, P, Kirubakaran, R, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Movement DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
3
No studies
3
Included studies
NR
No studies 3 · 50%Ungraded 0 · 0%Very low 3 · 50%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Botulinum toxin compared to Placebo for motor and phonic tics in Tourette's syndrome
Population: Tourette's syndrome with motor and phonic tics
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Severity of motor tics (measured by videotape of tic count) Botulinum toxin vs Placebo | no estimate extracted | 1 study · 18 participants | Very low Downgraded: indirectness |
Severity of phonic tics Botulinum toxin vs Placebo | no estimate extracted | NR | No studies |
Premonitory Urge (treated tics) Botulinum toxin vs Placebo | no estimate extracted | 1 study · 18 participants | Very low Downgraded: indirectness |
Sensory tics Botulinum toxin vs Placebo | no estimate extracted | NR | No studies |
Adverse events Botulinum toxin vs Placebo | no estimate extracted | 1 study · 18 participants | Very low Downgraded: indirectness |
Development of immunoresistance against botulinum toxin Botulinum toxin vs Placebo | no estimate extracted | NR | No studies |