Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

280 questions · 282 findings · 22 reviews · Musculoskeletal

No studies found 87 · 30.9%GRADE not reported 5 · 1.8%Very low 43 · 15.2%Low 94 · 33.3%Moderate 35 · 12.4%High 18 · 6.4%

Summary of findings table ‐ Adjunctive therapies in addition to land‐based exercise therapy vs placebo adjunctive therapies

Adverse events · Patients with osteoarthritis of the knee or hip

Summary of findings table ‐ Adjunctive therapies in addition to… showed no clear difference in adverse events compared with placebo adjunctive therapies (low certainty).

1 finding from 1 review

MTX combination vs MTX monotherapy

ACR 50 response of DMARDs naive patients Number of responders · patients with rheumatoid arthritis

MTX combination showed no clear difference in ACR 50 response of DMARDs naive patients Number of responders compared with MTX monotherapy (low certainty).

1 finding from 1 review

MTX combination vs MTX monotherapy

ACR 50 response of MTX inadequate responders number of responders · patients with rheumatoid arthritis

MTX combination probably leads to higher ACR 50 response of MTX inadequate responders number of responders compared with MTX monotherapy (moderate certainty).

1 finding from 1 review

MTX combination vs MTX monotherapy

ACR 50 response of non‐MTX DMARDs inadequate responders number of responders · patients with rheumatoid arthritis

MTX combination showed no clear difference in ACR 50 response of non‐MTX DMARDs inadequate responders number of… compared with MTX monotherapy (moderate certainty).

1 finding from 1 review

MTX combination vs MTX monotherapy

Withdrawal due to lack of efficacy or toxicity of DMARDs naive patients number of withdrawals · patients with rheumatoid arthritis

MTX combination showed no clear difference in withdrawal due to lack of efficacy or toxicity of DMARDs naive… compared with MTX monotherapy (moderate certainty).

1 finding from 1 review

MTX combination vs MTX monotherapy

Withdrawal due to lack of efficacy or toxicity of MTX inadequate responders number of withdrawals · patients with rheumatoid arthritis

MTX combination showed no clear difference in withdrawal due to lack of efficacy or toxicity of MTX inadequate… compared with MTX monotherapy (moderate certainty).

1 finding from 1 review

MTX combination vs MTX monotherapy

Withdrawal due to lack of efficacy or toxicity of non‐MTX DMARDs inadequate responders number of withdrawals · patients with rheumatoid arthritis

It is very uncertain whether MTX combination changes withdrawal due to lack of efficacy or toxicity of non‐MTX DMARDs… compared with MTX monotherapy (very low certainty).

1 finding from 1 review

MTX combination vs MTX monotherapy

Withdrawals due to adverse events · patients with rheumatoid arthritis

It is very uncertain whether MTX combination changes withdrawal due to adverse reactions (Pooled across regimens) number… compared with MTX monotherapy (very low certainty).

1 finding from 1 review