Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

217 questions · 259 findings · 23 reviews

No studies found 55 · 21.2%GRADE not reported 17 · 6.6%Very low 50 · 19.3%Low 40 · 15.4%Moderate 69 · 26.6%High 28 · 10.8%

Botulinum toxin type A vs botulinum toxin type B

Adverse events: sore throat/dry mouth № of participants: 212 (2 RCTs) · adults with cervical dystonia

Botulinum toxin type A probably leads to higher adverse events: sore throat/dry mouth № of participants: 212 (2 RCTs) compared with botulinum toxin type B (moderate certainty).

1 finding from 1 review

Botulinum toxin vs surgery

Improved or corrected strabismusa at 6 or 12 months · adults and children with strabismus

Botulinum toxin may leads to lower improved or corrected strabismusa at 6 or 12 months compared with surgery (low certainty).

1 finding from 1 review

Botulinum toxin vs surgery

Proportion of participants requiring additional surgery(ies) at 6 or 12 months · adults and children with strabismus

It is very uncertain whether botulinum toxin changes proportion of participants requiring additional surgery(ies) at 6 or… compared with surgery (very low certainty).

1 finding from 1 review

Botulinum toxin vs surgery

Proportion of participants who achieved binocular single vision at 6 or 12 months · adults and children with strabismus

Botulinum toxin showed no clear difference in proportion of participants who achieved binocular single vision at 6… compared with surgery (low certainty).

1 finding from 1 review