Findings

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Evidence found and GRADE certainty

178 questions · 227 findings · 11 reviews · Oral Health

No studies found 2 · 0.9%GRADE not reported 220 · 96.9%Very low 4 · 1.8%Low 0 · 0%Moderate 1 · 0.4%High 0 · 0%

AA+GG (homozygous) genotypes vs GA (heterozygous) genotype

Dental caries · Children (<18 years) with vs without dental caries

After removing Zhang 2006, the over-dominant model at BsmI(rs1544410) remained non-significant (OR 0.85); ungraded.

2 findings from 1 review

TT+GG (homozygous) genotypes vs TG (heterozygous) genotype

Dental caries · Children (<18 years) with vs without dental caries

TaqI/BglI(rs739837) over-dominant model: TT+GG vs TG was not significantly associated with dental caries (OR 0.89); ungraded.

1 finding from 1 review

CC genotype vs CT+TT genotypes

Dental caries · Children (<18 years) with vs without dental caries

Recessive model (CC vs CT+TT) at FokI(rs10735810) showed no significant association with caries (OR 1.23, 95% CI 0.97-1.55); ungraded.

1 finding from 1 review

CC+AA (homozygous) genotypes vs CA (heterozygous) genotype

Dental caries · Children (<18 years) with vs without dental caries

ApaI(rs7975232) over-dominant model: CC+AA vs CA was not significantly associated with dental caries (OR 0.91); ungraded.

1 finding from 1 review

AA+GG (homozygous) genotypes vs AG (heterozygous) genotype

Dental caries · Children (<18 years) with vs without dental caries

FokI(rs2228570) over-dominant model: AA+GG vs AG was not significantly associated with dental caries (OR 1.04); ungraded.

1 finding from 1 review

C allele vs A allele

Dental caries · Children (<18 years) with vs without dental caries

ApaI(rs7975232) allelic model: C vs A was not significantly associated with dental caries (OR 0.89); ungraded.

1 finding from 1 review

TT+CC (homozygous) genotypes vs CT (heterozygous) genotype

Dental caries · Children (<18 years) with vs without dental caries

Over-dominant model (CC+TT vs CT) at FokI(rs10735810) showed no significant association with caries (OR 0.83); ungraded.

1 finding from 1 review

A allele vs G allele

Dental caries · Children (<18 years) with vs without dental caries

FokI(rs2228570) allelic model: A vs G was not significantly associated with dental caries (OR 1.07); ungraded.

1 finding from 1 review

Higher circulating 25-hydroxyvitamin D (25(OH)D) concentration vs Lower circulating 25-hydroxyvitamin D (25(OH)D) concentration

Alzheimer’s disease · Participants in observational studies

The meta-analysis of observational studies reported a SMD (to OR) of 0.08 (95% CI 0.01 to 0.63) for higher versus lower circulating vitamin D concentration.

1 finding from 1 review

Higher circulating 25-hydroxyvitamin D (25(OH)D) concentration vs Lower circulating 25-hydroxyvitamin D (25(OH)D) concentration

Aggressive prostate cancer · Participants in observational studies

The meta-analysis of observational studies reported a OR of 0.88 (95% CI 0.68 to 1.15) for higher versus lower circulating vitamin D concentration.

1 finding from 1 review

Higher circulating 1,25-dihydroxyvitamin D (1,25(OH)2D) concentration vs Lower circulating 1,25-dihydroxyvitamin D (1,25(OH)2D) concentration

Prostate cancer · Participants in observational studies

The meta-analysis of observational studies reported a OR of 0.99 (95% CI 0.87 to 1.12) for higher versus lower circulating vitamin D concentration.

1 finding from 1 review

Higher circulating 25-hydroxyvitamin D (25(OH)D) concentration vs Lower circulating 25-hydroxyvitamin D (25(OH)D) concentration

Tuberculosis · Participants in observational studies

The meta-analysis of observational studies reported a SMD (to OR) of 0.29 (95% CI 0.19 to 0.46) for higher versus lower circulating vitamin D concentration.

1 finding from 1 review

Higher circulating 1,25-dihydroxyvitamin D (1,25(OH)2D) concentration vs Lower circulating 1,25-dihydroxyvitamin D (1,25(OH)2D) concentration

Breast cancer · Participants in observational studies

The meta-analysis of observational studies reported a OR of 0.99 (95% CI 0.68 to 1.47) for higher versus lower circulating vitamin D concentration.

1 finding from 1 review

Higher circulating 25-hydroxyvitamin D (25(OH)D) concentration vs Lower circulating 25-hydroxyvitamin D (25(OH)D) concentration

Fracture · Participants in observational studies

The meta-analysis of observational studies reported a SMD (to OR) of 0.31 (95% CI 0.23 to 0.42) for higher versus lower circulating vitamin D concentration.

1 finding from 1 review

Higher circulating 25-hydroxyvitamin D (25(OH)D) concentration vs Lower circulating 25-hydroxyvitamin D (25(OH)D) concentration

All cause mortality (in CKD patients) · Participants in observational studies

The meta-analysis of observational studies reported a RR of 0.88 (95% CI 0.81 to 0.93) for higher versus lower circulating vitamin D concentration.

1 finding from 1 review