Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

62 questions · 65 findings · 17 reviews · Stroke

No studies found 15 · 23.1%GRADE not reported 5 · 7.7%Very low 15 · 23.1%Low 11 · 16.9%Moderate 11 · 16.9%High 8 · 12.3%

Summary of findings table ‐ Starting long‐term therapeutic dose oral anticoagulation vs avoiding anticoagulation

Intracranial haemorrhage · survivors of stroke due to intracerebral haemorrhage with atrial fibrillation

Summary of findings table ‐ Starting long‐term therapeutic dose oral… showed no clear difference in intracranial haemorrhage compared with avoiding anticoagulation (moderate certainty).

1 finding from 1 review

Thrombo‐aspiration alone vs stent‐retrieval thrombectomy alone

Intracranial hemorrhage on imaging at 24 hours · people with acute ischemic stroke

Thrombo‐aspiration alone showed no clear difference in intracranial hemorrhage on imaging at 24 hours compared with stent‐retrieval thrombectomy alone (high certainty).

1 finding from 1 review

Thrombo‐aspiration alone vs stent‐retrieval thrombectomy alone

Symptomatic intracranial haemorrhage at · people with acute ischemic stroke

Thrombo‐aspiration alone showed no clear difference in symptomatic intracranial hemorrhage at 24 hours compared with stent‐retrieval thrombectomy alone (high certainty).

1 finding from 1 review

Antiplatelet drug vs control

Symptomatic intracranial haemorrhage during treatment period · acute ischaemic stroke

It is very uncertain whether antiplatelet drug changes symptomatic intracranial haemorrhage during treatment period compared with control (very low certainty).

1 finding from 1 review

Antiplatelet drug vs control

Major extracranial haemorrhage during treatment period · acute ischaemic stroke

It is very uncertain whether antiplatelet drug changes major extracranial haemorrhage during treatment period compared with control (very low certainty).

1 finding from 1 review

General anaesthesia vs non‐general anaesthesia

Intracranial haemorrhage · acute ischaemic stroke endovascular treatment (long‐term)

The review found no eligible studies for this question.

2 findings from 1 review

Anticoagulant vs control

Symptomatic intracranial haemorrhage during treatment period · acute presumed ischaemic stroke

Summary of findings table ‐ Anticoagulant probably leads to higher symptomatic intracranial haemorrhage during treatment period compared with control (moderate certainty).

1 finding from 1 review

Anticoagulant vs control

Major extracranial haemorrhage during treatment period · acute presumed ischaemic stroke

Summary of findings table ‐ Anticoagulant probably leads to higher major extracranial haemorrhage during treatment period compared with control (moderate certainty).

1 finding from 1 review

Intravenous thrombolytic treatment vs standard‐of‐care therapy

Symptomatic intracranial haemorrhage at · people with stroke upon awakening

Intravenous thrombolytic treatment showed no clear difference in symptomatic intracranial haemorrhage at compared with standard medical care (high certainty).

1 finding from 1 review