Caries arrestment at the tooth level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
In one trial, SDF increased tooth-level caries arrestment versus 5% sodium fluoride varnish (OR 4.75; ungraded subgroup).
1 finding from 1 review
Caries arrestment at the surface level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
Pooling two highly heterogeneous trials, SDF showed no significant difference versus 5% sodium fluoride varnish in surface-level caries arrestment (OR 1.46; ungraded subgroup).
1 finding from 1 review
Early childhood caries experience (mean dmft) · Nigerian children with primary dentition (approximately 6 months to 5 years)
In primary dentition, high-frequency sugar consumption was associated with slightly higher, non-significant odds of caries (OR 1.13, 95% CI 0.23 to 5.44), with high heterogeneity (I2=83%; ungraded).
1 finding from 1 review
Caries arrestment at the tooth level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
SDF probably results in a slight increase in tooth-level caries arrestment versus other methods (moderate certainty).
1 finding from 1 review
Caries arrestment at the individual (patient) level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
Pooling two trials, SDF markedly increased individual-level caries arrestment versus placebo (OR 18.10; ungraded subgroup).
1 finding from 1 review
Caries arrestment at the surface level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
SDF probably makes little to no difference to surface-level caries arrestment versus other methods (moderate certainty).
1 finding from 1 review
Dental caries prevalence · Nigerian individuals, including children and adults, with primary or permanent dentition
High-frequency sugar consumption was associated with 18% higher but non-significant odds of dental caries in Nigeria (OR 1.18, 95% CI 0.87 to 1.59; I2=36%; ungraded).
1 finding from 1 review
Caries arrestment at the tooth level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
Pooling two trials, SDF and ART/glass ionomer cement showed no clear difference in tooth-level caries arrestment (OR 1.22, wide CI; ungraded subgroup).
1 finding from 1 review
Caries/restoration status in permanent molars · Children with dental caries in permanent (first) molars
SDF gave significantly better caries/restoration outcomes than ART over 9 months in children's permanent molars (p=0.004; ungraded).
1 finding from 1 review
Satyarup et al. (2022): 38% SDF vs ART; SDF group 5.6% carious teeth with partly lost restorations vs ART 16.7% carious with partly lost and 8.9% carious with completely lost restorations (p=0.004, favoring SDF).
1 study · 190 participants
GRADE not reported
New coronal caries in permanent molars (caries prevention) · Children with dental caries in permanent (first) molars
NaF gave a 48% prevented fraction (fissure site) vs water (p<0.002; ungraded).
3 findings from 1 review
Prevented Fraction 48
1 study · 501 participants
GRADE not reported
Prevented Fraction 47
1 study · 141 participants
GRADE not reported
Prevented Fraction 41
1 study · 501 participants
GRADE not reported
New coronal caries in permanent first molars (caries prevention) · Children with dental caries in permanent (first) molars
ART within a brushing programme significantly reduced caries vs control (p<0.01; ungraded).
2 findings from 1 review
Mean new caries increment (surfaces) 0.01
1 study · 1016 participants
GRADE not reported
Mean new caries increment (surfaces) 0.06
1 study · 1016 participants
GRADE not reported
New coronal caries in permanent first molars (caries prevention) · Children with dental caries in permanent (first) molars
One-time ammonium bifluoride gave a 56% prevented fraction, similar to SDF (57%) (single study; ungraded).
1 finding from 1 review
New coronal carious lesions or fillings on permanent (first) molars (caries prevention) · Children with dental caries in permanent (first) molars
One-time SDF within a brushing programme did not significantly reduce caries vs control (p>0.05; ungraded).
2 findings from 1 review
New coronal caries in permanent molars (caries prevention) · Children with dental caries in permanent (first) molars
Resin sealant gave a 65% prevented fraction (fissure site) vs water, the highest fissure-site value (p<0.002; ungraded).
2 findings from 1 review
New coronal carious lesions or fillings on permanent (first) molars (caries prevention) · Children with dental caries in permanent (first) molars
One-time 38% SDF gave a 57% prevented fraction for caries in children's permanent first molars (single study; ungraded).
1 finding from 1 review
Dental caries prevalence and severity · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in dental caries/severity between ART regimens (very low certainty).
1 finding from 1 review
Development of >=1 new carious lesion (caries incidence) · Children with caries-free or non-cavitated carious lesion primary molars, aged 3-7 years (paediatric department, dental hospital, France)
2 findings from 1 review
Development of >=1 new carious lesion (caries incidence) · Children with caries-free primary first molars (with or without caries on other teeth), aged 1-5 years (paediatric clinic/dental school,…
Glass ionomer-based sealant may leads to lower development of >=1 new carious lesion (caries incidence) compared with no sealant (low certainty).
2 findings from 1 review
Mean caries increment (mean number of new cavitated occlusal lesions) · Children with caries-free or non-cavitated carious lesion primary molars, aged 3-7 years (paediatric department, dental hospital, France)
1 finding from 1 review
Progression of non-cavitated enamel caries · Children with caries-free second primary molars, aged 4-8 years (dental clinic, Turkey and Spain)
The review found no eligible studies for this question.
1 finding from 1 review