Gap finder
Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
2,280 questions in 114 reviews · Cystic Fibrosis and Genetic Disorders
current versionsNo studies 856 · 37.5%Ungraded 58 · 2.5%Very low 550 · 24.1%Low 502 · 22%Moderate 271 · 11.9%High 43 · 1.9%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Summary of findings ‐ nebulisers for delivering tobramycin: conventional systems vs VMT Quality of life · children and adults with cystic fibrosis Nebuliser systems for drug delivery in cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ nebulisers for delivering other aerosolised medications: VMT and AAD tidal breathing mode (TBM) vs VMT and AAD target inhalation mode (TIM) Time to next exacerbation · adults with cystic fibrosis Nebuliser systems for drug delivery in cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ nebulisers for delivering other aerosolised medications: VMT and AAD tidal breathing mode (TBM) vs VMT and AAD target inhalation mode (TIM) Participant satisfaction or preference · adults with cystic fibrosis Nebuliser systems for drug delivery in cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 15 participants | Very low |
Summary of findings ‐ nebulisers for delivering other aerosolised medications: conventional systems vs ultrasonic nebulisers Treatment time (min) · children and adults with cystic fibrosis Nebuliser systems for drug delivery in cystic fibrosis (2023) · Cochrane | no estimate extracted | 2 studies · 8 participants | Very low |
Summary of findings ‐ nebulisers for delivering other aerosolised medications: conventional systems vs ultrasonic nebulisers Quality of life · children and adults with cystic fibrosis Nebuliser systems for drug delivery in cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ nebulisers for delivering other aerosolised medications: conventional systems vs ultrasonic nebulisers Serum deposition Cmax · children and adults with cystic fibrosis Nebuliser systems for drug delivery in cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ nebulisers for delivering other aerosolised medications: conventional systems vs ultrasonic nebulisers Adverse events · children and adults with cystic fibrosis Nebuliser systems for drug delivery in cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 8 participants | Very low |
Summary of findings ‐ nebulisers for delivering other aerosolised medications: conventional systems vs ultrasonic nebulisers FEV1 (L) · children and adults with cystic fibrosis Nebuliser systems for drug delivery in cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 8 participants | Very low |
Summary of findings ‐ nebulisers for delivering other aerosolised medications: conventional systems vs ultrasonic nebulisers Time to next exacerbation · children and adults with cystic fibrosis Nebuliser systems for drug delivery in cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ nebulisers for delivering other aerosolised medications: conventional systems vs ultrasonic nebulisers Participant satisfaction or preference · children and adults with cystic fibrosis Nebuliser systems for drug delivery in cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 8 participants | Very low |
Summary of findings: ACBT vs CCPT Quality of life · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ACBT vs PEP mask therapy Adverse events · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ACBT vs PEP mask therapy FEV1: % predicted (change from baseline) · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ACBT vs PEP mask therapy FVC: % predicted (change from baseline) · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ACBT vs PEP mask therapy Sputum weight (change from baseline) · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ACBT vs PEP mask therapy Number of pulmonary exacerbations · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ACBT vs OD Quality of life (change from baseline) in SF‐36 score and CRQ score · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 30 participants | Very low |
Summary of findings: ACBT vs OD Personal preference · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | no estimate extracted | 6 participants | Ungraded |
Summary of findings: ACBT vs OD Adverse events · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ACBT vs OD FEV1: % predicted (change from baseline) · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | no estimate extracted | 6 participants | Ungraded |
Summary of findings: ACBT vs OD FVC: % predicted (change from baseline) · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | no estimate extracted | 6 participants | Ungraded |
Summary of findings: ACBT vs CCPT Personal preference · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ACBT vs OD Sputum weight (change from baseline) · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | no estimate extracted | 6 participants | Ungraded |
Summary of findings: ACBT vs OD Number of pulmonary exacerbations · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ACBT vs other breathing techniques Quality of life (change from baseline) · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 30 participants | Very low |
Summary of findings: ACBT vs other breathing techniques Personal preference · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | no estimate extracted | 6 participants | Ungraded |
Summary of findings: ACBT vs other breathing techniques Adverse events · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ACBT vs other breathing techniques FEV1: % predicted (change from baseline) · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | no estimate extracted | 6 participants | Ungraded |
Summary of findings: ACBT vs other breathing techniques FVC: % predicted (change from baseline) · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | no estimate extracted | 6 participants | Ungraded |
Summary of findings: ACBT vs other breathing techniques Sputum weight (change from baseline) · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | no estimate extracted | 6 participants | Ungraded |
Summary of findings: ACBT vs other breathing techniques Number of pulmonary exacerbations · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ACBT vs exercise Quality of life (change from baseline) CFQ‐R score · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 19 participants | Very low |
Summary of findings: ACBT vs CCPT Adverse events · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ACBT vs exercise Personal preference · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ACBT vs exercise Adverse events · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 19 participants | Very low |
Summary of findings: ACBT vs exercise FEV1: % predicted (change from baseline) · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 19 participants | Very low |
Summary of findings: ACBT vs exercise FVC: % predicted (change from baseline) · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 19 participants | Very low |
Summary of findings: ACBT vs exercise Sputum weight (change from baseline) · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ACBT vs exercise Number of pulmonary exacerbations · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 22 participants | Very low |
Summary of findings: ACBT vs CCPT FEV1: % predicted (change from baseline) · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 1 participants | Ungraded |
Summary of findings: ACBT vs CCPT FVC: % predicted (change from baseline) · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 1 participants | Ungraded |
Summary of findings: ACBT vs CCPT Sputum weight (change from baseline) · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: ACBT vs CCPT Number of pulmonary exacerbations · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | RR 1.64 [0.62, 4.34] | 1 study · 63 participants | Low |
Summary of findings: ACBT vs PEP mask therapy Quality of life (change from baseline) SF‐36 score and CRQ score · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 30 participants | Very low |
Summary of findings: ACBT vs PEP mask therapy Personal preference · people with cystic fibrosis Active cycle of breathing technique for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings – bisphosphonates vs placebo or no treatment BMD Z score (total hip/femoral neck) · adults with β‐thalassaemia and osteoporosis Treatment for osteoporosis in people with beta‐thalassaemia (2023) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR BMD Z score (wrist) Â · people with β‐thalassaemia and osteoporosis Treatment for osteoporosis in people with beta‐thalassaemia (2023) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Incidence of fractures · people with β‐thalassaemia and osteoporosis Treatment for osteoporosis in people with beta‐thalassaemia (2023) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Mobility · people with β‐thalassaemia and osteoporosis Treatment for osteoporosis in people with beta‐thalassaemia (2023) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Quality of life · people with β‐thalassaemia and osteoporosis Treatment for osteoporosis in people with beta‐thalassaemia (2023) · Cochrane | no estimate extracted | NR | No studies |