Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

31 questions · 31 findings · 6 reviews

No studies found 7 · 22.6%GRADE not reported 2 · 6.5%Very low 15 · 48.4%Low 6 · 19.4%Moderate 1 · 3.2%High 0 · 0%

Direct‐acting antivirals vs control

Proportion of participants with one or more serious adverse event at maximum · adults with chronic hepatitis C

It is very uncertain whether direct‐acting antivirals changes proportion of participants with one or more serious adverse event at… compared with control (very low certainty).

1 finding from 1 review

Direct‐acting antivirals vs control

Proportion of participants with no sustained virological response at maximum · adults with chronic hepatitis C

Direct‐acting antivirals may leads to lower proportion of participants with no sustained virological response at… compared with control (low certainty).

1 finding from 1 review

Direct‐acting antivirals withdrawn from the market vs control

Proportion of participants with one or more serious adverse event at maximum · adults with chronic hepatitis C

It is very uncertain whether direct‐acting antivirals withdrawn from the market changes proportion of participants with one or more serious adverse event at… compared with control (very low certainty).

1 finding from 1 review

Direct‐acting antivirals withdrawn from the market vs control

Proportion of participants with no sustained virological response at maximum · adults with chronic hepatitis C

Direct‐acting antivirals withdrawn from the market may leads to lower proportion of participants with no sustained virological response at… compared with control (low certainty).

1 finding from 1 review

Antivirals plus corticosteroids vs corticosteroids plus placebo or no treatment

Incomplete recovery at end of study № of participants: 766 (3 RCTs) · Bell's palsy

Antivirals plus corticosteroids showed no clear difference in incomplete recovery at end of study № of participants: 766 (3 RCTs) compared with corticosteroids plus placebo or no treatment (AS versus OS) (low certainty).

1 finding from 1 review

Antivirals plus corticosteroids vs corticosteroids plus placebo or no treatment

Motor synkinesis or crocodile tears № of participants: 469 (2 RCTs) · Bell's palsy

Antivirals plus corticosteroids probably leads to lower motor synkinesis or crocodile tears № of participants: 469 (2 RCTs) compared with corticosteroids plus placebo or no treatment (AS versus OS) (moderate certainty).

1 finding from 1 review

Antivirals plus corticosteroids vs corticosteroids plus placebo or no treatment

Adverse events № of participants: 656 (2 RCTs) · Bell's palsy

It is very uncertain whether antivirals plus corticosteroids changes adverse events № of participants: 656 (2 RCTs) compared with corticosteroids plus placebo or no treatment (AS versus OS) (very low certainty).

1 finding from 1 review