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Evidence found and GRADE certainty

4,534 questions · 5,247 findings · 456 reviews

No studies found 1,142 · 21.8%GRADE not reported 1,503 · 28.6%Very low 1,040 · 19.8%Low 869 · 16.6%Moderate 554 · 10.6%High 139 · 2.6%

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Enamel caries in primary dentition (at 5 years) vs Caries-free primary dentition

Dentinal caries in permanent (newly erupted) teeth · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of age)

Enamel caries in the primary dentition is associated with about 1.6 times higher odds of dentinal caries in permanent teeth (single study; not GRADE-rated).

1 finding from 1 review

Dentinal caries in primary dentition (at 5 years) vs Caries-free primary dentition

Dentinal caries in permanent (newly erupted) teeth · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of age)

Dentinal caries in the primary dentition is associated with about 3.2 times higher odds of dentinal caries in permanent teeth (single study; not GRADE-rated).

1 finding from 1 review

Oral alkylating agents ± steroids vs steroids or placebo or both, or no treatment

Adverse events ‐ infection at 3 years · primary membranous nephropathy in adults with nephrotic syndrome

It is very uncertain whether oral alkylating agents ± steroids changes adverse events ‐ infection at 3 years compared with placebo/no treatment/steroids (very low certainty).

1 finding from 1 review

CBT plus hypnosis (combined package) vs usual care

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People aged 12 years and over with painful TMD lasting 3 months or longer

CBT plus hypnosis (combined package) led to lower pain intensity compared with usual care; GRADE not reported.

1 finding from 1 review

Toothpaste with a plaque-disclosing agent vs Conventional toothpaste

Gingivitis · Children aged 7 to 13 years with Down syndrome (mild to moderate ID); setting residential
1 finding from 1 review
  • Oral hygiene interventions for people with intellectual disabilities 2019 · Cochrane All outcomes
    Short term (<6 weeks)
    Toothpaste with a plaque-disclosing agent vs conventional toothpaste, children with Down syndrome. Ainamo & Bay Gingival Bleeding Index, mean 10 days; percent mean difference 18 (intervention) vs 8 (control), P<0.001…
    1 study · 40 participants
    Very low

Toothpaste with a plaque-disclosing agent vs Conventional toothpaste

Plaque · Children aged 7 to 13 years with Down syndrome (mild to moderate ID); setting residential
1 finding from 1 review
  • Oral hygiene interventions for people with intellectual disabilities 2019 · Cochrane All outcomes
    Short term (<6 weeks)
    Simplified Green & Vermillion Oral Hygiene Index (plaque), mean 10 days; percent mean difference 65 (intervention) vs 15 (control), P<0.0001 favouring the disclosing-agent toothpaste; 40 participants (SoF states 80,…
    1 study · 40 participants
    Very low

Psychosocial risk management ('Resettle' programme) vs usual care

Death during study period · adults with antisocial personality disorder

It is very uncertain whether psychosocial risk management ('Resettle' programme) changes adverse events: death during the study period Timing of assessment:… compared with treatment‐as‐usual (very low certainty).

1 finding from 1 review

Growth stunting (linear growth retardation, low height-for-age) vs Children without growth stunting (normal height-for-age)

Early childhood caries (ECC) · Children aged ≤6 years (early childhood)

One Nigerian cross-sectional study reported a significant adjusted association between nutritional (stunting) status and ECC (APR 0.14, 95% CI 0.03-0.69); ungraded.

4 findings from 1 review
Show 1 more finding

Tetanus diphtheria toxoid immunisation of women of reproductive age vs cholera toxoid

Neonatal death (death within the first 28 days of life) · women of reproductive age ≥ 15 years.

Tetanus diphtheria toxoid immunisation of women of reproductive age may leads to lower neonatal mortality in the first 28 days of life compared with cholera toxoid (low certainty).

1 finding from 1 review

Tetanus diphtheria toxoid immunisation of women of reproductive age vs cholera toxoid

Neonatal mortality between day 4‐14 of life · women of reproductive age ≥ 15 years.

Tetanus diphtheria toxoid immunisation of women of reproductive age may leads to lower neonatal mortality between day 4‐14 of life compared with cholera toxoid (low certainty).

1 finding from 1 review

Artificial bone graft: InFuse (collagen matrix) impregnated with rhBMP-2 vs Traditional iliac crest cancellous bone graft

Clinical assessment: alveolar ridge healing (0 to 3 grading scale) · Skeletally mature patients with unilateral cleft lip and palate and an alveolar cleft defect (>5 years; mean age 16.1 years)

Artificial bone graft: InFuse (collagen matrix) impregnated with… led to higher clinical assessment: alveolar ridge healing (0 to 3 grading scale) compared with traditional iliac crest cancellous bone graft; GRADE not reported.

1 finding from 1 review

Artificial bone graft: InFuse (collagen matrix) impregnated with rhBMP-2 vs Traditional iliac crest cancellous bone graft

Radiographic assessment: periapical film (0 to 3 grading scale) · Skeletally mature patients with unilateral cleft lip and palate and an alveolar cleft defect (>5 years; mean age 16.1 years)

Artificial bone graft: InFuse (collagen matrix) impregnated with… led to higher radiographic assessment: periapical film (0 to 3 grading scale) compared with traditional iliac crest cancellous bone graft; GRADE not reported.

1 finding from 1 review

Artificial bone graft: InFuse (collagen matrix) impregnated with rhBMP-2 vs Traditional iliac crest cancellous bone graft

Length of hospital stay · Skeletally mature patients with unilateral cleft lip and palate and an alveolar cleft defect (>5 years; mean age 16.1 years)

Artificial bone graft: InFuse (collagen matrix) impregnated with… led to lower length of hospital stay (days) compared with traditional iliac crest cancellous bone graft; GRADE not reported.

1 finding from 1 review