Side effects / tolerability · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…
The review found no eligible studies for this question.
1 finding from 1 review
Treatment failure (annual failure rate) · Children with carious primary molars treated by pulpotomy (vital pulp therapy)
Preformed metal crowns had a low annual failure rate (2.5%) in primary molars after pulpotomy, but the evidence is of low quality (single high-risk-of-bias split-mouth RCT; not GRADE-rated).
2 findings from 1 review
Overall success (composite of clinical and radiographic success) · Human permanent teeth with irreversible pulpitis and open (immature) root apex due to carious pulp exposure
In open-apex teeth, pooled pulpotomy success was 95.8% (95% CI 81-99%); significantly higher than closed apex (z=2.33, p=0.02); ungraded.
1 finding from 1 review
total microbial load (log10 CFU) · humans with open primary dentine caries
In one study, hardness category differences exceeded color category differences; no meta-analysis was conducted.
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Immature (young) permanent teeth with open apex and vital pulp exposed to dental caries or trauma, in children aged 6-14 years
A single RCT found no difference in pulpotomy success between MTA and platelet-rich fibrin (both 100% through 24 months; not pooled; ungraded).
1 finding from 1 review
Single RCT (Keswani 2014, 62 teeth): 100% clinical and radiographic success in both MTA and PRF at 6, 12 and 24 months (MTA 29/29, 27/27, 26/26; PRF 30/30, 29/29, 27/27); no difference between groups; not pooled
1 study · 62 participants
GRADE not reported
Overall success (composite of clinical and radiographic success) · Immature (young) permanent teeth with open apex and vital pulp exposed to dental caries or trauma, in children aged 6-14 years
MTA and calcium hydroxide had similar clinical and radiographic pulpotomy success at 6 months (RR 1.00, 95% CI 0.94 to 1.06; 2 RCTs; ungraded).
2 findings from 1 review
Overall success (composite of clinical and radiographic success) · Immature (young) permanent teeth with open apex and vital pulp exposed to dental caries or trauma, in children aged 6-14 years
A single RCT found no difference in pulpotomy success between MTA and calcium-enriched mixture (both 100% at 6 and 12 months; not pooled; ungraded).
1 finding from 1 review
Single RCT (Nosrat 2012, 118 roots): 100% clinical and radiographic success in both MTA and CEM at 6 and 12 months (MTA 53/53 then 54/54 roots; CEM 55/55 then 57/57 roots); no statistical difference between groups at…
1 study · 118 participants
GRADE not reported
Overall success (composite of clinical and radiographic success) · Immature (young) permanent teeth with open apex and vital pulp exposed to dental caries or trauma, in children aged 6-14 years
A single RCT found higher pulpotomy success with triple antibiotic paste than abscess remedy (100% vs 80%; statistically significant, P<0.05; not pooled; ungraded).
1 finding from 1 review
Single RCT (Eppa 2018, 3-arm; 20 TAP and 20 AR teeth): TAP 100% (20/20) vs abscess remedy 80% (16/20) clinical and radiographic success; difference statistically significant at 3, 6, 9, 12, 18 and 24 months (P<0.05);…
1 study · 40 participants
GRADE not reported
Overall success (composite of clinical and radiographic success) · Immature (young) permanent teeth with open apex and vital pulp exposed to dental caries or trauma, in children aged 6-14 years
A single RCT found higher pulpotomy success with MTA than abscess remedy (100% vs 80%; statistically significant, P<0.05; not pooled; ungraded).
1 finding from 1 review
Single RCT (Eppa 2018, 3-arm; 20 MTA and 20 AR teeth): MTA 100% (20/20) vs abscess remedy 80% (16/20) clinical and radiographic success; the 4 abscess-remedy failures occurred at 3 months; difference statistically…
1 study · 40 participants
GRADE not reported
Overall success (composite of clinical and radiographic success) · Immature (young) permanent teeth with open apex and vital pulp exposed to dental caries or trauma, in children aged 6-14 years
A single 3-arm RCT found no difference in pulpotomy success between MTA and triple antibiotic paste (both 100%; not pooled; ungraded).
1 finding from 1 review
Single RCT (Eppa 2018, 3-arm; 20 MTA and 20 TAP teeth): 100% clinical and radiographic success in both MTA and TAP at all follow-ups (1-24 months); no difference between groups; not pooled
1 study · 40 participants
GRADE not reported
All occlusal carious lesions · Permanent molar surfaces in diagnostic accuracy studies (mostly in vitro; clinical)
Pooled specificity for visual detection of all occlusal lesions was 0.770 (95% CI 0.73 to 0.81).
2 findings from 1 review
Specificity 77.0 [73, 81]
51 studies
GRADE not reported
Specificity 75.3 [70, 80]
67 studies
GRADE not reported
Negative LR for detecting advanced proximal caries · Proximal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the conventional (all-studies) meta-analysis, the negative lr of radiographic detection for advanced proximal caries was 0.58 (95% CI 0.52 to 0.65) (ungraded).
3 findings from 1 review
Negative LR 0.58 [0.52, 0.65]
22 studies
GRADE not reported
Negative LR 0.58 [0.52, 0.65]
22 studies
GRADE not reported
Negative LR 0.58 [0.52, 0.65]
22 studies
GRADE not reported
Specificity for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the conventional (all-studies) meta-analysis, pooled specificity of visual detection for all (initial and advanced) occlusal caries was 75.3% (95% CI 70 to 80) (ungraded).
3 findings from 1 review
Specificity 75.3 [70, 80]
67 studies
GRADE not reported
Specificity 91.2 [88, 94]
12 studies
GRADE not reported
Specificity 77.0 [73, 81]
51 studies
GRADE not reported
PPV for detecting advanced occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the German private-practice setting, the positive predictive value of visual detection for advanced occlusal caries was 77.9% at an assumed prevalence of 22.0% (ungraded).
2 findings from 1 review
PPV 77.9
50 studies
GRADE not reported
PPV 30.6
55 studies
GRADE not reported
NPV for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the German private-practice setting, the negative predictive value of radiographic detection for all (initial and advanced) occlusal caries was 91.4% at an assumed prevalence of 11.0% (ungraded).
2 findings from 1 review
NPV 91.4
9 studies
GRADE not reported
NPV 85.0
11 studies
GRADE not reported
Advanced proximal carious lesions · Permanent molar surfaces in diagnostic accuracy studies (mostly in vitro; clinical)
Pooled sensitivity for radiographic detection of advanced proximal lesions was 0.444 (95% CI 0.38 to 0.51).
8 findings from 1 review
Sensitivity 44.4 [38, 51]
22 studies
GRADE not reported
Negative LR 0.58 [0.52, 0.65]
22 studies
GRADE not reported
Positive LR 9.82 [7.3, 13.3]
22 studies
GRADE not reported
Show 5 more findings
Specificity 95.5 [94, 97]
22 studies
GRADE not reported
Negative LR 0.58 [0.52, 0.65]
22 studies
GRADE not reported
Specificity 95.5 [94, 97]
22 studies
GRADE not reported
Sensitivity 44.4 [38, 51]
22 studies
GRADE not reported
Positive LR 9.82 [7.3, 13.3]
22 studies
GRADE not reported
Negative LR for detecting advanced occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the conventional (all-studies) meta-analysis, the negative lr of radiographic detection for advanced occlusal caries was 0.53 (95% CI 0.46 to 0.62) (ungraded).
3 findings from 1 review
Negative LR 0.53 [0.46, 0.62]
44 studies
GRADE not reported
Negative LR 0.51 [0.44, 0.6]
38 studies
GRADE not reported
Negative LR 0.54 [0.46, 0.63]
36 studies
GRADE not reported
Sensitivity for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Germany, pooled sensitivity of visual detection for all (initial and advanced) occlusal caries was 49.1% (95% CI 40 to 58) (ungraded).
3 findings from 1 review
Sensitivity 49.1 [40, 58]
12 studies
GRADE not reported
Sensitivity 85.5 [81, 89]
67 studies
GRADE not reported
Sensitivity 85.8 [82, 89]
51 studies
GRADE not reported
Negative LR for detecting all (initial and advanced) proximal caries · Proximal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Egypt, the negative lr of radiographic detection for all (initial and advanced) proximal caries was 0.65 (95% CI 0.57 to 0.74) (ungraded).
3 findings from 1 review
Negative LR 0.65 [0.57, 0.74]
31 studies
GRADE not reported
Negative LR 0.65 [0.57, 0.73]
34 studies
GRADE not reported
Negative LR 0.63 [0.56, 0.72]
38 studies
GRADE not reported
Positive LR for detecting advanced proximal caries · Proximal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Germany, the positive lr of radiographic detection for advanced proximal caries was 9.82 (95% CI 7.3 to 13.3) (ungraded).
3 findings from 1 review
Positive LR 9.82 [7.3, 13.3]
22 studies
GRADE not reported
Positive LR 9.82 [7.3, 13.3]
22 studies
GRADE not reported
Positive LR 9.82 [7.3, 13.3]
22 studies
GRADE not reported