Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,679 questions · 1,720 findings · 335 reviews · Headline outcomes only

No studies found 192 · 11.2%GRADE not reported 75 · 4.4%Very low 526 · 30.6%Low 504 · 29.3%Moderate 305 · 17.7%High 118 · 6.9%

Planned early birth vs expectant management

Admission to neonatal intensive care unit · preterm prelabour rupture of membranes (PPROM)

Planned early birth probably leads to higher admission to neonatal intensive care compared with expectant management (moderate certainty).

1 finding from 1 review

Planned early birth vs expectant management

Length of maternal hospital stay (days) · preterm prelabour rupture of membranes (PPROM)

Planned early birth showed no clear difference in length of hospital stay (maternal) compared with expectant management (moderate certainty).

1 finding from 1 review

Planned early birth vs expectant management

Maternal infectious morbidity (chorioamnionitis and/or endometritis) · women with prelabour rupture of membranes at term (37 weeks' gestation or later)

Planned early birth may leads to lower maternal infectious morbidity (chorioamnionitis and/or endometritis) compared with expectant management (low certainty).

1 finding from 1 review

Planned early birth vs expectant management

Perinatal mortality · women with prelabour rupture of membranes at term (37 weeks' gestation or later)

Planned early birth showed no clear difference in perinatal mortality (stillbirth or neonatal mortality) compared with expectant management (moderate certainty).

1 finding from 1 review

Very early treatment vs expectant management

Severe intraventricular hemorrhage in infants who received neuroimaging · preterm infants

Very early treatment showed no clear difference in severe Intraventricular hemorrhage (grades III and IV) compared with expectant management (moderate certainty).

1 finding from 1 review

Very early treatment vs expectant management

Neurodevelopmental outcomes (moderate/severe cognitive delay at 18 to 24 months) · preterm infants

Very early treatment showed no clear difference in neurodevelopmental outcomes (moderate/severe cognitive delay at 18… compared with expectant management (low certainty).

1 finding from 1 review