Arrest or reversal of noncavitated and cavitated root carious lesions · Adults (including institutionalized/older adults) with noncavitated and cavitated carious lesions on root surfaces (permanent teeth)
38% SDF solution (applied annually) may not differ from 5% NaF varnish for arrest or reversal of root carious lesions (RR 0.64, 95% CI 0.04 to 9.66; very low certainty).
1 finding from 1 review
Arrest or reversal of noncavitated carious lesions on any coronal surface · Children and adults with noncavitated carious lesions on any coronal surface (primary and permanent teeth)
1.23% APF gel was probably more effective than 10% CPP-ACP paste for arrest or reversal of any-coronal carious lesions (RR 2.19, 95% CI 1.83 to 2.61; moderate certainty).
1 finding from 1 review
Intervention not reported
Dental caries prevalence · Children (<12 years) and adolescents (12-18 years) with type 1 diabetes
Caries prevalence was highest in South American studies at 84% (95% CI 0.67 to 0.94); certainty not graded.
1 finding from 1 review
Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth)
0.2% NaF mouthrinse + supervised toothbrushing may not differ from Sealant for arrest or reversal of occlusal carious lesions (RR 0.98, 95% CI 0.84 to 1.14; low certainty).
1 finding from 1 review
Intervention not reported
Dental caries prevalence · Children (<12 years) and adolescents (12-18 years) with type 1 diabetes
Caries prevalence in Asian studies was 67% (95% CI 0.43 to 0.85); certainty not graded.
1 finding from 1 review
total microbial load (log10 CFU) · humans with open primary dentine caries
In one study, hardness category differences exceeded color category differences; no meta-analysis was conducted.
1 finding from 1 review
Intervention not reported
Dental caries prevalence · Children (<12 years) and adolescents (12-18 years) with type 1 diabetes
Caries prevalence was lowest among those with good metabolic control at 47% (95% CI 0.30 to 0.64); certainty not graded.
1 finding from 1 review
DMFT/DMFS index (dental caries experience) · Children aged 0-12 years in the United Kingdom
In UK studies, OHPPs were associated with lower DMFT/S (OR 0.04, 95% CI 0.00 to 0.58; ungraded).
1 finding from 1 review
Intervention not reported
Clinical and radiographic success
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Intervention not reported
Dental caries prevalence · Children (<12 years) and adolescents (12-18 years) with type 1 diabetes
Caries prevalence in European studies was 57% (95% CI 0.41 to 0.72); certainty not graded.
1 finding from 1 review
Arrest of advanced cavitated carious lesions on any coronal surface · Preschool children with advanced cavitated carious lesions on any coronal surface (primary teeth)
38% SDF solution (applied biannually) was more effective than 38% SDF solution (applied annually) for arrest or reversal of cavitated coronal carious lesions (RR 1.21, 95% CI 1.12 to 1.3; high certainty).
4 findings from 1 review
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Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth)
Sealant was probably more effective than no treatment for arrest or reversal of occlusal carious lesions (RR 1.98, 95% CI 1.61 to 2.44; moderate certainty).
1 finding from 1 review
Lactobacillus count (pre- vs post-treatment) · Medically healthy individuals (adults and children, 6-60 years)
Placebo rinse did not significantly change Lactobacillus counts relative to baseline; not GRADE-rated.
1 finding from 1 review
Development of >=1 new carious lesion (caries incidence) · Caries-free children to young adults with premolars/molars requiring pit-and-fissure sealants
In the single study reporting it, caries incidence was 0% in both the laser-alone and acid-etching groups (ungraded, single study).
1 finding from 1 review
Karaman 2013 (Er,Cr:YSGG laser vs acid-etching): incidence of caries was 0% in both groups; not meta-analyzed.
1 study · 16 participants
GRADE not reported
Arrest or reversal of noncavitated and cavitated root carious lesions · Adults (including institutionalized/older adults) with noncavitated and cavitated carious lesions on root surfaces (permanent teeth)
1% chlorhexidine + 1% thymol varnish may not differ from 38% SDF + potassium iodide solution (applied annually) for arrest or reversal of root carious lesions (RR 0.71, 95% CI 0.11 to 4.45; very low certainty).
1 finding from 1 review
Lactobacillus count (pre- vs post-treatment) · Medically healthy individuals (adults and children, 6-60 years)
Salvadora persica rinse reduced Lactobacillus counts relative to baseline; not GRADE-rated.
1 finding from 1 review
Temporomandibular disorders (TMD), TMJ arthritis/involvement and orofacial pain · Children and adolescents with juvenile idiopathic arthritis (JIA)
TMD and TMJ arthritis/involvement (and orofacial pain) were consistently reported more frequently in children/adolescents with JIA than in healthy peers, though several studies had small samples; no pooled estimate (ungraded).
1 finding from 1 review
Arrest of advanced cavitated carious lesions on any coronal surface · Preschool children with advanced cavitated carious lesions on any coronal surface (primary teeth)
30% SDF solution (applied annually) probably did not differ from 30% SDF solution (once weekly for 3 weeks) for arrest or reversal of cavitated coronal carious lesions (RR 1.13, 95% CI 0.95 to 1.34; moderate certainty).
3 findings from 1 review
Intervention not reported
Restorative index, primary teeth
1 finding from 1 review
no estimate extracted
2 studies
GRADE not reported
Plaque · Medically healthy individuals (adults and children, 6-60 years)
When usual mechanical plaque control continued, Salvadora persica and chlorhexidine did not differ significantly for plaque; not GRADE-rated.
8 findings from 1 review
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