Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,378 questions · 2,146 findings · 145 reviews

No studies found 167 · 7.8%GRADE not reported 1,674 · 78%Very low 148 · 6.9%Low 113 · 5.3%Moderate 40 · 1.9%High 4 · 0.2%

TT+GG (homozygous) genotypes vs TG (heterozygous) genotype

Dental caries · Children (<18 years) with vs without dental caries

TaqI/BglI(rs739837) over-dominant model: TT+GG vs TG was not significantly associated with dental caries (OR 0.89); ungraded.

1 finding from 1 review

CC genotype vs CT+TT genotypes

Dental caries · Children (<18 years) with vs without dental caries

Recessive model (CC vs CT+TT) at FokI(rs10735810) showed no significant association with caries (OR 1.23, 95% CI 0.97-1.55); ungraded.

1 finding from 1 review

CC+AA (homozygous) genotypes vs CA (heterozygous) genotype

Dental caries · Children (<18 years) with vs without dental caries

ApaI(rs7975232) over-dominant model: CC+AA vs CA was not significantly associated with dental caries (OR 0.91); ungraded.

1 finding from 1 review

AA+GG (homozygous) genotypes vs AG (heterozygous) genotype

Dental caries · Children (<18 years) with vs without dental caries

FokI(rs2228570) over-dominant model: AA+GG vs AG was not significantly associated with dental caries (OR 1.04); ungraded.

1 finding from 1 review

C allele vs A allele

Dental caries · Children (<18 years) with vs without dental caries

ApaI(rs7975232) allelic model: C vs A was not significantly associated with dental caries (OR 0.89); ungraded.

1 finding from 1 review

TT+CC (homozygous) genotypes vs CT (heterozygous) genotype

Dental caries · Children (<18 years) with vs without dental caries

Over-dominant model (CC+TT vs CT) at FokI(rs10735810) showed no significant association with caries (OR 0.83); ungraded.

1 finding from 1 review

A allele vs G allele

Dental caries · Children (<18 years) with vs without dental caries

FokI(rs2228570) allelic model: A vs G was not significantly associated with dental caries (OR 1.07); ungraded.

1 finding from 1 review

Dental caries vs Caries-free controls

Oral health-related quality of life · Indians

In adolescents (10-19 years), dental caries was associated with poorer OHRQoL (pooled OR 3.92; 5 studies); ungraded.

5 findings from 1 review
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Dental caries vs Caries-free controls

Oral health-related quality of life · Indian children aged 3-5 years

In children aged 3-5 years, early childhood caries was significantly associated with poorer OHRQoL (narrative; 3 studies); ungraded.

1 finding from 1 review

Country-level dental caries prevalence (Global Burden of Disease) vs Low vs high dental caries prevalence

Oral health-related quality of life · people aged 60 years and older living in the community

Lower country-level dental caries prevalence was associated with better OHRQoL (low-prevalence pooled mean 81.5, 95% CI 76.5 to 86.6, higher than high-prevalence countries); statistically significant (ungraded).

1 finding from 1 review

Dental caries (carious oral microbiome) vs Caries-free / healthy oral microbiome

Alpha diversity (Chao1, Observed, Shannon) · Adults providing oral (saliva/supragingival plaque) 16S rRNA microbiome samples

In adults, caries-vs-health alpha diversity differed for the Shannon index but not Chao1/Observed (ungraded).

1 finding from 1 review

Dental caries (carious oral microbiome) vs Caries-free / healthy oral microbiome

Alpha diversity (Shannon) · Children providing oral (saliva/supragingival plaque) 16S rRNA microbiome samples

In children, caries-vs-health Shannon alpha diversity differed significantly (ungraded).

1 finding from 1 review