Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,123 questions · 2,188 findings · 243 reviews

No studies found 493 · 22.5%GRADE not reported 160 · 7.3%Very low 600 · 27.4%Low 474 · 21.7%Moderate 364 · 16.6%High 97 · 4.4%

Intervention not reported

CRBSI (confirmed) Clinical and microbiological assessments · newborn infants who require a central venous catheter

The intervention leads to lower CRBSI (confirmed) Clinical and microbiological assessments (high certainty).

1 finding from 1 review

Intervention not reported

CRBSI (suspected) Clinical assessment · newborn infants who require a central venous catheter

The intervention showed no clear difference in CRBSI (suspected) Clinical assessment (moderate certainty).

1 finding from 1 review

Intervention not reported

Total CRBSI (confirmed and suspected) Clinical and microbiological assessments · newborn infants who require a central venous catheter

The intervention leads to lower total CRBSI (confirmed and suspected) Clinical and microbiological… (high certainty).

1 finding from 1 review

Intervention not reported

Mortality Clinical assessment · newborn infants who require a central venous catheter

It is very uncertain whether the intervention changes mortality Clinical assessment (very low certainty).

1 finding from 1 review

Intervention not reported

Number of infants with hypoglycaemia Blood sugar level: glucose meter or laboratory‐based plasma glucose level · newborn infants who require a central venous catheter

The intervention leads to lower number of infants with hypoglycaemia Blood sugar level: glucose… (high certainty).

1 finding from 1 review

Intervention not reported

Incidence of pulmonary tuberculosis in children with HIV infection ‐ isoniazid prophylaxis only · children with HIV infection aged 12 years and under

The intervention showed no clear difference in incidence of pulmonary tuberculosis in children with HIV infection ‐… (moderate certainty).

1 finding from 1 review

Intervention not reported

Incidence of Pneumocystis carinii pneumonia infection in children with cancer ‐ trimethoprim‐sulfamethoxazole prophylaxis only · children with cancers aged 12 years and under

The intervention probably leads to lower incidence of Pneumocystis carinii pneumonia infection in children… (moderate certainty).

1 finding from 1 review

Intervention not reported

Mortality in children with HIV infection ‐ co‐trimoxazole prophylaxis only · children with HIV infection aged 12 years and under

The intervention probably leads to lower mortality in children with HIV infection ‐ co‐trimoxazole… (moderate certainty).

1 finding from 1 review

Intervention not reported

Mortality in children with HIV infection ‐ isoniazid prophylaxis only · children with HIV infection aged 12 years and under

The intervention showed no clear difference in mortality in children with HIV infection ‐ isoniazid prophylaxis only (low certainty).

1 finding from 1 review

Intervention not reported

Incidence of adverse events ‐ co‐trimoxazole prophylaxis only · children with HIV infection aged 12 years and under

The intervention showed no clear difference in incidence of adverse events ‐ co‐trimoxazole prophylaxis only (moderate certainty).

1 finding from 1 review

Intervention not reported

Incidence of Pseudomonas infection in children with cystic fibrosis ‐ ciprofloxacin prophylaxis only · children with cystic fibrosis aged 12 years and under

The intervention showed no clear difference in incidence of Pseudomonas infection in children with cystic fibrosis… (moderate certainty).

1 finding from 1 review